ZLHQ-5f

Cat. No.: HY-147698: FAQs
Data Sheet Handling Instructions

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ZLHQ-5f is a dual CDK2 and Topo I inhibitor with an IC₅₀ of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggers apoptosis in HCT116 cells, and has a good safety profile.

For research use only. We do not sell to patients.

ZLHQ-5f Chemical Structure

CAS No. : 2851977-85-8

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

CDK2/CycA2

0.145 μM (IC₅₀)

Top1

In Vitro

ZLHQ-5f shows antiproliferative activity with GI₅₀ values of 0.949 ± 0.113, 0.821 ± 0.240, 1.124 ± 0.362, 1.945 ± 0.278 and 3.349 ± 0.149 μM against A549, HCT116, MCF-7, HepG2 and LO2 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

463.53

Formula

C₂₈H₂₅N₅O₂

CAS No.

2851977-85-8

SMILES

N[C@H]1CCN(C1)C2=C3OC4=C(C3=NC5=CC=C(C=C52)C6=CC(NC(C7CC7)=O)=NC=C6)C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Huang Y, et al. Discovery of novel benzofuro[3,2-b]quinoline derivatives as dual CDK2/Topo I inhibitors. Bioorg Chem. 2022 May 21;126:105870. [Content Brief]

ZLHQ-5f Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLHQ-5f2851977-85-8CDKTopoisomeraseApoptosisCyclin dependent kinaseHCT116anticancerA549MCF-7HepG2LO2Inhibitorinhibitorinhibit

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