2. Gene
  3. KPNA4 - karyopherin subunit alpha 4 Gene

KPNA4 - karyopherin subunit alpha 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as QIP1; SRP3; IPOA3

Gene ID: 3840 | Gene type: protein coding

About KPNA4

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:160,495,007-160,565,571 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in heart (RPKM 11.7), esophagus (RPKM 9.8) and 25 other tissues.

Summary

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and DOCK NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]

KPNA4 Products(1)

mRNA Protein Name
NM_002268.5 NP_002259.1 importin subunit alpha-3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nuclear import signal receptor activity IDA
IDA: Inferred from direct assay
10100610 GOA
enables nuclear localization sequence binding IDA
IDA: Inferred from direct assay
20818336 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9168958 GOA
Biological Process GO Annotation Evidence Reference Source
involved in NLS-bearing protein import into nucleus IDA
IDA: Inferred from direct assay
10567565 GOA
acts upstream of positive effect dopamine secretion IDA
IDA: Inferred from direct assay
32273471 GOA
acts upstream of positive effect gene expression IDA
IDA: Inferred from direct assay
30867594 GOA
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
20818336 GOA
Cellular Component GO Annotation Evidence Reference Source
part of NLS-dependent protein nuclear import complex IPI
IPI: Inferred from physical interaction
20818336 GOA
part of nuclear pore IDA
IDA: Inferred from direct assay
10100610 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNA4 Protein Structure

IBB

IBB: Importin beta binding domain (4 - 93)

Arm

Arm: Armadillo/beta-catenin-like repeat (104 - 144)

Arm

Arm: Armadillo/beta-catenin-like repeat (146 - 184)

Arm

Arm: Armadillo/beta-catenin-like repeat (189 - 229)

Arm

Arm: Armadillo/beta-catenin-like repeat (233 - 271)

Arm

Arm: Armadillo/beta-catenin-like repeat (274 - 312)

Arm

Arm: Armadillo/beta-catenin-like repeat (315 - 355)

Arm

Arm: Armadillo/beta-catenin-like repeat (357 - 396)

Arm

Arm: Armadillo/beta-catenin-like repeat (402 - 439)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 521 a.a.
Protein Preferred Names Protein Names

importin subunit alpha-3

importin alpha Q1

KPNA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra KPNA4 O00629 MAT2B Homo sapiens Q9NZL9
Y2H Prey Pooling
25416956
Intra KPNA4 O00629 MAT2B Homo sapiens Q9NZL9
Validated Y2H
25416956
Intra KPNA4 O00629 MAT2B Homo sapiens Q9NZL9
Y2H Array
25416956
Intra KPNA4 O00629 ZNF526 Homo sapiens Q8TF50
FPS
39009827
Intra KPNA4 O00629 ABRAXAS1 Homo sapiens Q6UWZ7
FPS
39009827
Intra KPNA4 O00629 PLAA Homo sapiens Q9Y263
Y2H Array
25416956
Intra KPNA4 O00629 NUP50 Homo sapiens Q9UKX7
Validated Y2H
32296183
Intra KPNA4 O00629 NUP50 Homo sapiens Q9UKX7
Validated Y2H
25416956
Intra KPNA4 O00629 NUP50 Homo sapiens Q9UKX7
Y2H Array
25416956
Intra KPNA4 O00629 NUP50 Homo sapiens Q9UKX7
Anti Tag CoIP
35271311
Intra KPNA4 O00629 RECQL Homo sapiens P46063
Y2H
9168958
Intra KPNA4 O00629 RECQL Homo sapiens P46063
Pull Down
9168958
Intra KPNA4 O00629 KPNB1 Homo sapiens Q14974
Anti Tag CoIP
35271311
Intra KPNA4 O00629 KPNB1 Homo sapiens Q14974
Pull Down
20818336
Intra KPNA4 O00629 HNRNPC Homo sapiens P07910
Y2H Prey Pooling
25416956
Intra KPNA4 O00629 HNRNPC Homo sapiens P07910
Validated Y2H
32296183
Intra KPNA4 O00629 HNRNPC Homo sapiens P07910
Y2H Array
25416956
Intra KPNA4 O00629 TARDBP Homo sapiens Q13148
Anti Bait CoIP
26571498
Intra KPNA4 O00629 CDC45 Homo sapiens O75419
FPS
39009827
Intra KPNA4 O00629 CYHR1 Homo sapiens Q6ZMK1
Y2H Prey Pooling
25416956
Intra KPNA4 O00629 CYHR1 Homo sapiens Q6ZMK1
Y2H Array
25416956
Intra KPNA4 O00629 HSD3B7 Homo sapiens Q9H2F3
Validated Y2H
32296183
Intra KPNA4 O00629 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra KPNA4 O00629 MYC Homo sapiens P01106
FPS
37219487
Intra KPNA4 O00629 MYC Homo sapiens P01106
FPS
35044719
Cross KPNA4 O00629 lt_sv40 Simian virus 40 P03070
Pull Down
20701745
Intra KPNA4 O00629 NCBP3 Homo sapiens Q53F19
Validated Y2H
32296183
Intra KPNA4 O00629 MTA1 Homo sapiens Q13330
Anti Tag CoIP
35271311
Intra KPNA4 O00629 MTA1 Homo sapiens Q13330
Validated Y2H
32296183
Intra KPNA4 O00629 FAM50B Homo sapiens Q9Y247
Validated Y2H
32296183
Intra KPNA4 O00629 NCOR2 Homo sapiens Q9Y618
FPS
35044719
Intra KPNA4 O00629 CREBBP Homo sapiens Q92793
FPS
39009827
Cross KPNA4 O00629 Mrtfa Mus musculus Q8K4J6
Pull Down
20818336
Intra KPNA4 O00629 RANBP3 Homo sapiens Q9H6Z4
Phage Display
37219487
Intra KPNA4 O00629 RANBP3 Homo sapiens Q9H6Z4
FPS
37219487
Cross KPNA4 O00629 ORF4b Middle East respiratory syndrome-related coronavirus K9N643
Anti Tag CoIP
29370303
Cross KPNA4 O00629 P04585-PRO_0000042447 Human immunodeficiency virus P04585-PRO_0000042447
Pull Down
20554775
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07418 KPNA4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KPNA4 VGNC VGNC:42502
Macaca mulatta KPNA4 VGNC VGNC:74201
Bos taurus KPNA4 VGNC VGNC:30703
Mus musculus KPNA4 MGD MGI:1100848
Rattus norvegicus KPNA4 RGD RGD:1311483
Felis catus KPNA4 VGNC VGNC:67976