Sfrp1 - secreted frizzled-related protein 1 Gene

Mus musculus

Also known as sFRP-1; 2210415K03Rik

Gene ID: 20377 | Gene type: protein coding

About Sfrp1

Chromosome 8: 23,901,518-23,939,648 forward strand.GRCm39:CM001001.3

This gene has 1 transcript (splice variant), 223 orthologues, 15 paralogues and is associated with 15 phenotypes. Ubiquitous expression in kidney adult (RPKM 23.7), CNS E11.5 (RPKM 22.8) and 26 other tissues.

Summary

Predicted to enable several functions, including Wnt-protein binding activity; Frizzled binding activity; and heparin binding activity. Involved in several processes, including cellular response to X-ray; cellular response to estrogen stimulus; and negative regulation of B cell differentiation. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human SFRP1 (secreted Frizzled related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Sfrp1 Products(1)

mRNA	Protein	Name
NM_013834.3	NP_038862.2	secreted frizzled-related protein 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19188438	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	19850029	MGI
acts upstream of or within Wnt signaling pathway involved in somitogenesis	IGI IGI: Inferred from genetic interaction	18257070	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IDA IDA: Inferred from direct assay	18371946	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	16467359	MGI
acts upstream of or within bone trabecula formation	IMP IMP: Inferred from mutant phenotype	14976225	MGI
acts upstream of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18257070	MGI
involved in cellular response to X-ray	IDA IDA: Inferred from direct assay	19778523	MGI
involved in cellular response to estrogen stimulus	IDA IDA: Inferred from direct assay	18941195	MGI
acts upstream of or within convergent extension involved in somitogenesis	IGI IGI: Inferred from genetic interaction	18257070	MGI
acts upstream of or within development of primary male sexual characteristics	IGI IGI: Inferred from genetic interaction	19100252	MGI
acts upstream of or within digestive tract morphogenesis	IGI IGI: Inferred from genetic interaction	19300477	MGI
involved in dopaminergic neuron differentiation	IDA IDA: Inferred from direct assay	22535492	MGI
acts upstream of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	14976225	MGI
acts upstream of or within female gonad development	IGI IGI: Inferred from genetic interaction	19100252	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	19664990	MGI
acts upstream of or within male gonad development	IGI IGI: Inferred from genetic interaction	19100252	MGI
involved in negative regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	18941195	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	19850029	MGI
acts upstream of or within negative regulation of JUN kinase activity	IGI IGI: Inferred from genetic interaction	19300477	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	19300477	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	16149051	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	17462603	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19850029	MGI
acts upstream of or within negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	19254787	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	14976225	MGI
acts upstream of or within negative regulation of osteoblast proliferation	IMP IMP: Inferred from mutant phenotype	14976225	MGI
acts upstream of or within negative regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	14976225	MGI
acts upstream of or within neural crest cell fate commitment	IMP IMP: Inferred from mutant phenotype	20130188	MGI
acts upstream of or within neural tube closure	IGI IGI: Inferred from genetic interaction	19850029	MGI
acts upstream of or within neural tube development	IGI IGI: Inferred from genetic interaction	19850029	MGI
acts upstream of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	14976225	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	14976225	MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	IMP IMP: Inferred from mutant phenotype	18371946	MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	18371946	MGI
acts upstream of or within regulation of establishment of planar polarity	IGI IGI: Inferred from genetic interaction	19300477	MGI
involved in regulation of midbrain dopaminergic neuron differentiation	IGI IGI: Inferred from genetic interaction	22290867	MGI
involved in regulation of neuron projection development	IDA IDA: Inferred from direct assay	22290867	MGI
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	19778523	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19664990	MGI
involved in somitogenesis	IEP IEP: Inferred from expression pattern	10654605	MGI
acts upstream of or within somitogenesis	IGI IGI: Inferred from genetic interaction	16467359	MGI
involved in stromal-epithelial cell signaling involved in prostate gland development	IEP IEP: Inferred from expression pattern	16288033	MGI
involved in ureteric bud development	IEP IEP: Inferred from expression pattern	16545622	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sfrp1 Protein Structure

CRD_SFRP1

NTR_Sfrp1_like

0
100
200
314 a.a.

Protein Preferred Names

Protein Names

secreted frizzled-related protein 1

secreted frizzled-related sequence protein 1

Recombinant Sfrp1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73413	SFRP1 Protein, Mouse (CHO, His)	AAC53145.1 (S32-K314)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10858	WAY 316606	Inhibitor	99.24%	Unkown
HY-10858A	WAY 316606 hydrochloride	Inhibitor	/	Unkown
HY-RS12772	SFRP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12773	Sfrp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12774	Sfrp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sfrp1	NCBI	NCBI:6422

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