Slc16a1 - solute carrier family 16 (monocarboxylic acid transporters), member 1 Gene

Mus musculus

Also known as Mct1

Gene ID: 20501 | Gene type: protein coding

About Slc16a1

Chromosome 3: 104,545,984-104,565,778 forward strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 339 orthologues and 13 paralogues. Ubiquitous expression in colon adult (RPKM 55.3), placenta adult (RPKM 47.) and 27 other tissues.

Summary

Enables lactate transmembrane transporter activity. Involved in several processes, including behavioral response to nutrient; plasma membrane lactate transport; and regulation of Insulin secretion. Located in plasma membrane and synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 7. Orthologous to human SLC16A1 (solute carrier family 16 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc16a1 Products(1)

mRNA	Protein	Name
NM_009196.4	NP_033222.1	monocarboxylate transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lactate transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	29026134	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21792931	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to nutrient	IMP IMP: Inferred from mutant phenotype	24367518	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	22522610	MGI
involved in lipid metabolic process	IMP IMP: Inferred from mutant phenotype	24367518	MGI
involved in plasma membrane lactate transport	IMP IMP: Inferred from mutant phenotype	29026134	MGI
involved in pyruvate catabolic process	IMP IMP: Inferred from mutant phenotype	29026134	MGI
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	22522610	MGI
involved in response to food	IMP IMP: Inferred from mutant phenotype	24367518	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	15037112	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21792931	MGI
is active in synapse	EXP EXP: Inferred from Experiment	15572359	MGI
is active in synapse	IDA IDA: Inferred from direct assay	15572359	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc16a1 Protein Structure

2A0113

0
100
200
300
400
493 a.a.

Protein Preferred Names

Protein Names

monocarboxylate transporter 1

solute carrier family 16 member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13016	SLC16A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13017	Slc16a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13018	Slc16a1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc16a1	NCBI	NCBI:6566

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