F5 - coagulation factor V Gene

Homo sapiens

Also known as FVL; PCCF; THPH2; RPRGL1

Gene ID: 2153 | Gene type: protein coding

About F5

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,511,951-169,586,481 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues, 35 paralogues and is associated with 10 phenotypes. Biased expression in liver (RPKM 48.1), placenta (RPKM 23.5) and 2 other tissues.

Summary

This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by Thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to Thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008]

F5 Products(1)

mRNA	Protein	Name
NM_000130.5	NP_000121.2	coagulation factor V preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	2844223	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

F5 Protein Structure

Cu-oxidase_3

F5_F8_type_C

0
400
800
1200
1600
2000
2224 a.a.

Protein Preferred Names

Protein Names

coagulation factor V

activated protein c cofactor

Related Diseases

Diseases

Alias

Factor V Deficiency

Parahemophilia	Labile Factor Deficiency
Proaccelerin Deficiency	Owren Disease
Owren Parahemophilia	Quebec Platelet Disorder
Deficiency, Labile	Hereditary Hypoproaccelerinaemia
Owren'S Disease	Congenital Factor V Deficiency
FA5D	Factor 5 Deficiency
Deficiency, Factor V

Thrombophilia Due To Activated Protein C Resistance

Activated Protein C Resistance	Apc Resistance
THPH2	Thrombophilia Due To Deficiency Of Activated Protein C Cofactor
Proc Cofactor Deficiency	Pccf Deficiency
Thrombophilia V	Thrombophilia, Susceptibility To, Due To Factor V Leiden
Thrombophilia Due To Factor V Leiden	Thrombophilia 2 Due To Activated Protein C Resistance
Thrombophilia, Susceptibility To, Due To Activated Protein C Resistance

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Pregnancy Loss, Recurrent 1

Pregnancy Loss, Recurrent, Susceptibility To, 1	Rpl
RPRGL1	Rprgl
Recurrent Miscarriage	Recurrent Spontaneous Abortion
Abortion, Spontaneous, Recurrent	Fetal Loss, Recurrent
Fetal Loss, Recurrent, Susceptibility To	Miscarriage, Recurrent
Embryonic Loss, Recurrent	Stillbirth, Recurrent
Pregnancy Loss, Recurrent, 1	Recurrent Embryonic Loss
Recurrent Fetal Loss	Recurrent Stillbirth
Spontaneous Recurrent Abortion	Miscarriage Recurrent
Pregnancy Loss, Recurrent, Susceptibility To, Type 1	Abortion, Habitual

Budd-Chiari Syndrome

Hepatic Vein Thrombosis	Chiari Syndrome
BDCHS	Membranous Obstruction Of The Inferior Vena Cava
Budd-Chiari Syndrome, Somatic	Movc
Budd-Chiari Syndrome, Susceptibility To, Somatic	Budd-Chiari Syndrome, Susceptibility To
Membranous Obstruction Of Inferior Vena Cava	Hepatic Vein Block
Obstruction Of Hepatic Veins	Hepatic Vein Obstruction
Hepatic Venous Block

Factor V Leiden Thrombophilia

Hereditary Resistance To Activated Protein C	Apc Resistance, Leiden Type
Thrombophilia Due To Activated Protein C Resistance

Bleeding Disorder, East Texas Type

Bdet	East Texas Bleeding Disorder

Thrombophilia

Hypercoagulability State

Protein C Deficiency

Hereditary Thrombophilia Due To Protein C Deficiency	Proc Deficiency
Congenital Thrombotic Disease, Due To Protein C Deficiency

Antithrombin Iii Deficiency

Hereditary Antithrombin Deficiency	Congenital Antithrombin Iii Deficiency
Hereditary Thrombophilia Due To Congenital Antithrombin Deficiency	AT3D
Thrombophilia Due To Antithrombin Iii Deficiency	Thph7
Hereditary Thrombophilia Due To Congenital Antithrombin 3 Deficiency	Thrombophilia 7 Due To Antithrombin Iii Deficiency
At Iii Deficiency	Congenital At-Iii Deficiency
Inherited Antithrombin Deficiency	Antithrombin 3 Deficiency
Antithrombin Deficiency	Antithrombin-Iii Deficiency
At-Iii Deficiency	Thrombophilia Due To Antithrombin-Iii Deficiency

