2. Gene
  3. Top2a - topoisomerase (DNA) II alpha Gene

Top2a - topoisomerase (DNA) II alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Top-2

Gene ID: 21973 | Gene type: protein coding

About Top2a

Chromosome 11: 98,883,769-98,915,015 reverse strand.GRCm39:CM001004.3

This gene has 7 transcripts (splice variants), 205 orthologues, 1 paralogue and is associated with 29 phenotypes. Biased expression in CNS E11.5 (RPKM 79.9), liver E14 (RPKM 47.8) and 1 other tissues.

Summary

Enables DNA Topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Involved in female meiotic nuclear division and regulation of circadian rhythm. Acts upstream of or within several processes, including DNA conformation change; embryonic cleavage; and hematopoietic progenitor cell differentiation. Located in chromosome, centromeric region; condensed chromosome; and nucleolus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TOP2A (DNA Topoisomerase II alpha). [provided by Alliance of Genome Resources, Apr 2022]

Top2a Products(1)

mRNA Protein Name
NM_011623.2 NP_035753.2 DNA topoisomerase 2-alpha

Top2a Protein Structure

PTZ00108

PTZ00108: PTZ00108 (23 - 1440)

DTHCT

DTHCT: pfam08070 (1430 - 1517)

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  • 1528 a.a.
Protein Preferred Names Protein Names

DNA topoisomerase 2-alpha

DNA Topoisomerase II alpha

DNA topoisomerase II, alpha isozyme

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111630 PluriSIn #2 Inhibitor ≥98.0% Unkown
HY-164143 T638 Inhibitor / Unkown
HY-RS14894 TOP2A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14895 Top2a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14896 Top2a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Top2a NCBI NCBI:7153