CD532 hydrochloride

Name: CD532 hydrochloride
Brand: MedChemExpress
SKU: HY-112273A
Rating: 4.5 (1 reviews)

Cat. No.: HY-112273A Purity: 99.62%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC₅₀ of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer.

For research use only. We do not sell to patients.

CD532 hydrochloride Chemical Structure

CAS No. : 2926498-81-7

Size	Price	Stock	Quantity
5 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CD532 hydrochloride:

CD532 Get quote

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•Related Screening Libraries:

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View All Aurora Kinase Isoform Specific Products:

View All Isoforms

Aurora Kinase Aurora A Aurora B Aurora C

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vivo

Animal Model:	Homozygous nu/nu mice with SHH-subtype MYCN-expressing medulloblastoma^[1]
Dosage:	25 mg/kg
Administration:	I.p. twice weekly for 3 weeks
Result:	Decreased the level of MYCN protein and tumor volume and increases survival.

Molecular Weight

558.99

Formula

C₂₆H₂₆ClF₃N₈O

CAS No.

2926498-81-7

Appearance

Solid

Color

White to off-white

SMILES

FC(F)(F)C1=CC=CC(NC(NC2=CC=C(NC3=NC=CC(NC4=NNC(C5CCCC5)=C4)=N3)C=C2)=O)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (178.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7889 mL	8.9447 mL	17.8894 mL
5 mM	0.3578 mL	1.7889 mL	3.5779 mL
10 mM	0.1789 mL	0.8945 mL	1.7889 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (4.47 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.62%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (245 KB) HNMR (333 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Gustafson WC, et, al. Drugging MYCN through an allosteric transition in Aurora kinase A. Cancer Cell. 2014 Sep 8;26(3):414-427. [Content Brief]

[2]. Lee JK, et, al. N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell. 2016 Apr 11;29(4):536-547. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7889 mL	8.9447 mL	17.8894 mL	44.7235 mL
	5 mM	0.3578 mL	1.7889 mL	3.5779 mL	8.9447 mL
	10 mM	0.1789 mL	0.8945 mL	1.7889 mL	4.4724 mL
	15 mM	0.1193 mL	0.5963 mL	1.1926 mL	2.9816 mL
	20 mM	0.0894 mL	0.4472 mL	0.8945 mL	2.2362 mL
	25 mM	0.0716 mL	0.3578 mL	0.7156 mL	1.7889 mL
	30 mM	0.0596 mL	0.2982 mL	0.5963 mL	1.4908 mL
	40 mM	0.0447 mL	0.2236 mL	0.4472 mL	1.1181 mL
	50 mM	0.0358 mL	0.1789 mL	0.3578 mL	0.8945 mL
	60 mM	0.0298 mL	0.1491 mL	0.2982 mL	0.7454 mL
	80 mM	0.0224 mL	0.1118 mL	0.2236 mL	0.5590 mL
	100 mM	0.0179 mL	0.0894 mL	0.1789 mL	0.4472 mL