Cerebral Sinovenous Thrombosis

Csvt

Thrombosis

Thrombosis Of Blood Vessel

Protein S Deficiency

Protein S Deficiency Disease

Hereditary Thrombophilia Due To Protein S Deficiency

Portal Vein Thrombosis

Phlebitis Of Portal Vein	Deep Vein Thrombosis Of Portal Vein
Portal Thrombosis	Pvt - [Portal Vein Thrombosis]
Portal Venous Thrombosis	Portal Venous Embolism
Portal Venous Obstruction	Portal Venous Block
Portal Vein Embolism	Portal Vein Block
Portal Obstruction	Portal Embolism
Portal Block	Hepatic Portal Vein Obstruction
Occlusion Of Hepatic Portal Vein	Portal Vein Obstruction

Retinal Vein Occlusion

Occlusion, Of Retinal Vein

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Antiphospholipid Syndrome

Antiphospholipid Antibody Syndrome	Hughes Syndrome
Familial Antiphospholipid Syndrome	Aps
Lupus Anticoagulant, Familial	Anti-Phospholipid Syndrome
Apls	Classic Apls
Classic Antiphospholipid Syndrome	Acromegaloid Facial Appearance Syndrome
Anticardiolipin Syndrome

Nonarteritic Anterior Ischemic Optic Neuropathy

Anterior Ischemic Optic Neuropathy	Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To
NAION	Non-Arteritic Anterior Ischemic Optic Neuropathy
Ischemic Optic Neuropathy	Aion
Optic Neuropathy, Ischemic	Naion, Susceptibility To
Optic Neuropathy, Anterior Ischemic	Optic Neuropathy, Anterior Ischemic, Susceptibility To
Non-Arteritic Anterior Ischaemic Optic Neuropathy	Nonarteritic Anterior Ischaemic Optic Neuropathy
Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To	Ion - [Ischemic Optic Neuropathy]
Neuropathic Ischaemia Of N.Opticus	Ischaemic Neuropathy Of Optic Nerve

Thrombophilia Due To Thrombin Defect

Venous Thromboembolism	Venous Thrombosis
Thrombophilia Due To Factor 2 Defect	Thromboembolism
THPH1	Thromboembolism, Susceptibility To
Venous Thromboembolism, Susceptibility To	Venous Thrombosis, Protection Against
Prothrombin-Related Thrombophilia	Hyperprothrombinemia
Venous Thrombosis, Susceptibility To	Thrombophilia 1 Due To Thrombin Defect
F2-Related Thrombophilia	Factor Ii-Related Thrombophilia
Prothrombin 20210g>A Thrombophilia	Prothrombin G20210a Thrombophilia
Prothrombin Thrombophilia

Disseminated Intravascular Coagulation

Defibrination Syndrome	Dic
Diffuse Or Disseminated Intravascular Coagulation	Fibrinolytic Purpura
Consumption Coagulopathy	Diffuse Intravascular Coagulation
Dic - [Disseminated Intravascular Coagulation]	Disseminated Intravascular Coagulopathy
Fibrinolysis Nos	Thrombolytic Purpura

Intracranial Thrombosis

Cerebral Thrombosis	Thrombosis Of Cerebral Veins
Cerebral Arterial Thrombosis

Factor Xii Deficiency

Hageman Factor Deficiency	Haf Deficiency
Factor Xii Deficiency Disease	F12 Deficiency
Deficiency, Hageman	Coagulation Factor 12 Deficiency
Factor 12 Deficiency	Congenital Factor Xii Deficiency
Congenital Hageman Factor Deficiency	FA12D
Factor Xii	Deficiency, Factor Xii

Retinal Vascular Occlusion

Retinal Vasc. Occlusion	Occlusion Of Retinal Vessels
Retinal Obstruction

Central Retinal Vein Occlusion

Crvo

Amaurosis Fugax

Transient Monocular Blindness	Momentary Blindness
Af - [Amaurosis Fugax]	Transient Vision Loss, Spontaneous
Amaurosis Fugax, Course Of Resolution Unspecified

Homocysteinemia

Hyperhomocysteinemia

Post-Thrombotic Syndrome

Postphlebitic Syndrome	Postthrombotic Syndrome
Postphlebetic Syndrome With Inflammation	Postphlebetic Syndrome With Ulcer
Postphlebetic Syndrome With Ulcer And Inflammation	Venous Stress Disorder

Hyperhomocysteinemia

Placental Abruption

Abruptio Placentae	Abruptio Placenta
Abortion, Threatened	Threatened Miscarriage
Haemorrhage Specified As Due To Threatened Abortion	Spontaneous Threatened Abortion

