CRK - CRK proto-oncogene, adaptor protein Gene

Homo sapiens

Also known as p38; CRKII

Gene ID: 1398 | Gene type: protein coding

About CRK

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,420,693-1,456,232 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 27.5), thyroid (RPKM 27.2) and 25 other tissues.

Summary

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

CRK Products(2)

mRNA	Protein	Name
NM_005206.5	NP_005197.3	adapter molecule crk isoform b
NM_016823.4	NP_058431.2	adapter molecule crk isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	9472046	GOA
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	12384576	GOA
enables ephrin receptor binding	IPI IPI: Inferred from physical interaction	11870224	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	18722344	GOA
enables phosphotyrosine residue binding	IPI IPI: Inferred from physical interaction	20624904	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7561682	GOA
enables protein phosphorylated amino acid binding	IDA IDA: Inferred from direct assay	12384576	GOA
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	12384576	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	12384576	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	31311869	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	11870224	GOA
involved in negative regulation of cell motility	IDA IDA: Inferred from direct assay	17515907	GOA
involved in negative regulation of cell motility	IMP IMP: Inferred from mutant phenotype	17515907	GOA
involved in negative regulation of wound healing	IDA IDA: Inferred from direct assay	17515907	GOA
involved in negative regulation of wound healing	IMP IMP: Inferred from mutant phenotype	17515907	GOA
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	17515907	GOA
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	19004829	GOA
involved in regulation of GTPase activity	IDA IDA: Inferred from direct assay	11870224	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	11870224	GOA
NOT involved in regulation of cell motility	IDA IDA: Inferred from direct assay	17515907	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	17515907	GOA
involved in regulation of intracellular signal transduction	IDA IDA: Inferred from direct assay	12384576	GOA
involved in regulation of signal transduction	IDA IDA: Inferred from direct assay	17515907	GOA
NOT involved in regulation of wound healing	IDA IDA: Inferred from direct assay	17515907	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IPI IPI: Inferred from physical interaction	12384576	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRK Protein Structure

SH2

SH3_1

SH3_2

0
100
200
304 a.a.

