2. Gene
  3. CRK - CRK proto-oncogene, adaptor protein Gene

CRK - CRK proto-oncogene, adaptor protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as p38; CRKII

Gene ID: 1398 | Gene type: protein coding

About CRK

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,420,693-1,456,232 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 27.5), thyroid (RPKM 27.2) and 25 other tissues.

Summary

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

CRK Products(2)

mRNA Protein Name
NM_005206.5 NP_005197.3 adapter molecule crk isoform b
NM_016823.4 NP_058431.2 adapter molecule crk isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SH2 domain binding IPI
IPI: Inferred from physical interaction
9472046 GOA
enables SH3 domain binding IPI
IPI: Inferred from physical interaction
12384576 GOA
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
11870224 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
18722344 GOA
enables phosphotyrosine residue binding IPI
IPI: Inferred from physical interaction
20624904 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7561682 GOA
enables protein phosphorylated amino acid binding IDA
IDA: Inferred from direct assay
12384576 GOA
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
12384576 GOA
enables signaling adaptor activity IDA
IDA: Inferred from direct assay
12384576 GOA
Biological Process GO Annotation Evidence Reference Source
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
31311869 GOA
involved in ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
11870224 GOA
involved in negative regulation of cell motility IDA
IDA: Inferred from direct assay
17515907 GOA
involved in negative regulation of cell motility IMP
IMP: Inferred from mutant phenotype
17515907 GOA
involved in negative regulation of wound healing IDA
IDA: Inferred from direct assay
17515907 GOA
involved in negative regulation of wound healing IMP
IMP: Inferred from mutant phenotype
17515907 GOA
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
17515907 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
19004829 GOA
involved in regulation of GTPase activity IDA
IDA: Inferred from direct assay
11870224 GOA
involved in regulation of actin cytoskeleton organization IDA
IDA: Inferred from direct assay
11870224 GOA
NOT involved in regulation of cell motility IDA
IDA: Inferred from direct assay
17515907 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
17515907 GOA
involved in regulation of intracellular signal transduction IDA
IDA: Inferred from direct assay
12384576 GOA
involved in regulation of signal transduction IDA
IDA: Inferred from direct assay
17515907 GOA
NOT involved in regulation of wound healing IDA
IDA: Inferred from direct assay
17515907 GOA
Cellular Component GO Annotation Evidence Reference Source
part of protein-containing complex IPI
IPI: Inferred from physical interaction
12384576 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRK Protein Structure

SH2

SH2: SH2 domain (13 - 104)

SH3_1

SH3_1: SH3 domain (138 - 184)

SH3_2

SH3_2: Variant SH3 domain (239 - 292)

