2. Gene
  3. Aurka - aurora kinase A Gene

Aurka - aurora kinase A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IAK; Ark1; Ayk1; IAK1; Stk6; AIRK1; ARK-1; Aurora-A

Gene ID: 20878 | Gene type: protein coding

About Aurka

Chromosome 2: 172,198,110-172,212,455 reverse strand.GRCm39:CM000995.3

This gene has 5 transcripts (splice variants), 236 orthologues, 2 paralogues and is associated with 34 phenotypes. Broad expression in liver E14.5 (RPKM 39.2), liver E14 (RPKM 37.7) and 15 other tissues.

Summary

Enables histone serine kinase activity and ubiquitin protein Ligase binding activity. Acts upstream of or within several processes, including microtubule Cytoskeleton organization; positive regulation of oocyte maturation; and protein localization to centrosome. Located in axon hillock; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; bone; brain; eye; and genitourinary system. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian cancer; and uterine Cancer. Orthologous to human AURKA (Aurora Kinase A). [provided by Alliance of Genome Resources, Apr 2022]

Aurka Products(2)

mRNA Protein Name
NM_011497.4 NP_035627.1 aurora kinase A isoform a
NM_001291185.1 NP_001278114.1 aurora kinase A isoform b

Aurka Protein Structure

PKc_like

PKc_like: cl21453 (117 - 373)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
Protein Preferred Names Protein Names

aurora kinase A

aurora 2

aurora A

aurora family kinase 1

aurora-related kinase 1

aurora/IPL1-related kinase 1

ipl1- and aurora-related kinase 1

serine/threonine kinase 6

serine/threonine-protein kinase 15

serine/threonine-protein kinase 6

serine/threonine-protein kinase Ayk1

serine/threonine-protein kinase aurora-A

Related Agents

Pre-clinical Phase
Bioactive Molecules (21)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103645 GW779439X 99.85% Unkown
HY-112273 CD532 Inhibitor 98.78% Unkown
HY-112273A CD532 hydrochloride Inhibitor 99.62% Unkown
HY-157396 JAB-2485 98.11% Unkown
HY-137344A dAURK-4 hydrochloride Inhibitor 99.44% Unkown
HY-125956 Aurkin A Inhibitor ≥98.0% Unkown
HY-100865 BPR1K871 Inhibitor 99.12% Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-158038 AurkA allosteric-IN-1 Inhibitor / Unkown
HY-125090 PHA-680626 / Unkown
HY-137344 dAURK-4 Inhibitor / Unkown
HY-147703 Aurora kinase inhibitor-9 Inhibitor / Unkown
HY-155464 VEGFR-2/AURKA-IN-1 Chemical / Unkown
HY-161407 AURKA-IN-1 Inhibitor / Unkown
HY-162469 6K465 Inhibitor / Unkown
HY-162837 AURKA against 1 Inhibitor / Unkown
HY-168540 PROTAC MPS1 degrader 1 Degrader / Unkown
HY-168543 PROTAC MPS1 degrader 2 Degrader / Unkown
HY-RS01266 AURKA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01267 Aurka Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01268 Aurka Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aurka NCBI NCBI:6790