ESD - esterase D Gene

Homo sapiens

Also known as FGH

Gene ID: 2098 | Gene type: protein coding

About ESD

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:46,771,256-46,797,700 (from NCBI)

This gene has 5 transcripts (splice variants) and 245 orthologues. Ubiquitous expression in thyroid (RPKM 31.6), ovary (RPKM 31.3) and 25 other tissues.

Summary

This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded Enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009]

ESD Products(1)

mRNA	Protein	Name
NM_001984.2	NP_001975.1	S-formylglutathione hydrolase

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables hydrolase activity, acting on ester bonds	IDA IDA: Inferred from direct assay	19126594	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ESD Protein Structure

Esterase

0
100
200
282 a.a.

Protein Preferred Names

Protein Names

S-formylglutathione hydrolase

esterase 10

ESD Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ESD	P10768	FSD2	Homo sapiens	A1L4K1	Y2H Array	25416956
Intra	ESD	P10768	ESD	Homo sapiens	P10768	Y2H Prey Pooling	32296183
Intra	ESD	P10768	PLCG2	Homo sapiens	P16885	Y2H Array	25814554
Intra	ESD	P10768	FSD2	Homo sapiens	A1L4K1	Y2H Array	32296183
Intra	ESD	P10768	ESD	Homo sapiens	P10768	Y2H Array	31515488
Intra	ESD	P10768	FSD2	Homo sapiens	A1L4K1	Y2H Array	31515488
Intra	ESD	P10768	ESD	Homo sapiens	P10768	Validated Y2H	32296183
Intra	ESD	P10768	CRK	Homo sapiens	P46108	Y2H Array	25814554
Intra	ESD	P10768	FSD2	Homo sapiens	A1L4K1	Validated Y2H	25416956
Intra	ESD	P10768	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	32296183
Intra	ESD	P10768	ESD	Homo sapiens	P10768	Y2H Array	32296183
Intra	ESD	P10768	ESD	Homo sapiens	P10768	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ESD Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70279	Esterase D/FGH Protein, Human (His)	AAH01169.1 (M1-A282)	≥95%

Related Diseases

Diseases

Alias

Wilson Disease

Hepatolenticular Degeneration	WD
Wilson'S Disease	WND
Westphal-Strumpell Syndrome	Copper Storage Disease
Cerebral Pseudosclerosis	Westphal Pseudosclerosis
Hepatolenticular Degeneration Syndrome	Copper Retention
Hepatocerebral Degeneration	Kinnier-Wilson Disease
Neurohepatic Degeneration	Progressive Hepatolenticular Degeneration
Lenticular Degenerative Disease	Wilson'S Syndrome
Lenticular Syndrome

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Cervical Non-Keratinizing Squamous Cell Carcinoma

Dermoid Cyst Of Ovary

Dermoid Cyst	Ovarian Dermoid Cyst
Teratoma, Ovarian

Bilateral Retinoblastoma

Familial Retinoblastoma

Hereditary Retinoblastoma

Retinoblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04524	ESD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ESD	MGD	MGI:95421
Felis catus	ESD	VGNC	VGNC:102197
Bos taurus	ESD	VGNC	VGNC:28600
Rattus norvegicus	ESD	RGD	RGD:1592114
Canis familiaris	ESD	VGNC	VGNC:40472
Macaca mulatta	ESD	VGNC	VGNC:103814
Others	ESD	NCBI

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