2. Gene
  3. SFRP1 - secreted frizzled related protein 1 Gene

SFRP1 - secreted frizzled related protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FRP; FRP1; FrzA; FRP-1; SARP2

Gene ID: 6422 | Gene type: protein coding

About SFRP1

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:41,261,962-41,309,473 (from NCBI)

This gene has 2 transcripts (splice variants), 223 orthologues and 15 paralogues. Broad expression in endometrium (RPKM 97.0), fat (RPKM 58.4) and 17 other tissues.

Summary

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with Cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]

SFRP1 Products(1)

mRNA Protein Name
NM_003012.5 NP_003003.3 secreted frizzled-related protein 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables Wnt-protein binding IDA
IDA: Inferred from direct assay
17462603 GOA
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
10347172 GOA
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
14581477 GOA
enables frizzled binding IPI
IPI: Inferred from physical interaction
1927703 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
9192640 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
10347172 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10347172 GOA
Biological Process GO Annotation Evidence Reference Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18787224 GOA
involved in cellular response to BMP stimulus IEP
IEP: Inferred from expression pattern
16149051 GOA
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
11932307 GOA
involved in cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
18941195 GOA
involved in cellular response to fibroblast growth factor stimulus IDA
IDA: Inferred from direct assay
17500071 GOA
involved in cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
17500071 GOA
involved in cellular response to heparin IDA
IDA: Inferred from direct assay
17500071 GOA
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
11932307 GOA
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
16149051 GOA
involved in cellular response to prostaglandin E stimulus IEP
IEP: Inferred from expression pattern
16149051 GOA
involved in cellular response to starvation IEP
IEP: Inferred from expression pattern
9724099 GOA
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
16149051 GOA
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
9391078 GOA
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
16149051 GOA
involved in dorsal/ventral axis specification IDA
IDA: Inferred from direct assay
9192640 GOA
involved in hematopoietic progenitor cell differentiation IDA
IDA: Inferred from direct assay
19778523 GOA
involved in hematopoietic stem cell differentiation IDA
IDA: Inferred from direct assay
19778523 GOA
involved in negative regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
18941195 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10660608 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16532032 GOA
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
10660608 GOA
involved in negative regulation of Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
9192640 GOA
involved in negative regulation of androgen receptor signaling pathway IDA
IDA: Inferred from direct assay
19277043 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11932307 GOA
involved in negative regulation of bone remodeling IMP
IMP: Inferred from mutant phenotype
19072540 GOA
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
9391078 GOA
involved in negative regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
17462603 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
9724099 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
19569235 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
10980594 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10347172 GOA
involved in negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
19095296 GOA
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
19095296 GOA
involved in negative regulation of fibroblast apoptotic process IDA
IDA: Inferred from direct assay
14581477 GOA
involved in negative regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
19734317 GOA
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
10980594 GOA
involved in negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
17994217 GOA
involved in negative regulation of ossification IDA
IDA: Inferred from direct assay
15677765 GOA
involved in negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
19254787 GOA
involved in negative regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
19072540 GOA
involved in negative regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
10980594 GOA
involved in osteoblast differentiation IEP
IEP: Inferred from expression pattern
16149051 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10660608 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19723665 GOA
involved in positive regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
10660608 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
9391078 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
9724099 GOA
involved in positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18941195 GOA
involved in positive regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
24080158 GOA
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
10980594 GOA
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
10980594 GOA
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
16288033 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: Inferred from direct assay
9391078 GOA
acts upstream of or within positive regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
12055200 GOA
involved in positive regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
15886250 GOA
involved in positive regulation of fibroblast apoptotic process IDA
IDA: Inferred from direct assay
14581477 GOA
involved in positive regulation of non-canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19569235 GOA
involved in positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
17035233 GOA
acts upstream of or within positive effect positive regulation of type B pancreatic cell proliferation IDA
IDA: Inferred from direct assay
17994217 GOA
involved in regulation of cell cycle process IMP
IMP: Inferred from mutant phenotype
9724099 GOA
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
20208569 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
9192640 GOA
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
9192640 GOA
located in cytosol IDA
IDA: Inferred from direct assay
14581477 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
9192640 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFRP1 Protein Structure

Fz

Fz: Fz domain (58 - 164)

NTR

NTR: UNC-6/NTR/C345C module (200 - 299)

  • 0
  • 100
  • 200
  • 314 a.a.
Protein Preferred Names Protein Names

secreted frizzled-related protein 1

SARP-2

frizzled-related protein

sFRP-1

secreted apoptosis-related protein 2

SFRP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SFRP1 Q8N474 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
SFRP1 Q8N474 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
SFRP1 Q8N474 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
SFRP1 Q8N474 FZD6 Homo sapiens O60353
Anti Tag CoIP
10347172
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SFRP1 Proteins

Cat. No. Product Name Accession Purity
HY-P74554 SFRP1 Protein, Human (HEK293, His) Q8N474 (S32-K314) ≥95%

Related Diseases

Diseases Alias
Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy

Fevr

Criswick-Schepens Syndrome

Exudative Vitreoretinopathy, Familial

Vitreoretinopathy, Exudative )

Exudative Vitreoretinopathy 1
Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Acute Closed-Angle Glaucoma

Acute Angle-Closure Glaucoma
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis
Sclerosteosis

Cortical Hyperostosis With Syndactyly

Sost

Cortical Hyperostosis-Syndactyly Syndrome
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea
Chronic Closed-Angle Glaucoma

Anatomical Narrow Angle Glaucoma

Chronic Angle-Closure Glaucoma

Chronic Narrow Angle Glaucoma

Secondary Angle-Closure Glaucoma - Synechial
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Myeloma, Multiple

Multiple Myeloma

Kahler Disease

Myelomatosis

Plasma Cell Myeloma

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler'S Disease

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10858 WAY 316606 Inhibitor 99.24% Unkown
HY-10858A WAY 316606 hydrochloride Inhibitor / Unkown
HY-RS12772 SFRP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12773 Sfrp1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12774 Sfrp1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SFRP1 VGNC VGNC:34520
Felis catus SFRP1 VGNC VGNC:80004
Mus musculus SFRP1 MGD MGI:892014
Rattus norvegicus SFRP1 RGD RGD:621074
Canis familiaris SFRP1 VGNC VGNC:46080
Macaca mulatta SFRP1 VGNC VGNC:77185
Others SFRP1 NCBI