2. Gene
  3. Trp73 - transformation related protein 73 Gene

Trp73 - transformation related protein 73 Gene

  • Gene
  • Protein
Mus musculus

Also known as p73; Tp73; TAp73; deltaNp73

Gene ID: 22062 | Gene type: protein coding

About Trp73

Summary

This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and Apoptosis. The family members can interact with each Other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]

Trp73 Products(3)

mRNA Protein Name
NM_001126330.1 NP_001119802.1 tumor protein p73 isoform b
NM_001126331.1 NP_001119803.1 tumor protein p73 isoform c
NM_011642.4 NP_035772.3 tumor protein p73 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
16363065 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16044147 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11278685 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA damage response IMP
IMP: Inferred from mutant phenotype
16044147 MGI
acts upstream of or within cerebrospinal fluid secretion IMP
IMP: Inferred from mutant phenotype
10716451 MGI
acts upstream of or within digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
10716451 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
15525772 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
10716451 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
10716451 MGI
acts upstream of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
IGI: Inferred from genetic interaction
15983387 MGI
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
12427836 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
10894779 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
12427836 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16044147 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16044147 MGI
acts upstream of or within positive regulation of cell size IMP
IMP: Inferred from mutant phenotype
12427836 MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
IGI: Inferred from genetic interaction
15983387 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
10716451 MGI
acts upstream of or within regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
15483136 MGI
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
14555234 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor protein p73

Trp73 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Tp73 Q9JJP2 Yap1 Mus musculus P46938
Anti Bait CoIP
11278685
Cross: Cross-species interaction Intra: Intraspecies interaction