Protein Preferred Names

Protein Names

adapter molecule crk

proto-oncogene c-Crk

CRK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CRK	P46108	ABL2	Homo sapiens	P42684	Protein Kinase Assay	15886098
Intra	CRK	P46108	ABL2	Homo sapiens	P42684	Anti Tag CoIP	33961781
Intra	CRK	P46108	ABL2	Homo sapiens	P42684	TAP	19380743
Intra	CRK	P46108	FLACC1	Homo sapiens	Q96Q35-2	Y2H Prey Pooling	26871637
Intra	CRK	P46108	FLACC1	Homo sapiens	Q96Q35-2	Validated Y2H	26871637
Intra	CRK	P46108	FLACC1	Homo sapiens	Q96Q35-2	Y2H Array	26871637
Intra	CRK	P46108	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	26871637
Intra	CRK	P46108	TP53BP2	Homo sapiens	Q05BL1	Validated Y2H	26871637
Intra	CRK	P46108	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	26871637
Intra	CRK	P46108	MAP4K5	Homo sapiens	Q9Y4K4	Pull Down	9788432
Intra	CRK	P46108	MAP4K5	Homo sapiens	Q9Y4K4	TAP	19380743
Intra	CRK	P46108	MAP4K5	Homo sapiens	Q9Y4K4	CoIP	9788432
Intra	CRK	P46108	KIT	Homo sapiens	P10721	FPS	24728074
Intra	CRK	P46108	RIN3	Homo sapiens	Q8TB24	Y2H Array	25814554
Intra	CRK	P46108	BICRA	Homo sapiens	Q9NZM4	Phage Display	35044719
Intra	CRK	P46108	ELK3	Homo sapiens	P41970	BiFC	26871637
Intra	CRK	P46108	ELK3	Homo sapiens	P41970	Y2H Prey Pooling	26871637
Intra	CRK	P46108	ELK3	Homo sapiens	P41970	Y2H Array	26871637
Intra	CRK	P46108	ELK3	Homo sapiens	P41970	Validated Y2H	26871637
Intra	CRK	P46108	DOCK5	Homo sapiens	Q9H7D0	Anti Tag CoIP	31980649
Intra	CRK	P46108	DOCK5	Homo sapiens	Q9H7D0	Phage Display	35044719
Intra	CRK	P46108	DOCK5	Homo sapiens	Q9H7D0	Anti Tag CoIP	33961781
Intra	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	Y2H Prey Pooling	26871637
Intra	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	Anti Tag CoIP	33961781
Intra	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	Validated Y2H	26871637
Intra	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	BiFC	26871637
Intra	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	Y2H Array	26871637
Intra	CRK	P46108	ASAP3	Homo sapiens	Q8TDY4	TAP	19380743
Intra	CRK	P46108	PDGFRA	Homo sapiens	P16234	Enzymatic Study	9546424
Intra	CRK	P46108	PDGFRA	Homo sapiens	P16234	Pull Down	10733900
Intra	CRK	P46108	EGFR	Homo sapiens	P00533	Protein Array	16273093
Intra	CRK	P46108	SOS1	Homo sapiens	Q07889	Anti Tag CoIP	31980649
Intra	CRK	P46108	SOS1	Homo sapiens	Q07889	Anti Tag CoIP	33961781
Intra	CRK	P46108	SOS1	Homo sapiens	Q07889	TAP	19380743
Intra	CRK	P46108	SOS2	Homo sapiens	Q07890	Anti Tag CoIP	33961781
Intra	CRK	P46108	SOS2	Homo sapiens	Q07890	Peptide Array	17474147
Intra	CRK	P46108	SOS2	Homo sapiens	Q07890	TAP	19380743
Intra	CRK	P46108	ARHGAP32	Homo sapiens	A7KAX9	Anti Tag CoIP	31980649
Intra	CRK	P46108	ARHGAP32	Homo sapiens	A7KAX9	Phage Display	35044719
Intra	CRK	P46108	GAREM1	Homo sapiens	Q9H706	Validated Y2H	25814554
Intra	CRK	P46108	GAREM1	Homo sapiens	Q9H706	Phage Display	35044719
Intra	CRK	P46108	ASAP1	Homo sapiens	Q9ULH1	Anti Tag CoIP	33961781
Intra	CRK	P46108	ASAP1	Homo sapiens	Q9ULH1	Anti Tag CoIP	31980649
Intra	CRK	P46108	ASAP1	Homo sapiens	Q9ULH1	Peptide Array	17474147
Intra	CRK	P46108	FLNA	Homo sapiens	P21333	Peptide Array	17474147
Intra	CRK	P46108	FLNA	Homo sapiens	P21333	PLA	25241761
Intra	CRK	P46108	IRS4	Homo sapiens	O14654	Pull Down	11316748
Intra	CRK	P46108	IRS4	Homo sapiens	O14654	CoIP	11316748
Intra	CRK	P46108	PSMC6	Homo sapiens	P62333	Y2H Prey Pooling	26871637
Intra	CRK	P46108	PSMC6	Homo sapiens	P62333	Validated Y2H	26871637
Intra	CRK	P46108	PSMC6	Homo sapiens	P62333	Y2H Array	26871637
Intra	CRK	P46108	PSMC6	Homo sapiens	P62333	Validated Y2H	32296183
Intra	CRK	P46108	PSMC6	Homo sapiens	P62333	Y2H Pooling	16189514
Intra	CRK	P46108	ABL1	Homo sapiens	P00519	Anti Tag CoIP	33961781
Intra	CRK	P46108	ABL1	Homo sapiens	P00519	Anti Tag CoIP	31980649
Intra	CRK	P46108	SAXO1	Homo sapiens	Q8IYX7	Validated Y2H	25416956
Intra	CRK	P46108	DOCK1	Homo sapiens	Q14185	Anti Tag CoIP	33961781
Intra	CRK	P46108	DOCK1	Homo sapiens	Q14185	Peptide Array	17474147
Intra	CRK	P46108	DOCK1	Homo sapiens	Q14185	Anti Tag CoIP	31980649
Intra	CRK	P46108	DOCK1	Homo sapiens	Q14185	Phage Display	35044719
Intra	CRK	P46108	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	CRK	P46108	CBL	Homo sapiens	P22681	Anti Tag CoIP	31980649
Intra	CRK	P46108	CBL	Homo sapiens	P22681	Anti Bait CoIP	15581361
