2. GPCR/G Protein Neuronal Signaling
  3. Neurotensin Receptor
  4. BVFP

BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis.

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BVFP Chemical Structure

BVFP Chemical Structure

CAS No. : 357158-20-4

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Based on 1 publication(s) in Google Scholar

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Description

BVFP binds to the PGRN588–593 peptide with a Kd of 20 μM. BVFP can disrupt PGRN-SORT1 binding. BVFP also inhibits SORT1-mediated rPGRN endocytosis[1].

Molecular Weight

345.11

Formula

C13H8BrF3N2O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N=C(C=C(C(F)(F)F)N1)/C=C/C2=CC(Br)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (144.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8976 mL 14.4881 mL 28.9763 mL
5 mM 0.5795 mL 2.8976 mL 5.7953 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8976 mL 14.4881 mL 28.9763 mL 72.4407 mL
5 mM 0.5795 mL 2.8976 mL 5.7953 mL 14.4881 mL
10 mM 0.2898 mL 1.4488 mL 2.8976 mL 7.2441 mL
15 mM 0.1932 mL 0.9659 mL 1.9318 mL 4.8294 mL
20 mM 0.1449 mL 0.7244 mL 1.4488 mL 3.6220 mL
25 mM 0.1159 mL 0.5795 mL 1.1591 mL 2.8976 mL
30 mM 0.0966 mL 0.4829 mL 0.9659 mL 2.4147 mL
40 mM 0.0724 mL 0.3622 mL 0.7244 mL 1.8110 mL
50 mM 0.0580 mL 0.2898 mL 0.5795 mL 1.4488 mL
60 mM 0.0483 mL 0.2415 mL 0.4829 mL 1.2073 mL
80 mM 0.0362 mL 0.1811 mL 0.3622 mL 0.9055 mL
100 mM 0.0290 mL 0.1449 mL 0.2898 mL 0.7244 mL
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BVFP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BVFP357158-20-4Neurotensin ReceptorPGRNSORT1PGRN endocytosispeptideInhibitorinhibitorinhibit

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