Nr1h3 - nuclear receptor subfamily 1, group H, member 3 Gene

Mus musculus

Also known as LXR; RLD1; Unr1

Gene ID: 22259 | Gene type: protein coding

About Nr1h3

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Contributes to transcription cis-regulatory region binding activity. Involved in several processes, including lipid homeostasis; negative regulation of secretion; and regulation of transcription by RNA polymerase II. Acts upstream of or within cellular lipid metabolic process and negative regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including 1st branchial arch; genitourinary system; gut; hemolymphoid system gland; and nervous system. Used to study ovarian hyperstimulation syndrome. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h3 Products(3)

mRNA	Protein	Name
NM_001177730.1	NP_001171201.1	oxysterols receptor LXR-alpha
NM_001355279.1	NP_001342208.1	oxysterols receptor LXR-alpha
NM_013839.4	NP_038867.2	oxysterols receptor LXR-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9013544	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14739254	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9013544	MGI
enables chromatin DNA binding	IMP IMP: Inferred from mutant phenotype	29431742	MGI
contributes to nuclear receptor activity	IDA IDA: Inferred from direct assay	17107947	MGI
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	14739254	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17936707	MGI
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17107947	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular lipid metabolic process	IDA IDA: Inferred from direct assay	14739254	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	21187453	MGI
involved in cholesterol homeostasis	IGI IGI: Inferred from genetic interaction	17657314	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	18055760	MGI
involved in lipid homeostasis	IGI IGI: Inferred from genetic interaction	17657314	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	18806227	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12815040	MGI
involved in negative regulation of cholesterol storage	IGI IGI: Inferred from genetic interaction	17657314	MGI
involved in negative regulation of cold-induced thermogenesis	IGI IGI: Inferred from genetic interaction	21173252	MGI
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	21187453	MGI
involved in negative regulation of macrophage activation	IDA IDA: Inferred from direct assay	21187453	MGI
involved in negative regulation of pancreatic juice secretion	IMP IMP: Inferred from mutant phenotype	18806227	MGI
involved in negative regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	18806227	MGI
involved in negative regulation of response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	24206663	MGI
involved in negative regulation of secretion of lysosomal enzymes	IMP IMP: Inferred from mutant phenotype	18806227	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21187453	MGI
involved in phosphatidylcholine acyl-chain remodeling	IMP IMP: Inferred from mutant phenotype	24206663	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11090130	MGI
involved in positive regulation of cholesterol efflux	IDA IDA: Inferred from direct assay	16825483	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9013544	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14739254	MGI
involved in sterol homeostasis	IMP IMP: Inferred from mutant phenotype	16325781	MGI
involved in triglyceride homeostasis	IGI IGI: Inferred from genetic interaction	17657314	MGI
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	16325781	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	19167885	MGI
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	17107947	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	27383786	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14739254	MGI
located in nucleus	IMP IMP: Inferred from mutant phenotype	27383786	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

oxysterols receptor LXR-alpha

LXR alpha	liver X receptor alpha
ubiquitously-expressed nuclear receptor 1

Nr1h3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Nr1h3	Q9Z0Y9	SIRT1	Homo sapiens	Q96EB6	Anti Tag CoIP	17936707
Intra	Nr1h3	Q9Z0Y9	Men1	Mus musculus	O88559	Anti Bait CoIP	25962847

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09530	NR1H3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr1h3	NCBI	NCBI:10062

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