Intra	CRK	P46108	CBL	Homo sapiens	P22681	Validated Y2H	25814554
Intra	CRK	P46108	CBL	Homo sapiens	P22681	CoIP	8621483
Intra	CRK	P46108	CBL	Homo sapiens	P22681	TAP	19380743
Intra	CRK	P46108	CBL	Homo sapiens	P22681	CoIP	8626543
Intra	CRK	P46108	CBL	Homo sapiens	P22681	Anti Tag CoIP	33961781
Intra	CRK	P46108	BCAR1	Homo sapiens	P56945	Anti Bait CoIP	12799422
Intra	CRK	P46108	BCAR1	Homo sapiens	P56945	Anti Bait CoIP	17038317
Intra	CRK	P46108	BCAR1	Homo sapiens	P56945	Anti Tag CoIP	31980649
Intra	CRK	P46108	PTK2	Homo sapiens	Q05397	Anti Bait CoIP	7561682
Intra	CRK	P46108	PTK2	Homo sapiens	Q05397	Validated Y2H	25814554
Intra	CRK	P46108	PTK2	Homo sapiens	Q05397	Y2H Array	25814554
Intra	CRK	P46108	PTPN4	Homo sapiens	P29074	Y2H	21988832
Intra	CRK	P46108	PTPN4	Homo sapiens	P29074	Confocal	21988832
Intra	CRK	P46108	DPPA4	Homo sapiens	Q7L190	Validated Y2H	26871637
Intra	CRK	P46108	DPPA4	Homo sapiens	Q7L190	Y2H Pooling	16189514
Intra	CRK	P46108	DPPA4	Homo sapiens	Q7L190	Y2H Prey Pooling	26871637
Intra	CRK	P46108	DPPA4	Homo sapiens	Q7L190	Y2H Array	26871637
Intra	CRK	P46108	ERBB3	Homo sapiens	P21860	Protein Array	16273093
Intra	CRK	P46108	USP53	Homo sapiens	Q70EK8	Validated Y2H	27107012
Intra	CRK	P46108	USP53	Homo sapiens	Q70EK8	Validated Y2H	26871637
Intra	CRK	P46108	USP53	Homo sapiens	Q70EK8	Validated Y2H	32296183
Intra	CRK	P46108	USP53	Homo sapiens	Q70EK8	Y2H Array	26871637
Intra	CRK	P46108	USP53	Homo sapiens	Q70EK8	Y2H Prey Pooling	26871637
Intra	CRK	P46108	CBLB	Homo sapiens	Q13191	TAP	19380743
Intra	CRK	P46108	CBLB	Homo sapiens	Q13191	Y2H Array	25814554
Intra	CRK	P46108	CBLB	Homo sapiens	Q13191	Anti Tag CoIP	33961781
Intra	CRK	P46108	PPFIBP2	Homo sapiens	Q8ND30	Y2H Pooling	19447967
Intra	CRK	P46108	PPFIBP2	Homo sapiens	Q8ND30	Y2H Prey Pooling	26871637
Intra	CRK	P46108	PPFIBP2	Homo sapiens	Q8ND30	Validated Y2H	26871637
Intra	CRK	P46108	PPFIBP2	Homo sapiens	Q8ND30	Y2H Array	26871637
Intra	CRK	P46108	PPFIBP2	Homo sapiens	Q8ND30	Anti Tag CoIP	33961781
Intra	CRK	P46108	BUB1	Homo sapiens	O43683	Phage Display	35044719
Intra	CRK	P46108	TERF2IP	Homo sapiens	Q9NYB0	Pull Down	21044950
Intra	CRK	P46108	TERF2IP	Homo sapiens	Q9NYB0	BiFC	21044950
Intra	CRK	P46108	SPEN	Homo sapiens	Q96T58	Phage Display	35044719
Intra	CRK	P46108	WDR83	Homo sapiens	Q9BRX9	Phage Display	35044719
Intra	CRK	P46108	PIK3R3	Homo sapiens	Q92569	Y2H Array	25814554
Intra	CRK	P46108	PIK3R3	Homo sapiens	Q92569	TAP	19380743
Intra	CRK	P46108	PIK3R3	Homo sapiens	Q92569	Validated Y2H	25814554
Intra	CRK	P46108	MAP4K1	Homo sapiens	Q92918	Pull Down	9788432
Intra	CRK	P46108	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	CRK	P46108	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	CRK	P46108	ATXN1	Homo sapiens	P54253	Y2H Array	16713569
Intra	CRK	P46108	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	CRK	P46108	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	26871637
Intra	CRK	P46108	C1orf94	Homo sapiens	Q6P1W5	Validated Y2H	26871637
Intra	CRK	P46108	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	26871637
Intra	CRK	P46108	RAPGEF1	Homo sapiens	Q13905	Anti Tag CoIP	33961781
Intra	CRK	P46108	RAPGEF1	Homo sapiens	Q13905	TAP	19380743
Intra	CRK	P46108	RAPGEF1	Homo sapiens	Q13905	Anti Tag CoIP	31980649
Intra	CRK	P46108	RAPGEF1	Homo sapiens	Q13905	CoIP	8621483

Cross: Cross-species interaction Intra: Intraspecies interaction

CRK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80630	CRK Antibody (YA790)	WB	Human

Related Diseases

Diseases

Alias

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome	17p13.3 Duplication Syndrome
17p13.3 Microduplication Syndrome	Trisomy 17p13.3
Chromosome 17p13.3 Centromeric Duplication Syndrome	Dup(17)(P13.3)

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112622	GSK3186899	Inhibitor	98.61%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112346	RGB-286147		98.60%	Unkown
HY-RS16222	Crk Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-143322	CRK12-IN-2	Inhibitor	/	Unkown
HY-145812	CRK12-IN-1	Inhibitor	/	Unkown
HY-RS03184	CRK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CRK	VGNC	VGNC:54290
Felis catus	CRK	VGNC	VGNC:98896
Bos taurus	CRK	VGNC	VGNC:27716
Rattus norvegicus	CRK	RGD	RGD:2405
Macaca mulatta	CRK	VGNC	VGNC:99140
Mus musculus	CRK	MGD	MGI:88508
Others	CRK	NCBI

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