AK8 - adenylate kinase 8 Gene

Homo sapiens

Also known as AK 8; DDX31; C9orf98

Gene ID: 158067 | Gene type: protein coding

About AK8

Cytogenetic location: 9q34.13 Genomic coordinates (GRCh38): 9:132,725,578-132,879,046 (from NCBI)

This gene has 5 transcripts (splice variants), 107 orthologues and 9 paralogues. Biased expression in testis (RPKM 3.3), thyroid (RPKM 0.7) and 8 other tissues.

Summary

Enables AMP binding activity and nucleobase-containing compound kinase activity. Involved in nucleoside diphosphate phosphorylation and nucleoside triphosphate biosynthetic process. Located in 9+2 motile cilium. [provided by Alliance of Genome Resources, Apr 2022]

AK8 Products(7)

mRNA	Protein	Name
NM_001317958.2	NP_001304887.1	adenylate kinase 8 isoform 2
NM_001317959.2	NP_001304888.1	adenylate kinase 8 isoform 3
NM_001371771.1	NP_001358700.1	adenylate kinase 8 isoform 4
NM_001371772.1	NP_001358701.1	adenylate kinase 8 isoform 5
NM_001371773.1	NP_001358702.1	adenylate kinase 8 isoform 2
NM_001371774.1	NP_001358703.1	adenylate kinase 8 isoform 2
NM_152572.3	NP_689785.1	adenylate kinase 8 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables (d)CMP kinase activity	IDA IDA: Inferred from direct assay	21080915	GOA
enables AMP binding	IDA IDA: Inferred from direct assay	33139725	GOA
enables adenylate kinase activity	IDA IDA: Inferred from direct assay	21080915	GOA
enables nucleoside diphosphate kinase activity	IDA IDA: Inferred from direct assay	23416111	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in 9+2 motile cilium	IDA IDA: Inferred from direct assay	33139725	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AK8 Protein Structure

ADK

0
100
200
300
400
479 a.a.

Protein Preferred Names

Protein Names

adenylate kinase 8

ATP-AMP transphosphorylase 8

AK8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AK8	Q96MA6	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
Intra	AK8	Q96MA6	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
Intra	AK8	Q96MA6	MAP3K7CL	Homo sapiens	P57077-4	Y2H Prey Pooling	25416956
Intra	AK8	Q96MA6	MAP3K7CL	Homo sapiens	P57077-4	Validated Y2H	25416956
Intra	AK8	Q96MA6	MAP3K7CL	Homo sapiens	P57077-4	Y2H Array	25416956
Intra	AK8	Q96MA6	HAUS1	Homo sapiens	Q96CS2	Y2H Array	25416956
Intra	AK8	Q96MA6	ERN1	Homo sapiens	O75460-2	Validated Y2H	32814053
Intra	AK8	Q96MA6	ERN1	Homo sapiens	O75460-2	Y2H Array	32814053
Intra	AK8	Q96MA6	ERN1	Homo sapiens	O75460-2	Y2H Pooling	32814053
Intra	AK8	Q96MA6	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	25416956
Intra	AK8	Q96MA6	SMG9	Homo sapiens	Q9H0W8	Validated Y2H	32296183
Intra	AK8	Q96MA6	MCM7	Homo sapiens	P33993	Validated Y2H	25416956
Intra	AK8	Q96MA6	MCM7	Homo sapiens	P33993	Y2H Prey Pooling	25416956
Intra	AK8	Q96MA6	RBM39	Homo sapiens	Q14498	Y2H Array	25416956
Intra	AK8	Q96MA6	RBM39	Homo sapiens	Q14498	Y2H Prey Pooling	25416956
Intra	AK8	Q96MA6	RBM39	Homo sapiens	Q14498-3	Y2H Array	25416956
Intra	AK8	Q96MA6	RBM39	Homo sapiens	Q14498-3	Y2H Prey Pooling	25416956
Intra	AK8	Q96MA6	ALKBH3	Homo sapiens	Q96Q83	Y2H Prey Pooling	25416956
Intra	AK8	Q96MA6	UBE2Z	Homo sapiens	Q9H832	Validated Y2H	25416956
Intra	AK8	Q96MA6	UBE2Z	Homo sapiens	Q9H832	Y2H Array	25416956
Intra	AK8	Q96MA6	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183
Intra	AK8	Q96MA6	SYT17	Homo sapiens	Q9BSW7	Validated Y2H	32296183
Intra	AK8	Q96MA6	MID1IP1	Homo sapiens	Q9NPA3	Validated Y2H	25416956
Intra	AK8	Q96MA6	MID1IP1	Homo sapiens	Q9NPA3	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Reticular Dysgenesis

Severe Combined Immunodeficiency With Leukopenia	De Vaal Disease
Congenital Aleukia	Aleukocytosis
Hematopoietic Hypoplasia, Generalized	Reticular Dysgenesia
Devaal Disease	Rd
Ak2 Deficiency	Congenital Aleukocytosis
Generalized Hematopoietic Hypoplasia	Scid With Leukopenia
RDYS

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00510	AK8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AK8	VGNC	VGNC:59709
Canis familiaris	AK8	VGNC	VGNC:37749
Mus musculus	AK8	MGD	MGI:1916120
Macaca mulatta	AK8	VGNC	VGNC:69710
Bos taurus	AK8	VGNC	VGNC:25777
Rattus norvegicus	AK8	RGD	RGD:1303144

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