  • 0
  • 100
  • 200
  • 304 a.a.
Protein Preferred Names Protein Names

adapter molecule crk

proto-oncogene c-Crk

CRK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra CRK P46108 ABL2 Homo sapiens P42684
Protein Kinase Assay
15886098
Intra CRK P46108 ABL2 Homo sapiens P42684
Anti Tag CoIP
33961781
Intra CRK P46108 ABL2 Homo sapiens P42684
TAP
19380743
Intra CRK P46108 FLACC1 Homo sapiens Q96Q35-2
Y2H Prey Pooling
26871637
Intra CRK P46108 FLACC1 Homo sapiens Q96Q35-2
Validated Y2H
26871637
Intra CRK P46108 FLACC1 Homo sapiens Q96Q35-2
Y2H Array
26871637
Intra CRK P46108 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
26871637
Intra CRK P46108 TP53BP2 Homo sapiens Q05BL1
Validated Y2H
26871637
Intra CRK P46108 TP53BP2 Homo sapiens Q05BL1
Y2H Array
26871637
Intra CRK P46108 MAP4K5 Homo sapiens Q9Y4K4
Pull Down
9788432
Intra CRK P46108 MAP4K5 Homo sapiens Q9Y4K4
TAP
19380743
Intra CRK P46108 MAP4K5 Homo sapiens Q9Y4K4
CoIP
9788432
Intra CRK P46108 KIT Homo sapiens P10721
FPS
24728074
Intra CRK P46108 RIN3 Homo sapiens Q8TB24
Y2H Array
25814554
Intra CRK P46108 BICRA Homo sapiens Q9NZM4
Phage Display
35044719
Intra CRK P46108 ELK3 Homo sapiens P41970
BiFC
26871637
Intra CRK P46108 ELK3 Homo sapiens P41970
Y2H Prey Pooling
26871637
Intra CRK P46108 ELK3 Homo sapiens P41970
Y2H Array
26871637
Intra CRK P46108 ELK3 Homo sapiens P41970
Validated Y2H
26871637
Intra CRK P46108 DOCK5 Homo sapiens Q9H7D0
Anti Tag CoIP
31980649
Intra CRK P46108 DOCK5 Homo sapiens Q9H7D0
Phage Display
35044719
Intra CRK P46108 DOCK5 Homo sapiens Q9H7D0
Anti Tag CoIP
33961781
Intra CRK P46108 ASAP3 Homo sapiens Q8TDY4
Y2H Prey Pooling
26871637
Intra CRK P46108 ASAP3 Homo sapiens Q8TDY4
Anti Tag CoIP
33961781
Intra CRK P46108 ASAP3 Homo sapiens Q8TDY4
Validated Y2H
26871637
Intra CRK P46108 ASAP3 Homo sapiens Q8TDY4
BiFC
26871637
Intra CRK P46108 ASAP3 Homo sapiens Q8TDY4
Y2H Array
26871637
Intra CRK P46108 ASAP3 Homo sapiens Q8TDY4
TAP
19380743
Intra CRK P46108 PDGFRA Homo sapiens P16234
Enzymatic Study
9546424
Intra CRK P46108 PDGFRA Homo sapiens P16234
Pull Down
10733900
Intra CRK P46108 EGFR Homo sapiens P00533
Protein Array
16273093
Intra CRK P46108 SOS1 Homo sapiens Q07889
Anti Tag CoIP
31980649
Intra CRK P46108 SOS1 Homo sapiens Q07889
Anti Tag CoIP
33961781
Intra CRK P46108 SOS1 Homo sapiens Q07889
TAP
19380743
Intra CRK P46108 SOS2 Homo sapiens Q07890
Anti Tag CoIP
33961781
Intra CRK P46108 SOS2 Homo sapiens Q07890
Peptide Array
17474147
Intra CRK P46108 SOS2 Homo sapiens Q07890
TAP
19380743
Intra CRK P46108 ARHGAP32 Homo sapiens A7KAX9
Anti Tag CoIP
31980649
Intra CRK P46108 ARHGAP32 Homo sapiens A7KAX9
Phage Display
35044719
Intra CRK P46108 GAREM1 Homo sapiens Q9H706
Validated Y2H
25814554
Intra CRK P46108 GAREM1 Homo sapiens Q9H706
Phage Display
35044719
Intra CRK P46108 ASAP1 Homo sapiens Q9ULH1
Anti Tag CoIP
33961781
Intra CRK P46108 ASAP1 Homo sapiens Q9ULH1
Anti Tag CoIP
31980649
Intra CRK P46108 ASAP1 Homo sapiens Q9ULH1
Peptide Array
17474147
Intra CRK P46108 FLNA Homo sapiens P21333
Peptide Array
17474147
Intra CRK P46108 FLNA Homo sapiens P21333
PLA
25241761
Intra CRK P46108 IRS4 Homo sapiens O14654
Pull Down
11316748
Intra CRK P46108 IRS4 Homo sapiens O14654
CoIP
11316748
Intra CRK P46108 PSMC6 Homo sapiens P62333
Y2H Prey Pooling
26871637
Intra CRK P46108 PSMC6 Homo sapiens P62333
Validated Y2H
26871637
Intra CRK P46108 PSMC6 Homo sapiens P62333
Y2H Array
26871637
Intra CRK P46108 PSMC6 Homo sapiens P62333
Validated Y2H
32296183
Intra CRK P46108 PSMC6 Homo sapiens P62333
Y2H Pooling
16189514
Intra CRK P46108 ABL1 Homo sapiens P00519
Anti Tag CoIP
33961781
Intra CRK P46108 ABL1 Homo sapiens P00519
Anti Tag CoIP
31980649
Intra CRK P46108 SAXO1 Homo sapiens Q8IYX7
Validated Y2H
25416956
Intra CRK P46108 DOCK1 Homo sapiens Q14185
Anti Tag CoIP
33961781
Intra CRK P46108 DOCK1 Homo sapiens Q14185
Peptide Array
17474147
Intra CRK P46108 DOCK1 Homo sapiens Q14185
Anti Tag CoIP
31980649
Intra CRK P46108 DOCK1 Homo sapiens Q14185
Phage Display
35044719
Intra CRK P46108 GAB1 Homo sapiens Q13480
FPS
24728074
Intra CRK P46108 CBL Homo sapiens P22681
Anti Tag CoIP
31980649
Intra CRK P46108 CBL Homo sapiens P22681
Anti Bait CoIP
15581361
Intra CRK P46108 CBL Homo sapiens P22681
Validated Y2H
