Prdx2 - peroxiredoxin 2 Gene

Mus musculus

Also known as TR; PRP; TPx; TSA; TDX1; NkefB; PrxII; TPx-B; Tdpx1; Torin; Band-8

Gene ID: 21672 | Gene type: protein coding

About Prdx2

Summary

Predicted to enable thioredoxin peroxidase activity. Involved in positive regulation of blood coagulation and removal of superoxide radicals. Acts upstream of or within several processes, including negative regulation of NF-kappaB transcription factor activity; regulation of signal transduction; and respiratory burst involved in inflammatory response. Located in mitochondrion and myelin sheath. Is expressed in several structures, including alimentary system; central nervous system; limb; reproductive system; and sensory organ. Orthologous to human PRDX2 (peroxiredoxin 2). [provided by Alliance of Genome Resources, Apr 2022]

Prdx2 Products(2)

mRNA	Protein	Name
NM_001317385.1	NP_001304314.1	peroxiredoxin-2
NM_011563.6	NP_035693.3	peroxiredoxin-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17141802	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell homeostasis	IMP IMP: Inferred from mutant phenotype	15259009	MGI
acts upstream of or within T cell proliferation	IMP IMP: Inferred from mutant phenotype	15259009	MGI
acts upstream of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15259009	MGI
acts upstream of or within hydrogen peroxide catabolic process	IMP IMP: Inferred from mutant phenotype	15902258	MGI
acts upstream of or within hydrogen peroxide metabolic process	IMP IMP: Inferred from mutant phenotype	15259009	MGI
acts upstream of or within negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	17325201	MGI
acts upstream of or within negative regulation of T cell differentiation	IMP IMP: Inferred from mutant phenotype	16290204	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	15259009	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	9115640	MGI
acts upstream of or within negative regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17325201	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	17325201	MGI
involved in positive regulation of blood coagulation	IMP IMP: Inferred from mutant phenotype	20978343	MGI
acts upstream of or within regulation of hydrogen peroxide metabolic process	IMP IMP: Inferred from mutant phenotype	17325201	MGI
involved in removal of superoxide radicals	IMP IMP: Inferred from mutant phenotype	20978343	MGI
acts upstream of or within respiratory burst involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	17325201	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	17325201	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	15259009	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

peroxiredoxin-2

Calpromotin	Prx II-1
Trx dependent peroxide reductase 1	protector protein
thiol-specific antioxidant protein	thioredoxin peroxidase 1
thioredoxin reductase	thioredoxin-dependent peroxide reductase 1
thioredoxin-dependent peroxiredoxin 2

Recombinant Prdx2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73712	Peroxiredoxin-2/PRDX2 Protein, Mouse (sf9, His)	Q61171/NP_035693.3 (M1-N198)	≥95%

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1324	Oxiconazole nitrate		≥98.0%	Yes
HY-B1324A	Oxiconazole		/	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11075	PRDX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prdx2	NCBI	NCBI:7001

Name
Email *

	Sorry, but the email address you supplied was invalid.