2. Gene
  3. THSD7A - thrombospondin type 1 domain containing 7A Gene

THSD7A - thrombospondin type 1 domain containing 7A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 221981 | Gene type: protein coding

About THSD7A

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:11,370,365-11,832,198 (from NCBI)

This gene has 4 transcripts (splice variants), 276 orthologues and 3 paralogues. Broad expression in kidney (RPKM 4.1), placenta (RPKM 2.1) and 17 other tissues.

Summary

The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) Integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis. [provided by RefSeq, Aug 2010]

THSD7A Products(1)

mRNA Protein Name
NM_015204.3 NP_056019.1 thrombospondin type-1 domain-containing protein 7A precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
27214550 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THSD7A Protein Structure

TSP_1

TSP_1: Thrombospondin type 1 domain (198 - 246)

TSP_1

TSP_1: Thrombospondin type 1 domain (364 - 412)

TSP_1

TSP_1: Thrombospondin type 1 domain (638 - 694)

TSP_1

TSP_1: Thrombospondin type 1 domain (776 - 827)

TSP_1

TSP_1: Thrombospondin type 1 domain (1039 - 1075)

TSP_1

TSP_1: Thrombospondin type 1 domain (1101 - 1138)

TSP_1

TSP_1: Thrombospondin type 1 domain (1169 - 1219)

TSP_1

TSP_1: Thrombospondin type 1 domain (1290 - 1340)

TSP_1

TSP_1: Thrombospondin type 1 domain (1346 - 1388)

TSP_1

TSP_1: Thrombospondin type 1 domain (1419 - 1474)

  • 0
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  • 1500
  • 1657 a.a.
Protein Preferred Names Protein Names

thrombospondin type-1 domain-containing protein 7A

thrombospondin, type I, domain containing 7A

THSD7A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
THSD7A Q9UPZ6 LYVE1 Homo sapiens Q9Y5Y7
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 LYVE1 Homo sapiens Q9Y5Y7
Validated Y2H
32296183
Intra
THSD7A Q9UPZ6 LYVE1 Homo sapiens Q9Y5Y7
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 ELOVL5 Homo sapiens Q9NYP7
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 ELOVL5 Homo sapiens Q9NYP7
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 LHFPL1 Homo sapiens Q86WI0
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 LHFPL1 Homo sapiens Q86WI0
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 TMUB2 Homo sapiens Q71RG4
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 TMUB2 Homo sapiens Q71RG4
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 COMT Homo sapiens P21964
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 COMT Homo sapiens P21964
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 CD33 Homo sapiens P20138
Y2H Prey Pooling
32296183
Intra
THSD7A Q9UPZ6 CD33 Homo sapiens P20138
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
THSD7A Q9UPZ6 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant THSD7A Proteins

Cat. No. Product Name Accession Purity
HY-P78044 THSD7A Protein, Human (HEK293, His) Q9UPZ6 (A48-W1607) ≥95%

Related Diseases

Diseases Alias
Membranous Nephropathy

Membranous Glomerulonephritis

Glomerulonephritis, Membranous

Idiopathic Membranous Nephropathy

Idiopathic Membranous Glomerulonephritis

MBNP

Membranous Nephropathy, Susceptibility To

Extramembranous Glomerulonephritis

Mgn

Membranous Gn

Primary Membranous Glomerulonephritis

Primary Membranous Nephropathy

Nephropathy Membranous
Bronchiectasis 3
Kimura Disease

Kimura'S Disease

Eosinophilic Lymphogranuloma

Eosinophilic Granuloma Of Soft Tissue

Eosinophilic Hyperplastic Lymphogranuloma

Eosinophilic Lymphofollicular Granuloma

Eosinophilic Lymphofolliculosis
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis
Histiocytoid Hemangioma

Angiolymphoid Hyperplasia With Eosinophilia

Epithelioid Haemangioma

Epithelioid Hemangioma
Goodpasture Syndrome

Anti-Glomerular Basement Membrane Disease

Anti-Gbm Disease

Pulmonary Renal Syndrome

Anti-Glomerular Basement Membrane Antibody Disease

Glomerulonephritis - Pulmonary Hemorrhage

Rapidly Progressive Glomerulonephritis With Pulmonary Hemorrhage

Anti-Gbm Syndrome

Goodpasture'S Syndrome

Anti-Basement Membrane Glomerulonephritis
Autoimmune Disease Of Urogenital Tract
Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis

Dense Deposit Disease

Membranoproliferative Glomerulonephritis Type 2

Primary Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis, Type Ii

Glomerulonephritis, Membranoproliferative

Chronic Glomerulonephritis, Lobular

Lobular Glomerulonephritis

Ddd

Glomerulonephritis Membranoproliferative Type 2

Mpgn 2

Membranoproliferative Glomerulonephritis Type Ii

Mesangiocapillary Glomerulonephritis Type 2

Mpgn

Primary Mpgn

Glomerulonephritis Membranoproliferative

Membranoproliferative Glomerulonephritis, Type Ii
Lipoid Nephrosis

Minimal Change Disease

Minimal Change Glomerulonephritis

Nephrotic Syndrome With Lesion Of Minimal Change Glomerulonephritis

Nephrotic Syndrome With Lesion Of Minimal Change Nephrotic Syndrome

Idiopathic Minimal Change Nephrotic Syndrome

Mcns

Minimal Change Glomerulopathy

Minimal Change Nephrotic Syndrome

Nephrotic Syndrome Minimal Change

Nephrosis, Lipoid

Glomerulonephritis, Minimal Change

Nephrotic Syndrome, Minimal Change
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14505 THSD7A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus THSD7A RGD RGD:1566201
Bos taurus THSD7A VGNC VGNC:35850
Mus musculus THSD7A MGD MGI:2685683
Canis familiaris THSD7A VGNC VGNC:47358
Macaca mulatta THSD7A VGNC VGNC:79347
Felis catus THSD7A VGNC VGNC:66176
Others THSD7A NCBI