25814554
Intra CRK P46108 CBL Homo sapiens P22681
CoIP
8621483
Intra CRK P46108 CBL Homo sapiens P22681
TAP
19380743
Intra CRK P46108 CBL Homo sapiens P22681
CoIP
8626543
Intra CRK P46108 CBL Homo sapiens P22681
Anti Tag CoIP
33961781
Intra CRK P46108 BCAR1 Homo sapiens P56945
Anti Bait CoIP
12799422
Intra CRK P46108 BCAR1 Homo sapiens P56945
Anti Bait CoIP
17038317
Intra CRK P46108 BCAR1 Homo sapiens P56945
Anti Tag CoIP
31980649
Intra CRK P46108 PTK2 Homo sapiens Q05397
Anti Bait CoIP
7561682
Intra CRK P46108 PTK2 Homo sapiens Q05397
Validated Y2H
25814554
Intra CRK P46108 PTK2 Homo sapiens Q05397
Y2H Array
25814554
Intra CRK P46108 PTPN4 Homo sapiens P29074
Y2H
21988832
Intra CRK P46108 PTPN4 Homo sapiens P29074
Confocal
21988832
Intra CRK P46108 DPPA4 Homo sapiens Q7L190
Validated Y2H
26871637
Intra CRK P46108 DPPA4 Homo sapiens Q7L190
Y2H Pooling
16189514
Intra CRK P46108 DPPA4 Homo sapiens Q7L190
Y2H Prey Pooling
26871637
Intra CRK P46108 DPPA4 Homo sapiens Q7L190
Y2H Array
26871637
Intra CRK P46108 ERBB3 Homo sapiens P21860
Protein Array
16273093
Intra CRK P46108 USP53 Homo sapiens Q70EK8
Validated Y2H
27107012
Intra CRK P46108 USP53 Homo sapiens Q70EK8
Validated Y2H
26871637
Intra CRK P46108 USP53 Homo sapiens Q70EK8
Validated Y2H
32296183
Intra CRK P46108 USP53 Homo sapiens Q70EK8
Y2H Array
26871637
Intra CRK P46108 USP53 Homo sapiens Q70EK8
Y2H Prey Pooling
26871637
Intra CRK P46108 CBLB Homo sapiens Q13191
TAP
19380743
Intra CRK P46108 CBLB Homo sapiens Q13191
Y2H Array
25814554
Intra CRK P46108 CBLB Homo sapiens Q13191
Anti Tag CoIP
33961781
Intra CRK P46108 PPFIBP2 Homo sapiens Q8ND30
Y2H Pooling
19447967
Intra CRK P46108 PPFIBP2 Homo sapiens Q8ND30
Y2H Prey Pooling
26871637
Intra CRK P46108 PPFIBP2 Homo sapiens Q8ND30
Validated Y2H
26871637
Intra CRK P46108 PPFIBP2 Homo sapiens Q8ND30
Y2H Array
26871637
Intra CRK P46108 PPFIBP2 Homo sapiens Q8ND30
Anti Tag CoIP
33961781
Intra CRK P46108 BUB1 Homo sapiens O43683
Phage Display
35044719
Intra CRK P46108 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Intra CRK P46108 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Intra CRK P46108 SPEN Homo sapiens Q96T58
Phage Display
35044719
Intra CRK P46108 WDR83 Homo sapiens Q9BRX9
Phage Display
35044719
Intra CRK P46108 PIK3R3 Homo sapiens Q92569
Y2H Array
25814554
Intra CRK P46108 PIK3R3 Homo sapiens Q92569
TAP
19380743
Intra CRK P46108 PIK3R3 Homo sapiens Q92569
Validated Y2H
25814554
Intra CRK P46108 MAP4K1 Homo sapiens Q92918
Pull Down
9788432
Intra CRK P46108 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra CRK P46108 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra CRK P46108 ATXN1 Homo sapiens P54253
Y2H Array
16713569
Intra CRK P46108 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra CRK P46108 C1orf94 Homo sapiens Q6P1W5
Y2H Prey Pooling
26871637
Intra CRK P46108 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
26871637
Intra CRK P46108 C1orf94 Homo sapiens Q6P1W5
Y2H Array
26871637
Intra CRK P46108 RAPGEF1 Homo sapiens Q13905
Anti Tag CoIP
33961781
Intra CRK P46108 RAPGEF1 Homo sapiens Q13905
TAP
19380743
Intra CRK P46108 RAPGEF1 Homo sapiens Q13905
Anti Tag CoIP
31980649
Intra CRK P46108 RAPGEF1 Homo sapiens Q13905
CoIP
8621483
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome

17p13.3 Duplication Syndrome

17p13.3 Microduplication Syndrome

Trisomy 17p13.3

Chromosome 17p13.3 Centromeric Duplication Syndrome

Dup(17)(P13.3)
Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome

Mds

MDLS

Miller Dieker Syndrome

Classical Lissencephaly Syndrome

Lissencephaly Due To 17p13.3 Deletion

Monosomy 17p13.3

Telomeric Deletion 17p

Classical Lissencephaly
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112622 GSK3186899 Inhibitor 98.61% Phase 1
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112346 RGB-286147 98.60% Unkown
HY-RS16222 Crk Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-143322 CRK12-IN-2 Inhibitor / Unkown
HY-145812 CRK12-IN-1 Inhibitor / Unkown
HY-RS03184 CRK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CRK VGNC VGNC:54290
Felis catus CRK VGNC VGNC:98896
Bos taurus CRK VGNC VGNC:27716
Rattus norvegicus CRK RGD RGD:2405
Macaca mulatta CRK VGNC VGNC:99140
Mus musculus CRK MGD MGI:88508
Others CRK NCBI