KPNA4 - karyopherin subunit alpha 4 Gene

Homo sapiens

Also known as QIP1; SRP3; IPOA3

Gene ID: 3840 | Gene type: protein coding

About KPNA4

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:160,495,007-160,565,571 (from NCBI)

This gene has 11 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in heart (RPKM 11.7), esophagus (RPKM 9.8) and 25 other tissues.

Summary

The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and DOCK NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]

KPNA4 Products(1)

mRNA	Protein	Name
NM_002268.5	NP_002259.1	importin subunit alpha-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables nuclear import signal receptor activity	IDA IDA: Inferred from direct assay	10100610	GOA
enables nuclear localization sequence binding	IDA IDA: Inferred from direct assay	20818336	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9168958	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in NLS-bearing protein import into nucleus	IDA IDA: Inferred from direct assay	10567565	GOA
acts upstream of positive effect dopamine secretion	IDA IDA: Inferred from direct assay	32273471	GOA
acts upstream of positive effect gene expression	IDA IDA: Inferred from direct assay	30867594	GOA
involved in protein import into nucleus	IDA IDA: Inferred from direct assay	20818336	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NLS-dependent protein nuclear import complex	IPI IPI: Inferred from physical interaction	20818336	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	10100610	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNA4 Protein Structure

IBB

Arm

0
100
200
300
400
521 a.a.

Protein Preferred Names

Protein Names

importin subunit alpha-3

importin alpha Q1

KPNA4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KPNA4	O00629	MAT2B	Homo sapiens	Q9NZL9	Y2H Prey Pooling	25416956
Intra	KPNA4	O00629	MAT2B	Homo sapiens	Q9NZL9	Validated Y2H	25416956
Intra	KPNA4	O00629	MAT2B	Homo sapiens	Q9NZL9	Y2H Array	25416956
Intra	KPNA4	O00629	ZNF526	Homo sapiens	Q8TF50	FPS	39009827
Intra	KPNA4	O00629	ABRAXAS1	Homo sapiens	Q6UWZ7	FPS	39009827
Intra	KPNA4	O00629	PLAA	Homo sapiens	Q9Y263	Y2H Array	25416956
Intra	KPNA4	O00629	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	32296183
Intra	KPNA4	O00629	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	25416956
Intra	KPNA4	O00629	NUP50	Homo sapiens	Q9UKX7	Y2H Array	25416956
Intra	KPNA4	O00629	NUP50	Homo sapiens	Q9UKX7	Anti Tag CoIP	35271311
Intra	KPNA4	O00629	RECQL	Homo sapiens	P46063	Y2H	9168958
Intra	KPNA4	O00629	RECQL	Homo sapiens	P46063	Pull Down	9168958
Intra	KPNA4	O00629	KPNB1	Homo sapiens	Q14974	Anti Tag CoIP	35271311
Intra	KPNA4	O00629	KPNB1	Homo sapiens	Q14974	Pull Down	20818336
Intra	KPNA4	O00629	HNRNPC	Homo sapiens	P07910	Y2H Prey Pooling	25416956
Intra	KPNA4	O00629	HNRNPC	Homo sapiens	P07910	Validated Y2H	32296183
Intra	KPNA4	O00629	HNRNPC	Homo sapiens	P07910	Y2H Array	25416956
Intra	KPNA4	O00629	TARDBP	Homo sapiens	Q13148	Anti Bait CoIP	26571498
Intra	KPNA4	O00629	CDC45	Homo sapiens	O75419	FPS	39009827
Intra	KPNA4	O00629	CYHR1	Homo sapiens	Q6ZMK1	Y2H Prey Pooling	25416956
Intra	KPNA4	O00629	CYHR1	Homo sapiens	Q6ZMK1	Y2H Array	25416956
Intra	KPNA4	O00629	HSD3B7	Homo sapiens	Q9H2F3	Validated Y2H	32296183
Intra	KPNA4	O00629	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	KPNA4	O00629	MYC	Homo sapiens	P01106	FPS	37219487
Intra	KPNA4	O00629	MYC	Homo sapiens	P01106	FPS	35044719
Cross	KPNA4	O00629	lt_sv40	Simian virus 40	P03070	Pull Down	20701745
Intra	KPNA4	O00629	NCBP3	Homo sapiens	Q53F19	Validated Y2H	32296183
Intra	KPNA4	O00629	MTA1	Homo sapiens	Q13330	Anti Tag CoIP	35271311
Intra	KPNA4	O00629	MTA1	Homo sapiens	Q13330	Validated Y2H	32296183
Intra	KPNA4	O00629	FAM50B	Homo sapiens	Q9Y247	Validated Y2H	32296183
Intra	KPNA4	O00629	NCOR2	Homo sapiens	Q9Y618	FPS	35044719
Intra	KPNA4	O00629	CREBBP	Homo sapiens	Q92793	FPS	39009827
Cross	KPNA4	O00629	Mrtfa	Mus musculus	Q8K4J6	Pull Down	20818336
Intra	KPNA4	O00629	RANBP3	Homo sapiens	Q9H6Z4	Phage Display	37219487
Intra	KPNA4	O00629	RANBP3	Homo sapiens	Q9H6Z4	FPS	37219487
Cross	KPNA4	O00629	ORF4b	Middle East respiratory syndrome-related coronavirus	K9N643	Anti Tag CoIP	29370303
Cross	KPNA4	O00629	P04585-PRO_0000042447	Human immunodeficiency virus	P04585-PRO_0000042447	Pull Down	20554775

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07418	KPNA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	KPNA4	VGNC	VGNC:42502
Macaca mulatta	KPNA4	VGNC	VGNC:74201
Bos taurus	KPNA4	VGNC	VGNC:30703
Mus musculus	KPNA4	MGD	MGI:1100848
Rattus norvegicus	KPNA4	RGD	RGD:1311483
Felis catus	KPNA4	VGNC	VGNC:67976

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