Top2a - topoisomerase (DNA) II alpha Gene

Mus musculus

Also known as Top-2

Gene ID: 21973 | Gene type: protein coding

About Top2a

Chromosome 11: 98,883,769-98,915,015 reverse strand.GRCm39:CM001004.3

This gene has 7 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 29 phenotypes. Biased expression in CNS E11.5 (RPKM 79.9), liver E14 (RPKM 47.8) and 1 other tissues.

Summary

Enables DNA Topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in female meiotic nuclear division and regulation of circadian rhythm. Acts upstream of or within several processes, including DNA conformation change; embryonic cleavage; and hematopoietic progenitor cell differentiation. Located in chromosome, centromeric region; condensed chromosome; and nucleolus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA Topoisomerase II alpha). [provided by Alliance of Genome Resources, Apr 2022]

Top2a Products(1)

mRNA	Protein	Name
NM_011623.2	NP_035753.2	DNA topoisomerase 2-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA IDA: Inferred from direct assay	1331984	MGI
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IGI IGI: Inferred from genetic interaction	1331984	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23698369	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within DNA topological change	IDA IDA: Inferred from direct assay	1331984	MGI
acts upstream of or within chromosome condensation	IMP IMP: Inferred from mutant phenotype	11835580	MGI
acts upstream of or within chromosome segregation	IDA IDA: Inferred from direct assay	7842491	MGI
acts upstream of or within chromosome segregation	IMP IMP: Inferred from mutant phenotype	11835580	MGI
acts upstream of or within embryonic cleavage	IMP IMP: Inferred from mutant phenotype	11835580	MGI
involved in female meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	25961503	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	24029230	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	1683482	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	24321095	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	26919979	MGI
located in condensed chromosome	IDA IDA: Inferred from direct assay	11835579	MGI
located in condensed chromosome	IMP IMP: Inferred from mutant phenotype	21795393	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	9094096	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	11835579	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	25961503	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9224616	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Top2a Protein Structure

PTZ00108

DTHCT

0
300
600
900
1200
1528 a.a.

Protein Preferred Names

Protein Names

DNA topoisomerase 2-alpha

DNA Topoisomerase II alpha

DNA topoisomerase II, alpha isozyme

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111630	PluriSIn #2	Inhibitor	≥98.0%	Unkown
HY-RS14894	TOP2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-164143	T638	Inhibitor	/	Unkown
HY-RS14895	Top2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14896	Top2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Top2a	NCBI	NCBI:7153

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