Sort1 - sortilin 1 Gene

Mus musculus

Also known as Ntr3; Ntsr3; 2900053A11Rik

Gene ID: 20661 | Gene type: protein coding

About Sort1

Summary

Predicted to enable several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and Neurotensin Receptor activity, non-G protein-coupled. Involved in several processes, including glucose import; myotube differentiation; and response to Insulin. Acts upstream of or within endocytosis; negative regulation of fat cell differentiation; and protein targeting to lysosome. Located in cytoplasmic vesicle membrane; plasma membrane; and trans-Golgi network transport vesicle. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; eye; and genitourinary system. Orthologous to human SORT1 (sortilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Sort1 Products(2)

mRNA	Protein	Name
NM_001271599.1	NP_001258528.1	sortilin isoform 1 precursor
NM_019972.3	NP_064356.2	sortilin isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18480253	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-glucose import	IMP IMP: Inferred from mutant phenotype	15992544	MGI
acts upstream of or within endocytosis	IMP IMP: Inferred from mutant phenotype	24163244	MGI
involved in maintenance of synapse structure	IDA IDA: Inferred from direct assay	29398357	MGI
involved in maintenance of synapse structure	IMP IMP: Inferred from mutant phenotype	29398357	MGI
involved in myotube differentiation	IMP IMP: Inferred from mutant phenotype	18258592	MGI
acts upstream of or within negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	24928897	MGI
acts upstream of or within protein targeting to lysosome	IMP IMP: Inferred from mutant phenotype	19732768	MGI
involved in response to insulin	IMP IMP: Inferred from mutant phenotype	15992544	MGI
involved in vesicle organization	IMP IMP: Inferred from mutant phenotype	15992544	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cerebellar climbing fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	29398357	MGI
is active in cerebellar climbing fiber to Purkinje cell synapse	IMP IMP: Inferred from mutant phenotype	29398357	MGI
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	12490950	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15992544	MGI
located in trans-Golgi network transport vesicle	IDA IDA: Inferred from direct assay	15078902	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sortilin

mNTR3

neurotensin receptor 3

Sort1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sort1	Q6PHU5	Nradd	Mus musculus	Q8CJ26	IF	19407813
Intra	Sort1	Q6PHU5	Kcnk2	Mus musculus	P97438	Anti Bait CoIP	20405001
Intra	Sort1	Q6PHU5	Vps35	Mus musculus	Q9EQH3	Anti Bait CoIP	21040701

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153686	BVFP	Inhibitor	98.12%	Unkown
HY-RS13575	SORT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W747072	3-Sulfo-taurocholic Acid Disodium Salt		≥99.0%	Unkown
HY-132975	PrDiAzK	Inhibitor	/	Unkown
HY-153687	SORT-PGRN interaction inhibitor 2	Inhibitor	/	Unkown
HY-159868	SORT1-IN-1	Inhibitor	/	Unkown
HY-159875	SORT1-IN-2	Inhibitor	/	Unkown
HY-159876	SORT1-IN-3	Inhibitor	/	Unkown
HY-159877	SORT1-IN-4	Inhibitor	/	Unkown
HY-159878	SORT1-IN-5	Inhibitor	/	Unkown
HY-D1581	BODIPY 505/515-8-C3-COOH		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sort1	NCBI	NCBI:6272

Name
Email *

	Sorry, but the email address you supplied was invalid.