STOX1 - storkhead box 1 Gene

Homo sapiens

Also known as C10orf24

Gene ID: 219736 | Gene type: protein coding

About STOX1

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:68,827,531-68,895,432 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in brain (RPKM 2.8), fat (RPKM 2.4) and 21 other tissues.

Summary

The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

STOX1 Products(4)

mRNA	Protein	Name
NM_001130159.3	NP_001123631.1	storkhead-box protein 1 isoform b
NM_001130160.3	NP_001123632.1	storkhead-box protein 1 isoform c
NM_001130161.4	NP_001123633.1	storkhead-box protein 1 isoform a
NM_152709.5	NP_689922.3	storkhead-box protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22253775	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to nitrosative stress	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22253775	GOA
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22253775	GOA
involved in positive regulation of G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	22253775	GOA
involved in positive regulation of cyclin-dependent protein kinase activity	IMP IMP: Inferred from mutant phenotype	22253775	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22253775	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	22995177	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IMP IMP: Inferred from mutant phenotype	22995177	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in regulation of mitochondrial DNA metabolic process	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in regulation of mitochondrion organization	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in regulation of response to oxidative stress	IMP IMP: Inferred from mutant phenotype	24738702	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24738702	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	22253775	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22253775	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22253775	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STOX1 Protein Structure

Stork_head

0
200
400
600
800
989 a.a.

Protein Preferred Names

Protein Names

storkhead-box protein 1

winged-helix domain-containing protein

STOX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STOX1	Q6ZVD7	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	STOX1	Q6ZVD7	ADARB1	Homo sapiens	P78563-4	Y2H Array	32296183
Intra	STOX1	Q6ZVD7	ADARB1	Homo sapiens	P78563-4	Y2H Prey Pooling	32296183
Intra	STOX1	Q6ZVD7	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	31515488
Intra	STOX1	Q6ZVD7	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
Intra	STOX1	Q6ZVD7	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Preeclampsia/Eclampsia 4

PEE4	Pre-Eclampsia/Eclampsia 4
Gestational Proteinuric Hypertension	Preeclampsia/Eclampsia, Type 4
Preeclampsia Eclampsia 4

Eclampsia

Eclampsia In Puerperium	Postpartum Eclampsia
Eclampsia, Postpartum	Puerperal Eclampsia

Pre-Eclampsia

Preeclampsia	Gestational Hypertension
Hypertension Induced By Pregnancy	Pre-Eclamptic Toxaemia
Pregnancy Associated Hypertension	Proteinuric Hypertension Of Pregnancy
Hypertension, Pregnancy-Induced, Susceptibility To	Preeclampsia/Eclampsia
Pregnancy Toxemia	Toxaemia Of Pregnancy
Gestational Proteinuric Hypertension	Pregnancy-Induced Hypertension
Toxemia Of Pregnancy	Preeclampsia, Susceptibility To
Transient Hypertension Of Pregnancy	Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria
Gestational Hypertension Nos	Mild Proteinuric Hypertension Of Pregnancy
Pih - [Pregnancy-Induced Hypertension]	Pregnancy-Induced Hypertension Nos
Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria	Pe - [Pre-Eclampsia]
Pre-Eclampsia Nos	Pre-Eclamptic Nos
Pregnancy Pre-Eclampsia	Puerperal Pre-Eclampsia
Pre-Eclampsia Toxaemia	Toxaemia In Pregnancy
Pet - [Pre-Eclamptic Toxaemia]	Maternal Toxaemia

Severe Pre-Eclampsia

Severe Preeclampsia	Antepartum Severe Pre-Eclampsia
Postpartum Severe Pre-Eclampsia	Severe Pre-Eclampsia, With Delivery
Severe Toxemia	Severe Pre-Eclampsia, Antepartum Condition Or Complication
Severe Pre-Eclampsia, Postpartum Condition Or Complication	Severe Puerperal Pre-Eclampsia
Severe Pre-Eclamptic Toxaemia	Severe Pet - [Pre-Eclamptic Toxaemia]

Patau Syndrome

Trisomy 13	Complete Trisomy 13 Syndrome
Trisomy 13 Syndrome	D1 Trisomy
Patau'S Syndrome	Complete Trisomy 13
Chromosome 13, Trisomy 13 Complete	D Trisomy Syndrome
Bartholin-Patau Syndrome	Chromosome 13 Duplication
D1 Trisomy Syndrome	D>1< Trisomy Syndrome
Patau	Chromosome 13 Trisomy
Abnormal Autosomes 13

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13954	STOX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	STOX1	VGNC	VGNC:35414
Canis familiaris	STOX1	VGNC	VGNC:49791
Macaca mulatta	STOX1	VGNC	VGNC:78197
Mus musculus	STOX1	MGD	MGI:2684909
Rattus norvegicus	STOX1	RGD	RGD:1310622

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