Quebec Platelet Disorder

Factor V Quebec	QPD
Bdplt5	Bleeding Disorder, Platelet-Type, 5
Platelet-Type Bleeding Disorder 5	Bleeding Disorder Platelet-Type 5
Platelet Disorder, Quebec

Hellp Syndrome

Hemolysis, Elevated Liver Enzymes, Lowered Platelets	Hemolysis, Elevated Liver Enzymes, Low Platelets In Pregnancy
Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome	Hellp - [Syndrome Of Haemolysis, Elevated Liver Enzymes And Low Platelet]
Haemolysis-Elevated Liver Enzymes-Low Platelet Count Syndrome

Hemorrhagic Disease

Hemorrhagic Disorders	Hemorrhagic Diathesis
Hemorrhagic Diseases	Bleeding Tendency
Acquired Coagulation Factor Inhibitor Disorder	Acquired Inhibitor Of Coagulation
Antithrombinaemia	Antithromboplastinogenaemia
Circulating Anticoagulant Disorder	Haemorrhagic Disorder Due To Antithrombinaemia
Haemorrhagic Disorder Due To Excess Administered Heparin	Antithromboplastinaemia
Haemorrhagic Disorder Due To Hyperheparinemia

Purpura Fulminans

Purpura Gangrenosa

Polycythemia

Erythrocythemia	Polycythemia Vera
Polycythaemia Due To High Altitude

Placenta Disease

Placenta Diseases	Placenta Disorder
Pregnancy Complications	Placenta Disorders

Mediastinitis

Homocystinuria

Cystathionine Beta Synthase Deficiency	Homocysteinemia
Cbs Deficiency	Cystathionine Synthase Deficiency
Cystathionine Beta-Synthase Deficiency Disease

Thrombophlebitis

Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities	Superficial Thrombophlebitis Of Leg
Thrombophlebitis Of A Superficial Leg Vein	Thrombophlebitis Of Superficial Veins Of Lower Extremity

Factor V And Factor Viii, Combined Deficiency Of, 2

Factor V And Factor Viii, Combined Deficiency Of	F5F8D2
Combined Deficiency Of Factor V And Factor Viii	F5f8d
Factor 5 And Factor Viii, Combined Deficiency Of, 2	Fv And Fviii Combined Deficiency
Factor V And Factor Viii Combined Deficiency 2	Mcfd2
Multiple Coagulation Factor Deficiency 2	Deficiency, Combined, Factor V And Factor Viii, Type 2

Polycythemia Vera

PV	Polycythemia Rubra Vera
Prv	Osler-Vaquez Disease
Chronic Erythremia	Polycythaemia Rubra Vera
Primary Polycythemia	Vaquez Disease
Polycythemia Vera, Somatic	Osler-Vaquez Syndrome
Proliferative Polycythaemia	Polycythemia Ruba Vera
Acquired Primary Erythrocytosis	Heilmeyer-Schoner Disease
Vaquez Osler Disease	Primary Polycythaemia

Acanthamoeba Keratitis

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Factor Xiii Deficiency

Hereditary Factor Xiii Deficiency Disease	Deficiency, Laki-Lorand Factor
Congenital Factor Xiii Deficiency	Fibrin Stabilizing Factor Deficiency
Deficiency, Factor Xiii	Factor Xiii Deficiency Disease
Deficiency Of Factor Xiii	Fibrin-Stabilizing Factor Deficiency
Factor Xiii Deficiency, Congenital

Retinal Artery Occlusion

Retina Artery Narrowing	Retinal Artery Spasm
Spasm Of Ophthalmic Artery	Retinal Spasm
Vasospasm Of Retina

Sneddon Syndrome

Livedo Reticularis And Cerebrovascular Accidents	SNDNS
Ehrmann-Sneddon Syndrome	Livedo Racemosa-Cerebrovascular Accident Syndrome
Livedo Reticularis-Cerebrovascular Accident Syndrome	Sneddon'S Syndrome
Idiopathic Livedo Reticularis With Systemic Involvement	Cerebro-Vascular Lesions And Livedo Reticularis
Livedo Racemosa And Cerebrovascular Accidents

