CABP2 - calcium binding protein 2 Gene

Homo sapiens

Also known as DFNB93

Gene ID: 51475 | Gene type: protein coding

About CABP2

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:67,518,912-67,523,446 (from NCBI)

This gene has 4 transcripts (splice variants), 254 orthologues, 20 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene belongs to a subfamily of calcium binding proteins that share similarity to Calmodulin. Like Calmodulin, these family members can likely stimulate calmodulin-dependent kinase II and the protein phosphatase Calcineurin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

CABP2 Products(2)

mRNA	Protein	Name
NM_001318496.2	NP_001305425.1	calcium-binding protein 2 isoform 3
NM_016366.3	NP_057450.2	calcium-binding protein 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19338761	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19338761	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CABP2 Protein Structure

EF-hand_1

EF-hand_7

0
100
200
220 a.a.

Protein Preferred Names

Protein Names

calcium-binding protein 2

CABP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CABP2	Q9NPB3	TEKT5	Homo sapiens	Q96M29	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	TEKT5	Homo sapiens	Q96M29	Y2H Array	32296183
Intra	CABP2	Q9NPB3	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	CABP2	Q9NPB3	RD3	Homo sapiens	Q7Z3Z2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	RD3	Homo sapiens	Q7Z3Z2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	SPMIP6	Homo sapiens	Q8NCR6	Y2H Array	32296183
Intra	CABP2	Q9NPB3	SPMIP6	Homo sapiens	Q8NCR6	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	CARD9	Homo sapiens	Q9H257-2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	MXRA8	Homo sapiens	Q9BRK3	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	MXRA8	Homo sapiens	Q9BRK3	Y2H Array	32296183
Intra	CABP2	Q9NPB3	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	SPATC1L	Homo sapiens	Q9H0A9-2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	SPATC1L	Homo sapiens	Q9H0A9-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ZNF140	Homo sapiens	P52738	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ZNF140	Homo sapiens	P52738	Y2H Array	32296183
Intra	CABP2	Q9NPB3	VXN	Homo sapiens	Q8TAG6	Y2H Array	32296183
Intra	CABP2	Q9NPB3	VXN	Homo sapiens	Q8TAG6	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	CIMIP1	Homo sapiens	Q9H1P6	Y2H Array	32296183
Intra	CABP2	Q9NPB3	CIMIP1	Homo sapiens	Q9H1P6	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	CABP2	Q9NPB3	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	UNKL	Homo sapiens	Q9H9P5-5	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	UNKL	Homo sapiens	Q9H9P5-5	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NOP10	Homo sapiens	Q9NPE3	Validated Y2H	32296183
Intra	CABP2	Q9NPB3	NOP10	Homo sapiens	Q9NPE3	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NOP10	Homo sapiens	Q9NPE3	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	HOXD12	Homo sapiens	P35452-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ANKRD29	Homo sapiens	Q8N6D5	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ANKRD29	Homo sapiens	Q8N6D5	Y2H Array	32296183
Intra	CABP2	Q9NPB3	TRIM35	Homo sapiens	Q9UPQ4-2	Validated Y2H	32296183
Intra	CABP2	Q9NPB3	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	TRIM35	Homo sapiens	Q9UPQ4-2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	DPEP2NB	Homo sapiens	A0A0U1RQF7	Y2H Array	32296183
Intra	CABP2	Q9NPB3	DPEP2NB	Homo sapiens	A0A0U1RQF7	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	NDUFAF3	Homo sapiens	Q9BU61	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NDUFAF3	Homo sapiens	Q9BU61	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	EFHC2	Homo sapiens	Q5JST6	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	EFHC2	Homo sapiens	Q5JST6	Y2H Array	32296183
Intra	CABP2	Q9NPB3	COA6	Homo sapiens	Q5JTJ3	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	COA6	Homo sapiens	Q5JTJ3	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NUDT16L1	Homo sapiens	Q9BRJ7	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	NUDT16L1	Homo sapiens	Q9BRJ7	Y2H Array	32296183
Intra	CABP2	Q9NPB3	ZNF785	Homo sapiens	A8K8V0	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ZNF785	Homo sapiens	A8K8V0	Y2H Array	32296183
Intra	CABP2	Q9NPB3	THAP6	Homo sapiens	Q8TBB0	Y2H Array	32296183
Intra	CABP2	Q9NPB3	THAP6	Homo sapiens	Q8TBB0	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	CABP2	Q9NPB3	C22orf39	Homo sapiens	Q6P5X5	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	C22orf39	Homo sapiens	Q6P5X5	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NME4	Homo sapiens	O00746	Y2H Array	32296183
Intra	CABP2	Q9NPB3	NME4	Homo sapiens	O00746	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	TNNI1	Homo sapiens	P19237	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	TNNI1	Homo sapiens	P19237	Y2H Array	32296183
Intra	CABP2	Q9NPB3	ADGRF5	Homo sapiens	Q8IZF2	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ADGRF5	Homo sapiens	Q8IZF2	Y2H Array	32296183
Intra	CABP2	Q9NPB3	ZNF57	Homo sapiens	Q68EA5	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	ZNF57	Homo sapiens	Q68EA5	Y2H Array	32296183
Intra	CABP2	Q9NPB3	AVPI1	Homo sapiens	Q5T686	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	AVPI1	Homo sapiens	Q5T686	Y2H Array	32296183
Intra	CABP2	Q9NPB3	SNAI2	Homo sapiens	O43623	Y2H Prey Pooling	32296183
Intra	CABP2	Q9NPB3	SNAI2	Homo sapiens	O43623	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Recessive 93

