EPHA5 - EPH receptor A5 Gene

Homo sapiens

Also known as EK7; CEK7; EHK1; HEK7; EHK-1; TYRO4

Gene ID: 2044 | Gene type: protein coding

About EPHA5

Cytogenetic location: 4q13.1-q13.2 Genomic coordinates (GRCh38): 4:65,319,567-65,670,489 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 53 paralogues. Biased expression in brain (RPKM 4.9), ovary (RPKM 1.0) and 6 other tissues.

Summary

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]

EPHA5 Products(6)

mRNA	Protein	Name
NM_001281765.3	NP_001268694.1	ephrin type-A receptor 5 isoform c
NM_001281766.3	NP_001268695.1	ephrin type-A receptor 5 isoform d
NM_001281767.3	NP_001268696.1	ephrin type-A receptor 5 isoform e
NM_001318761.2	NP_001305690.1	ephrin type-A receptor 5 isoform f
NM_004439.8	NP_004430.4	ephrin type-A receptor 5 isoform a
NM_182472.5	NP_872272.2	ephrin type-A receptor 5 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	35384245	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in neuron development	IEP IEP: Inferred from expression pattern	10375373	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	9191074	GOA
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	10064801	GOA
located in neuronal cell body	IDA IDA: Inferred from direct assay	10375373	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10375373	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10375373	GOA
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	10375373	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHA5 Protein Structure

Ephrin_lbd

fn3

EphA2_TM

Pkinase_Tyr

SAM_1

0
200
400
600
800
1037 a.a.

Protein Preferred Names

Protein Names

ephrin type-A receptor 5

EPH homology kinase 1

EPHA5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EPHA5	P54756	EPHA2	Homo sapiens	P29317	Anti Tag CoIP	35384245
Intra	EPHA5	P54756	EPHA2	Homo sapiens	P29317	BioID	35384245
Intra	EPHA5	P54756	EPHA2	Homo sapiens	P29317	Affinity Chrom	35384245
Intra	EPHA5	P54756	EPHB4	Homo sapiens	P54760	Anti Tag CoIP	35384245
Intra	EPHA5	P54756	EPHB4	Homo sapiens	P54760	Affinity Chrom	35384245

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHA5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77930	EPHA5 Protein, Human (HEK293, His)	P54756-1 (A26-P573)	≥95%

Related Diseases

Diseases

Alias

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Leber Congenital Amaurosis 17

LCA17

Leber Congenital Amaurosis, Type 17

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04429	EPHA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-146375	UniPR505	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EPHA5	VGNC	VGNC:40408
Bos taurus	EPHA5	VGNC	VGNC:28535
Felis catus	EPHA5	VGNC	VGNC:78486
Mus musculus	EPHA5	MGD	MGI:99654
Macaca mulatta	EPHA5	VGNC	VGNC:72238
Rattus norvegicus	EPHA5	RGD	RGD:620831
Macaca fascicularis	EPHA5	NCBI	NCBI:102138762
Others	EPHA5	NCBI

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