ALKBH3 - alkB homolog 3, alpha-ketoglutarate dependent dioxygenase Gene

Homo sapiens

Also known as ABH3; PCA1; DEPC1; hABH3; DEPC-1

Gene ID: 221120 | Gene type: protein coding

About ALKBH3

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:43,880,831-43,920,274 (from NCBI)

This gene has 12 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in testis (RPKM 6.9), prostate (RPKM 6.8) and 25 other tissues.

Summary

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

ALKBH3 Products(1)

mRNA	Protein	Name
NM_139178.4	NP_631917.1	alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables broad specificity oxidative DNA demethylase activity	IDA IDA: Inferred from direct assay	12486230	GOA
enables broad specificity oxidative DNA demethylase activity	IMP IMP: Inferred from mutant phenotype	22055184	GOA
enables ferrous iron binding	IDA IDA: Inferred from direct assay	16858410	GOA
enables mRNA N1-methyladenosine dioxygenase activity	IDA IDA: Inferred from direct assay	26863196	GOA
enables oxidative RNA demethylase activity	IDA IDA: Inferred from direct assay	16174769	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22055184	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA alkylation repair	IDA IDA: Inferred from direct assay	20714506	GOA
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	22055184	GOA
involved in negative regulation of cytoplasmic translation	IDA IDA: Inferred from direct assay	26863196	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH3 Protein Structure

2OG-FeII_Oxy_2

0
100
200
286 a.a.

Protein Preferred Names

Protein Names

alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

alkB homolog 3, alpha-ketoglutaratedependent dioxygenase

ALKBH3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ALKBH3	Q96Q83	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
Intra	ALKBH3	Q96Q83	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	25416956
Intra	ALKBH3	Q96Q83	GLRX3	Homo sapiens	O76003	Validated Y2H	25416956
Intra	ALKBH3	Q96Q83	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	ALKBH3	Q96Q83	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	25416956
Intra	ALKBH3	Q96Q83	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	25416956
Intra	ALKBH3	Q96Q83	IKZF1	Homo sapiens	Q13422	Y2H Array	25416956
Intra	ALKBH3	Q96Q83	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	ALKBH3	Q96Q83	AK8	Homo sapiens	Q96MA6	Validated Y2H	25416956
Intra	ALKBH3	Q96Q83	AK8	Homo sapiens	Q96MA6	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100199	HUHS015	Inhibitor	99.85%	Unkown
HY-RS00605	ALKBH3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ALKBH3	VGNC	VGNC:37804
Macaca mulatta	ALKBH3	VGNC	VGNC:69736
Felis catus	ALKBH3	VGNC	VGNC:59751
Mus musculus	ALKBH3	MGD	MGI:1916363
Bos taurus	ALKBH3	VGNC	VGNC:25834
Rattus norvegicus	ALKBH3	RGD	RGD:1359731

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