PRDX2 - peroxiredoxin 2 Gene

Homo sapiens

Also known as PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a

Gene ID: 7001 | Gene type: protein coding

About PRDX2

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,796,823-12,801,800 (from NCBI)

This gene has 6 transcripts (splice variants), 136 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 201.9), heart (RPKM 194.1) and 25 other tissues.

Summary

This gene encodes a member of the peroxiredoxin family of antioxidant Enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the Antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in Cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

PRDX2 Products(1)

mRNA	Protein	Name
NM_005809.6	NP_005800.3	peroxiredoxin-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables antioxidant activity	IDA IDA: Inferred from direct assay	8144038	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17557078	GOA
enables thioredoxin peroxidase activity	IDA IDA: Inferred from direct assay	8144038	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	20978343	GOA
involved in defense response to tumor cell	IMP IMP: Inferred from mutant phenotype	30429596	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12943237	GOA
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	20978343	GOA
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	12943237	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDX2 Protein Structure

AhpC-TSA

1-cysPrx_C

0
100
198 a.a.

Protein Preferred Names

Protein Names

peroxiredoxin-2

epididymis secretory sperm binding protein Li 2a

Recombinant PRDX2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71464	Peroxiredoxin-2/PRDX2 Protein, Human (His)	P32119 (2A-198N)	≥95%
HY-P73374	Peroxiredoxin-2/PRDX2 Protein, Human (sf9, His)	P32119 (M1-N198)	≥95%

Related Diseases

Diseases

Alias

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Hereditary Spherocytosis

Congenital Spherocytic Hemolytic Anemia	Spherocytic Anemia
Congenital Spherocytosis	Spherocytosis, Type 1
Minkowski Chauffard Syndrome	Hs
Minkowski-Chauffard Disease	Minkowski-Chauffard Syndrome
Spherocytosis Hereditary	Spherocytosis, Hereditary
Anemia, Hereditary Spherocytic Hemolytic

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1324	Oxiconazole nitrate		≥98.0%	Yes
HY-B1324A	Oxiconazole		/	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11075	PRDX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRDX2	MGD	MGI:109486
Rattus norvegicus	PRDX2	RGD	RGD:3838
Bos taurus	PRDX2	VGNC	VGNC:33300
Felis catus	PRDX2	VGNC	VGNC:69037
Canis familiaris	PRDX2	VGNC	VGNC:44951
Others	PRDX2	NCBI

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