FCGRT - Fc gamma receptor and transporter Gene

Homo sapiens

Also known as FCRN; FcgammaRn; alpha-chain

Gene ID: 2217 | Gene type: protein coding

About FCGRT

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,512,661-49,526,428 (from NCBI)

This gene has 18 transcripts (splice variants), 352 orthologues and 22 paralogues. Ubiquitous expression in duodenum (RPKM 99.0), small intestine (RPKM 98.5) and 25 other tissues.

Summary

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G Antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

FCGRT Products(6)

mRNA	Protein	Name
NM_001136019.3	NP_001129491.1	IgG receptor FcRn large subunit p51 isoform 1 precursor
NM_001411064.1	NP_001397993.1	IgG receptor FcRn large subunit p51 isoform 2 precursor
NM_004107.5	NP_004098.1	IgG receptor FcRn large subunit p51 isoform 1 precursor
NM_001136019.3	NP_001129491.1	IgG receptor FcRn large subunit p51 isoform 1 precursor
NM_001411064.1	NP_001397993.1	IgG receptor FcRn large subunit p51 isoform 2 precursor
NM_004107.5	NP_004098.1	IgG receptor FcRn large subunit p51 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables IgG binding	IDA IDA: Inferred from direct assay	7964511	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCGRT Protein Structure

MHC_I

C1-set

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

IgG receptor FcRn large subunit p51

Fc fragment of IgG receptor and transporter

Recombinant FCGRT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70601	FCRN-B2M Protein, Human (HEK293, His)	AAF72596 (A24-S297)&P61769 (I21-M119)	≥95%
HY-P71664	FCGRT Protein, Human (HEK293, His)	P55899 (A24-S297)	≥95%
HY-P72192	FCGRT Protein, Human (GST)	P55899 (A24-S297)	≥95%
HY-P72368	FCRN-B2M Protein, Human (Biotinylated, HEK293, His-Avi)	AAF72596 (A24-S297)&P61769 (I21-M119)	≥95%
HY-P73522	FCGRT-B2M Heterodimer Protein, Human (HEK293, His)	P55899 (A24-S297)&P61769 (I21-M119)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 43

Hypoproteinemia, Hypercatabolic	IMD43
Beta-2-Microglobulin Deficiency	B2m Deficiency
Hypercatabolic Hypoproteinemia

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation	Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

Immunoglobulin G Deficiency

Igg Deficiency

Igg Subclass Deficiency

Tetanus Neonatorum

Neonatal Tetanus	NNT
Trismus Neonatorum	Newborn Trismus

Epidermolysis Bullosa Acquisita

Acquired Epidermolysis Bullosa	Eb Acquisita
Eba	Eba - [Epidermolysis Bullosa Acquisita]

Neonatal Myasthenia Gravis

Myasthenia Gravis, Neonatal

Pemphigus

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Ankylosing Spondylitis 3

Transient Hypogammaglobulinemia

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Heart Block, Congenital

Congenital Heart Block	Heart Block Congenital
Congenital Atrioventricular Block

Thrombocytopenia Due To Platelet Alloimmunization

Immune Thrombocytopenia	Autoimmune Thrombocytopenia
Immune Thrombocytopenic Purpura	Itp
Auto-Immune Thrombocytopenia	Thrombocytopenia Due To Immune Destruction
Autoimmune Thrombocytopenic Purpura	Idiopathic Thrombocytopenic Purpura
Werlhof Disease

Fetal Erythroblastosis

Erythroblastosis, Fetal	Ef - Erythroblastosis Foetalis
Erythroblastosis Fetalis	Haemolytic Disease Due To Rhesus Isoimmunisation
Rhesus Isoimmunisation Of The Newborn

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Brachydactyly, Type D

Brachydactyly Type D	BDD
Stub Thumb	Brachydactyly D

Factor Viii Deficiency

Autosomal Hemophilia A	Hemophilia A
Autosomal Factor Viii Deficiency	Classic Hemophilia A
Congenital Factor Viii Disorder	Subhemophilia
Factor 8 Deficiency, Congenital	Factor Viii

Demyelinating Polyneuropathy

Peripheral Demyelinating Neuropathy

Demyelinating Peripheral Neuropathy

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04833	FCGRT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	FCGRT	VGNC	VGNC:62209
Rattus norvegicus	FCGRT	RGD	RGD:61811
Canis familiaris	FCGRT	VGNC	VGNC:40803
Mus musculus	FCGRT	MGD	MGI:103017
Bos taurus	FCGRT	VGNC	VGNC:28934
Macaca fascicularis	FCGRT	NCBI	NCBI:102128913
Others	FCGRT	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.