2. Gene
  3. Tnc - tenascin C Gene

Tnc - tenascin C Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TN; Hxb; Ten; TN-C; cytotactin; tenascin-C; C130033P17Rik

Gene ID: 21923 | Gene type: protein coding

About Tnc

Summary

Predicted to enable fibronectin binding activity and syndecan binding activity. Acts upstream of or within several processes, including neuromuscular junction development; peripheral nervous system axon regeneration; and prostate gland development. Located in collagen-containing extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; brain; immune system; ovary; and skeletal system. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C). [provided by Alliance of Genome Resources, Apr 2022]

Tnc Products(5)

mRNA Protein Name
NM_001369211.1 NP_001356140.1 tenascin isoform 1 precursor
NM_001369212.1 NP_001356141.1 tenascin isoform 3 precursor
NM_001369213.1 NP_001356142.1 tenascin isoform 4
NM_001369214.1 NP_001356143.1 tenascin isoform 5 precursor
NM_011607.3 NP_035737.2 tenascin isoform 2 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within mesenchymal-epithelial cell signaling involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
18950615 MGI
involved in morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
18950615 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
9593587 MGI
involved in neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
9593587 MGI
acts upstream of or within peripheral nervous system axon regeneration IMP
IMP: Inferred from mutant phenotype
16262655 MGI
involved in peripheral nervous system axon regeneration IMP
IMP: Inferred from mutant phenotype
16262655 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
19690384 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
19690384 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
19690384 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: Inferred from mutant phenotype
18950615 MGI
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
10594729 MGI
Cellular Component GO Annotation Evidence Reference Source
located in basement membrane IDA
IDA: Inferred from direct assay
7687262 MGI
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
23658023 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
8856503 MGI
located in interstitial matrix IDA
IDA: Inferred from direct assay
11767049 MGI
is active in perisynaptic extracellular matrix EXP
EXP: Inferred from Experiment
16452087 MGI
is active in perisynaptic extracellular matrix IDA
IDA: Inferred from direct assay
16452087 MGI
part of tenascin complex IPI
IPI: Inferred from physical interaction
14709716 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tenascin

hexabrachion

Recombinant Tnc Proteins

Cat. No. Product Name Accession Purity
HY-P700002 Tenascin/Tnc protein, Mouse (His-Myc) Q80YX1 (G1884-N2099) ≥95%
HY-P700834 Tenascin/Tnc protein, Mouse (HEK293, His) Q80YX1-1 (G23-S621) ≥95%
HY-P700002A Tenascin/Tnc protein, Mouse (His-Myc, Solution) Q80YX1 (G1884-N2099) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14783 TNC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnc NCBI NCBI:3371