Fcho2 - FCH domain only 2 Gene

Mus musculus

Also known as 5832424M12Rik

Gene ID: 218503 | Gene type: protein coding

About Fcho2

Summary

Enables identical protein binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and phosphatidylserine binding activity. Involved in membrane invagination; protein localization to plasma membrane; and synaptic vesicle endocytosis. Located in clathrin-coated pit and clathrin-coated vesicle. Is expressed in endolymphatic appendage and head. Orthologous to human FCHO2 (FCH and mu domain containing endocytic adaptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fcho2 Products(1)

mRNA	Protein	Name
NM_172591.3	NP_766179.2	F-BAR domain only protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17540576	MGI
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	21762413	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	20448150	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	21762413	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20448150	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in membrane invagination	IDA IDA: Inferred from direct assay	20448150	MGI
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	20448150	MGI
involved in synaptic vesicle endocytosis	IGI IGI: Inferred from genetic interaction	20448150	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in clathrin-coated pit	IDA IDA: Inferred from direct assay	20448150	MGI
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	21762413	MGI
NOT colocalizes with clathrin-coated vesicle	IDA IDA: Inferred from direct assay	20448150	MGI
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	21762413	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	20448150	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

F-BAR domain only protein 2

FCH domain only protein 2

Fcho2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Fcho2	Q3UQN2	EPS15	Homo sapiens	P42566	Pull Down	20448150
Intra	Fcho2	Q3UQN2	EPS15	Homo sapiens	P42566	Confocal	20448150
Intra	Fcho2	Q3UQN2	ITSN1	Homo sapiens	Q15811	Confocal	20448150
Intra	Fcho2	Q3UQN2	ITSN1	Homo sapiens	Q15811	Pull Down	20448150
Intra	Fcho2	Q3UQN2	Fcho2	Mus musculus	Q3UQN2	EPR	17540576
Intra	Fcho2	Q3UQN2	Fcho2	Mus musculus	Q3UQN2	Chromatography	21762413
Intra	Fcho2	Q3UQN2	Fcho2	Mus musculus	Q3UQN2	Solution Sedimentation	17540576
Intra	Fcho2	Q3UQN2	FLG2	Homo sapiens	Q5D862	Pull Down	20448150
Intra	Fcho2	Q3UQN2	ITSN2	Homo sapiens	Q9NZM3	Pull Down	20448150
Intra	Fcho2	Q3UQN2	Fcho2	Mus musculus	Q3UQN2	Comigration in SDS	17540576
Intra	Fcho2	Q3UQN2	Fcho2	Mus musculus	Q3UQN2	GMS	17540576
Intra	Fcho2	Q3UQN2	ACTN4	Homo sapiens	O43707	Pull Down	20448150
Intra	Fcho2	Q3UQN2	MYH9	Homo sapiens	P35579	Pull Down	20448150
Intra	Fcho2	Q3UQN2	EPS15L1	Homo sapiens	Q9UBC2	Pull Down	20448150
Intra	Fcho2	Q3UQN2	DAB2	Homo sapiens	P98082	Pull Down	20448150
Intra	Fcho2	Q3UQN2	Dab2	Rattus norvegicus	O88797	Pull Down	20448150
Intra	Fcho2	Q3UQN2	Eps15l1	Rattus norvegicus	D3ZJR1	Pull Down	20448150
Intra	Fcho2	Q3UQN2	Dnm1	Rattus norvegicus	P21575	Pull Down	20448150
Cross	Fcho2	Q3UQN2	Eps15	Rattus norvegicus	A7BFV9	Pull Down	20448150
Intra	Fcho2	Q3UQN2	Itsn1	Rattus norvegicus	Q9WVE9	Pull Down	20448150

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04835	FCHO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fcho2	NCBI	NCBI:115548

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