Mrtfa - myocardin related transcription factor A Gene

Mus musculus

Also known as Mal; AMKL; Bsac; Mkl1; Mrtf-A

Gene ID: 223701 | Gene type: protein coding

About Mrtfa

Summary

Enables several functions, including DNA-binding transcription factor activity; actin monomer binding activity; and transcription coactivator activity. Involved in actin Cytoskeleton organization and positive regulation of transcription via serum response element binding activity. Acts upstream of or within negative regulation of apoptotic process; nervous system development; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in cerebellum; early conceptus; liver; oocyte; and telencephalon. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Apr 2022]

Mrtfa Products(2)

mRNA	Protein	Name
NM_001082536.2	NP_001076005.2	myocardin-related transcription factor A isoform 2
NM_153049.3	NP_694629.2	myocardin-related transcription factor A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17991879	MGI
enables actin binding	IDA IDA: Inferred from direct assay	15798203	MGI
enables actin monomer binding	IDA IDA: Inferred from direct assay	12732141	MGI
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	19008859	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12732141	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17991879	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	12732141	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	24732378	MGI
acts upstream of or within actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	20534669	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	20534669	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	12019265	MGI
acts upstream of or within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	12019265	MGI
acts upstream of or within neuron migration	IGI IGI: Inferred from genetic interaction	20534669	MGI
acts upstream of or within neuron projection development	IGI IGI: Inferred from genetic interaction	20534669	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12019265	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17991879	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12732141	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12732141	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12019265	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

myocardin-related transcription factor A

MKL (megakaryoblastic leukemia)/myocardin-like 1	MKL/myocardin-like protein 1
basic SAP and coiled-coil domains	basic SAP coiled-coil transcription activator
megakaryoblastic leukemia (translocation) 1 homolog	megakaryocytic acute leukemia protein ho

Mrtfa Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Mrtfa	Q8K4J6	KPNB1	Homo sapiens	Q14974	Pull Down	20818336
Cross	Mrtfa	Q8K4J6	ACTB	Homo sapiens	P60709	Pull Down	19008859
Cross	Mrtfa	Q8K4J6	KPNA4	Homo sapiens	O00629	Pull Down	20818336
Cross	Mrtfa	Q8K4J6	ACTA1	Oryctolagus cuniculus	P68135	X-Ray Diffraction	19008859
Cross	Mrtfa	Q8K4J6	ACTA1	Oryctolagus cuniculus	P68135	Fluorescence	19008859

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120855	CCG-100602	Inhibitor	99.85%	Unkown
HY-13991A	(S)-CCG-1423		/	Unkown
HY-162968	MRTF-A-IN-1	Inhibitor	/	Unkown
HY-162969	MRTF-A-IN-2	Inhibitor	/	Unkown
HY-RS08693	MRTFA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mrtfa	NCBI	NCBI:57591

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