DFNB93	Autosomal Recessive Nonsyndromic Deafness 93
Autosomal Recessive Deafness 93	Deafness, Autosomal Recessive, 93
Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 93	Deafness, Autosomal Recessive, Type 93

Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb

Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb	Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb
Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb

Deafness, Autosomal Recessive

Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic

Deafness, Autosomal Dominant 2b

DFNA2B	Autosomal Dominant Nonsyndromic Deafness 2b
Autosomal Dominant Deafness 2b	Deafness, Autosomal Dominant, 2b
Deafness, Autosomal Dominant, Type 2b

Deafness, Autosomal Recessive 35

DFNB35	Autosomal Recessive Nonsyndromic Deafness 35
Autosomal Recessive Deafness 35	Deafness, Autosomal Recessive, 35
Deafness, Autosomal Recessive, Type 35

Deafness, Autosomal Recessive 6

DFNB6	Neurosensory Nonsyndromic Recessive Deafness 6
Nsrd6	Autosomal Recessive Nonsyndromic Deafness 6
Autosomal Recessive Deafness 6	Deafness, Autosomal Recessive, 6
Deafness Neurosensory Autosomal Recessive 6	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 6
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 6	Deafness, Autosomal Recessive, Type 6

Deafness, Autosomal Recessive 67

DFNB67	Autosomal Recessive Nonsyndromic Deafness 67
Autosomal Recessive Deafness 67	Deafness, Autosomal Recessive, 67
Deafness, Autosomal Recessive, Type 67

Charcot-Marie-Tooth Disease X-Linked Recessive 4

Cmt4x	Cmtx4
Cowchock Syndrome	X-Linked Charcot-Marie-Tooth Disease Type 4
Axonal Motor Sensory Neuropathy With Deafness And Mental Retardation	Charcot-Marie-Tooth Disease With Deafness And Mental Retardation
Nadmr	Namsd

Melkersson-Rosenthal Syndrome

Melkersson Syndrome	Mros
Mrs	Cheilitis Granulomatosa Of Mescher-Melkersson-Rosenthal
Melkersson'S Syndrome	Cheilitis Granulomatosa
Granulomatous Cheilitis

Erythrokeratodermia Variabilis Et Progressiva 1

Erythrokeratodermia Variabilis	Erythrokeratodermia Variabilis Et Progressiva
Greither Disease	Ekv
Ekvp	PSEK
Erythrokeratodermia Variabilis With Erythema Gyratum Repens	Keratosis Palmoplantaris Transgrediens Et Progrediens
Transgrediens Et Progrediens Palmoplantar Keratoderma	EKVP1
Erythrokeratodermia, Progressive Symmetric	Erythrokeratodermia Figurata, Congenital Familial, In Plaques
Keratoderma Palmoplantaris Transgrediens	Keratosis Extremitatum Hereditaria Progrediens
Erythrokeratodermia Variabilis, Mendes Da Costa Type	Progressive Symmetric Erythrokeratodermia
Erythrokeratodermia Figurata Variabilis	Greither'S Disease
Ekv-P	Erythrokeratodermia Variabilis Of Mendes Da Costa
Progressive Symmetrical Erythrokeratoderma Of Gottron	Progressive Diffuse Ppk
Progressive Diffuse Palmoplantar Keratoderma	Transgrediens Et Progrediens Ppk
Darier-Gottron Disease	Erythrokeratodermia Progressiva Symmetrica
Progressive Symmetric Erythrokeratodermia, Gottron Type	Congenital Familial Erythrokeratodermia Figurata In Plaques
Erythrokeratodermia Progressive Symmetric	Erythrokeratodermia Variabilis Mendes Da Costa Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01784	CABP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CABP2	VGNC	VGNC:60286
Mus musculus	CABP2	MGD	MGI:1352749
Macaca mulatta	CABP2	VGNC	VGNC:70496
Rattus norvegicus	CABP2	RGD	RGD:1563670
Canis familiaris	CABP2	VGNC	VGNC:38624
Bos taurus	CABP2	VGNC	VGNC:26665

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