Severe Pre-Eclampsia

Severe Preeclampsia	Antepartum Severe Pre-Eclampsia
Postpartum Severe Pre-Eclampsia	Severe Pre-Eclampsia, With Delivery
Severe Toxemia	Severe Pre-Eclampsia, Antepartum Condition Or Complication
Severe Pre-Eclampsia, Postpartum Condition Or Complication	Severe Puerperal Pre-Eclampsia
Severe Pre-Eclamptic Toxaemia	Severe Pet - [Pre-Eclamptic Toxaemia]

Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa	Foramen Ovale Patent
Ostium Secundum Atrial Septal Defect	Atrial Septal Defect, Ostium Secundum Type
Foramen Ovale, Patent	Defect, Patent Or Persistent, Ostium Secundum
Ostium Secundum Type Atrial Septal Defect	Persistent Ostium Secundum
Asd Ostium Secundum Type	Ostium Secundum Asd
Osasd	Asd, Ostium Secundum Type
Pfo - [Patent Foramen Ovale]	Open Foramen Ovale
Open Oval Foramen	Persistent Foramen Ovale
Secundum Atrial Septal Defect

Legg-Calve-Perthes Disease

Perthes Disease	LCPD
Coxa Plana	Legg-Perthes Disease
Juvenile Osteochondrosis Of Hip And Pelvis	Pseudocoxalgia
Legg-Calvé-Perthes Disease	Lcp
Calve - Perthes' Disease	Juvenile Osteochond-Hip/Pelvis
Juvenile Osteochondrosis Of Hip And/Or Pelvis	Legg-Calve-Perthes Symptom
Osteochondrosis Of Legg-Calve-Perthes	Perthe'S Disease
Legg-Calve-Perthes Syndrome	Osteochondritis Deformans
Calve-Perthes Disease	Aseptic Necrosis Of The Capital Femoral Epiphysis
Osteochondrosis Of The Capital Femoral Epiphysis	Legg-Calvé-Perthes Syndrome
Avascular Necrosis Of The Capital Femoral Epiphysis

Ovarian Hyperstimulation Syndrome

OHSS	Ovarian Hyperstimulation Syndrome, Familial Gestational Spontaneous
Secondary Meig'S Syndrome	Ohss - [Ovarian Hyperstimulation Syndrome]
Hyperstimulation Of Ovaries Nos	Hyperstimulation Of Ovaries Associated With Induced Ovulation

Dysfibrinogenemia, Congenital

Dysfibrinogenemia	Hypodysfibrinogenemia
Familial Dysfibrinogenemia	Familial Hypodysfibrinogenemia
Hypodysfibrinogenemia, Congenital	Dysfibrinogenemia, Familial
Congenital Dysfibrinogenemia	DYSFIBRIN

Adult Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome	Ards
Non-Cardiogenic Pulmonary Edema	Acute Lung Injury
Respiratory Distress Syndrome, Adult	Shock Lung
Acute Respiratory Distress	Respiratory Distress Syndrome
Adult Rds	Ali
Increased-Permeability Pulmonary Edema	Stiff Lung
Respiratory Distress Syndrome Adult

Sagittal Sinus Thrombosis

Thrombosis Of Superior Longitudinal Sinus	Thrombosis Of Superior Sagittal Sinus
Thrombosis Superior Sagittal Sinus

Intracranial Hypertension

Raised Intracranial Pressure

Scott Syndrome

SCTS	Bdplt7
Prothrombin Consumption Deficiency	Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X
Bleeding Disorder, Platelet-Type, 7	Prothrombin Conversion Defect, Familial
Prothrombin Consumption Inhibitor, Familial	Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X
Familial Prothrombin Consumption Inhibitor	Familial Prothrombin Conversion Defect
Platelet-Type Bleeding Disorder 7	Platelet Factor X Receptor Deficiency
Bleeding Disorder Platelet-Type 7	Prothrombin Consumption Inhibitor Familial
Prothrombin Conversion Defect Familial

Factor Xi Deficiency

Plasma Thromboplastin Antecedent Deficiency	Rosenthal Syndrome
Pta Deficiency	Hemophilia C
Rosenthal Factor Deficiency	F11 Deficiency
Congenital Factor Xi Deficiency	Hereditary Factor Xi Deficiency Disease
Haemophilia C	Factor Xi Deficiency, Autosomal Dominant
Rosenthal'S Disease	Factor 11 Deficiency
Factor Xi	Factor Xi Deficiency, Autosomal Recessive
Factor Xi Deficiency, Congenital	FA11D
Thromboplastin Antecedent Deficiency	Pta - [Plasma Thromboplastin Antecedent] Deficiency
Congenital Factor Xi Deficiency Disease	Rosenthal Disease

