MED19 - mediator complex subunit 19 Gene

Homo sapiens

Also known as LCMR1; DT2P1G7; MED19AS

Gene ID: 219541 | Gene type: protein coding

About MED19

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,703,709-57,712,215 (from NCBI)

This gene has 5 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 7.0), brain (RPKM 5.0) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of Cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

MED19 Products(2)

mRNA	Protein	Name
NM_001317078.4	NP_001304007.2	mediator of RNA polymerase II transcription subunit 19 isoform 1
NM_153450.4	NP_703151.3	mediator of RNA polymerase II transcription subunit 19 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14576168	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of core mediator complex	IPI IPI: Inferred from physical interaction	24882805	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24882805	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED19 Protein Structure

Med19

0
100
194 a.a.

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 19

lung cancer metastasis-related protein 1

MED19 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	14576168
Intra	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	14638676
Intra	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	33961781
Intra	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	15175163
Intra	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	21729782
Intra	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	24882805
Intra	MED19	A0JLT2	MED29	Homo sapiens	Q9NX70	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lipodystrophy, Familial Partial, Type 5

FPLD5	Cidec-Related Familial Partial Lipodystrophy
Familial Partial Lipodystrophy Type 5	Cidec-Related Fpld
Familial Partial Lipodystrophy Associated With Cidec Mutations	Lipodystrophy, Familial Partial, Associated With Cidec Mutations
Lipodystrophy, Familial Partial, 5

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08290	MED19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MED19	VGNC	VGNC:31356
Mus musculus	MED19	MGD	MGI:1914234
Macaca mulatta	MED19	VGNC	VGNC:74615
Rattus norvegicus	MED19	RGD	RGD:1311926
Felis catus	MED19	VGNC	VGNC:103134
Canis familiaris	MED19	VGNC	VGNC:43128

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