2. Gene
  3. ADGRF5 - adhesion G protein-coupled receptor F5 Gene

ADGRF5 - adhesion G protein-coupled receptor F5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GPR116; KPG_001

Gene ID: 221395 | Gene type: protein coding

About ADGRF5

This gene has 4 transcripts (splice variants), 324 orthologues and 42 paralogues. Broad expression in lung (RPKM 71.0), fat (RPKM 49.8) and 16 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to act upstream of or within several processes, including glomerular filtration; pharyngeal arch artery morphogenesis; and surfactant homeostasis. Located in cell surface and cytoplasmic vesicle. [provided by Alliance of Genome Resources, Apr 2022]

ADGRF5 Products(2)

mRNA Protein Name
NM_001098518.2 NP_001091988.1 adhesion G protein-coupled receptor F5 precursor
NM_015234.5 NP_056049.4 adhesion G protein-coupled receptor F5 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
23684610 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
23684610 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRF5 Protein Structure

SEA

SEA: SEA domain (169 - 264)

I-set

I-set: Immunoglobulin I-set domain (285 - 352)

Ig_2

Ig_2: Immunoglobulin domain (474 - 562)

GPS

GPS: GPCR proteolysis site, GPS, motif (951 - 997)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (1012 - 1262)

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  • 1346 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor F5

G-protein coupled receptor 116

ADGRF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ADGRF5 Q8IZF2 CABP2 Homo sapiens Q9NPB3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Soft Tissue Chondroma

Extraskeletal Chondroma
Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria

BFPP

Cerebellar Ataxia With Neuronal Migration Defect
Retinitis Pigmentosa 19

RP19

Retinitis Pigmentosa-19

Retinitis Pigmentosa, Type 19
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00353 ADGRF5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ADGRF5 MGD MGI:2182928
Felis catus ADGRF5 VGNC VGNC:59634
Macaca mulatta ADGRF5 VGNC VGNC:69471
Canis familiaris ADGRF5 VGNC VGNC:37642
Rattus norvegicus ADGRF5 RGD RGD:621679
Bos taurus ADGRF5 VGNC VGNC:25665