Venous Insufficiency

Peripheral Venous Insufficiency

Prothrombin Deficiency, Congenital

Dysprothrombinemia	Hypoprothrombinemia
Congenital Factor Ii Deficiency	Prothrombin Deficiency
Factor Ii Deficiency	Congenital Prothrombin Deficiency
FA2D	Hypoprothrombinemias
Inherited Factor Ii Deficiency	Hereditary Factor Ii Deficiency Disease

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Meningococcemia

Von Willebrand'S Disease

Von Willebrand Disease	Von Willebrand Disorder
Vascular Pseudohemophilia	Hereditary Von Willebrand Disease
Vwd	Vascular Hemophilia
Von Willebrand'S-Jurgens' Disease	Von Willebrand-Jrgens Disease
Von Willebrand Factor Deficiency	Von Willebrand Factor, Deficiency
Angiohemophilia	Von Willebrand'S Factor Deficiency
Von Willebrand Diseases	Factor Viii Deficiency With Vascular Defect
Vascular Haemophilia	Willebrand Jurgen Thrombopathy
Pseudohaemophilia	Minot-Von Willebrand-Jurgen Disease
Angiohaemophilia	Angiohaemophilia A
Angiohaemophilia B

Thrombasthenia

Cerebrovascular Disease

Cerebrovascular Disorder	Cerebrovascular Accident
Cerebrovascular Disorders	Cva
Stroke

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Varicose Veins

Varices	Varix
Venous Ectasia	Venous Varices
Varicosity

Afibrinogenemia, Congenital

Congenital Afibrinogenemia	Afibrinogenemia
Factor I Deficiency	Familial Afibrinogenemia
Hypofibrinogenemia, Congenital	Fibrinogen Deficiency
Afibrinogenemia Congenital	CAFBN
Congenital Hypofibrinogenemia	Hypofibrinogenemia
Complement Factor I Deficiency

Factor X Deficiency

Stuart-Prower Factor Deficiency	F10 Deficiency
Congenital Stuart Factor Deficiency	Factor X Deficiency, Congenital
Congenital Factor X Deficiency	Disease, Stuart-Prower
Stuart Factor Deficiency, Congenital	FA10D
Factor 10 Deficiency	Deficiency, Factor X
Hereditary Factor X Deficiency Disease	Deficiency Of Factor X
Stuart Deficiency Disease	Stuart Prower Deficiency
Stuart-Prower Disease

Gastroschisis

Laparoschisis	Congenital Fissure Of The Abdominal Cavity
Abdominal Wall Defect	Abdominal Hernia
Hernia, Abdominal	Omphalocele
Abnormality Of The Abdominal Wall	Congenital Omphalocele
Coeloschisis	Coelioschisis
Celoschisis	Congenital Para-Umbilical Hernia

Priapism

Mentulagra	Priapism, Familial Idiopathic
Familial Idiopathic Priapism	Pathologic Erection
Painful Erection

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1

Cadasil	Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy
Casil	Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy
Familial Vascular Leukoencephalopathy	CADASIL1
Cadasil 1	Hereditary Multi-Infarct Dementia
Cadasil Syndrome	Dementia, Hereditary Multiinfarct Type
Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1	Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1
Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy	Dementia, Hereditary Multi-Infarct Type
Hereditary Dementia, Multi-Infarct Type	Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1	Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant
Dementia Hereditary Multiinfarct Type	Dementia Hereditary Multi-Infarct Type
Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy

Cerebral Palsy

Infantile Cerebral Palsy	Mixed Cerebral Palsy
Palsy Cerebral	Palsy, Cerebral
Cerebral Palsy, Mixed

Beta-Thalassemia

Beta Thalassemia	Cooley'S Anemia
Mediterranean Anemia	Beta Thalassemia Intermedia
Erythroblastic Anemia	Thalassemia, Hispanic Gamma-Delta-Beta
Thalassemia Major	Thalassemia Minor
Beta-Plus-Thalassemia	Thalassemia, Beta
Beta Thalassemia Major	Beta Thalassemia Minor
Thalassemias, Beta-	Microcytemia, Beta Type
Thalassemia, Beta Type	B-THAL
Mediterranean Anaemia	Beta Thalassaemia Syndrome
Mediterranean Disease	Beta Thalassaemia Disease

Migraine With Aura

Classic Migraine	Migraine With Typical Aura
Migraine Accompagnée	Complicated Migraine
Classical Migraine	Acute Migraine With Aura

Blood Coagulation Disease

Blood Coagulation Disorders	Coagulation Protein Disease
Inherited Blood Coagulation Disease	Postpartum Coagulation Defect
Postpartum Coagulation Defect With Delivery	Coagulation Protein Disorders
Puerperal Coagulopathy

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Factor Viii Deficiency

Autosomal Hemophilia A	Hemophilia A
Autosomal Factor Viii Deficiency	Classic Hemophilia A
Congenital Factor Viii Disorder	Subhemophilia
Factor 8 Deficiency, Congenital	Factor Viii

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P0039	BIM-26226	Antagonist	99.94%	Phase 1

Pre-clinical Phase

Bioactive Molecules (41)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112698	CA-5f		99.14%	Unkown
HY-124421	5F-203	Inducer	99.04%	Unkown
HY-108277	Ginsenoside F5	Inducer	≥98.0%	Unkown
HY-W093272	Thalidomide-5,6-F	Inducer	99.84%	Unkown
HY-W010811	Fmoc-Phe(F5)-OH		99.08%	Unkown
HY-P5367	5-FAM-PMDM6		97.02%	Unkown
HY-10278	Razaxaban	Inhibitor	/	Unkown
HY-118847	Antifungal agent 86	Inhibitor	/	Unkown
HY-147698	ZLHQ-5f		/	Unkown
HY-D1410	DMTr-4'-F-5-Me-U-CED phosphoramidite		/	Unkown
HY-D1758	Fura-5F AM		/	Unkown
HY-D1779	Fura-5F pentapotassium		/	Unkown
HY-N8311	Goshonoside F5	Inhibitor	/	Unkown
HY-P4020	2F5 epitope		/	Unkown
HY-R01575	hsa-miR-518f-5p mimic		/	Unkown
HY-R01575A	hsa-miR-518f-5p agomir		/	Unkown
HY-R01604	hsa-miR-520f-5p mimic		/	Unkown
HY-R01604A	hsa-miR-520f-5p agomir		/	Unkown
HY-R01684	hsa-miR-548f-5p mimic		/	Unkown
HY-R01684A	hsa-miR-548f-5p agomir		/	Unkown
HY-R03052	mmu-miR-344f-5p mimic		/	Unkown
HY-R03052A	mmu-miR-344f-5p agomir		/	Unkown
HY-R03177	mmu-miR-466f-5p mimic		/	Unkown
HY-R03177A	mmu-miR-466f-5p agomir		/	Unkown
HY-R03468	mmu-miR-669f-5p mimic		/	Unkown
HY-R03468A	mmu-miR-669f-5p agomir		/	Unkown
HY-RI01575	hsa-miR-518f-5p inhibitor		/	Unkown
HY-RI01575A	hsa-miR-518f-5p antagomir		/	Unkown
HY-RI01604	hsa-miR-520f-5p inhibitor		/	Unkown
HY-RI01604A	hsa-miR-520f-5p antagomir		/	Unkown
HY-RI01684	hsa-miR-548f-5p inhibitor		/	Unkown
HY-RI01684A	hsa-miR-548f-5p antagomir		/	Unkown
HY-RI03052	mmu-miR-344f-5p inhibitor		/	Unkown
HY-RI03052A	mmu-miR-344f-5p antagomir		/	Unkown
HY-RI03177	mmu-miR-466f-5p inhibitor		/	Unkown
HY-RI03177A	mmu-miR-466f-5p antagomir		/	Unkown
HY-RI03468	mmu-miR-669f-5p inhibitor		/	Unkown
HY-RI03468A	mmu-miR-669f-5p antagomir		/	Unkown
HY-RS04114	E2F5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS04644	F5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09816	OR4F5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990255	Anti-Mouse CXCL9/MIG Antibody (MIG-2F5.5)		95.00%	Unkown
HY-P990221	Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	F5	VGNC	VGNC:28688
Macaca mulatta	F5	VGNC	VGNC:99921
Canis familiaris	F5	VGNC	VGNC:40551
Mus musculus	F5	MGD	MGI:88382
Felis catus	F5	VGNC	VGNC:62027
Rattus norvegicus	F5	RGD	RGD:1589758
Macaca fascicularis	F5	NCBI	NCBI:102141482
Leporidae	F5	NCBI
Others	F5	NCBI