1. Gene
  2. Pik3c3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

Pik3c3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

Mus musculus

Also known as Vps34; 5330434F23Rik

Gene ID: 225326 | Gene type: protein coding

About Pik3c3

Chromosome 18: 30,405,800-30,481,179 forward strand.GRCm39:CM001011.3

This gene has 4 transcripts (splice variants), 210 orthologues, 9 paralogues and is associated with 19 phenotypes. Broad expression in CNS E14 (RPKM 15.), CNS E18 (RPKM 11.) and 24 other tissues.

Summary

Enables protein kinase activity. Involved in cellular response to glucose starvation and macroautophagy. Acts upstream of or within several processes, including cellular response to starvation; phosphatidylinositol-3-phosphate biosynthetic process; and protein localization to phagophore assembly site. Located in phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in Meckel's cartilage; cardiovascular system; limb; and skeleton. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c3 Products(1)

mRNA Protein Name
NM_181414.6 NP_852079.2 phosphatidylinositol 3-kinase catalytic subunit type 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22493499 MGI
enables protein kinase activity IMP
IMP: Inferred from mutant phenotype
15010863 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within autophagosome assembly IMP
IMP: Inferred from mutant phenotype
24098492 MGI
involved in cellular response to glucose starvation IDA
IDA: Inferred from direct assay
23332761 MGI
acts upstream of or within cellular response to starvation IMP
IMP: Inferred from mutant phenotype
24098492 MGI
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
23332761 MGI
acts upstream of or within phosphatidylinositol-3-phosphate biosynthetic process IMP
IMP: Inferred from mutant phenotype
24098492 MGI
acts upstream of or within protein localization to phagophore assembly site IMP
IMP: Inferred from mutant phenotype
24098492 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
15010863 MGI
involved in synaptic vesicle endocytosis EXP
EXP: Inferred from Experiment
35318705 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
35318705 MGI
involved in synaptic vesicle endocytosis IEP
IEP: Inferred from expression pattern
35318705 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
35318705 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
35318705 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
35318705 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
35318705 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
22493499 MGI
part of phosphatidylinositol 3-kinase complex, class III IDA
IDA: Inferred from direct assay
23332761 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
20955765 MGI
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
20955765 MGI
is active in postsynaptic endosome IDA
IDA: Inferred from direct assay
35318705 MGI
is active in postsynaptic endosome IMP
IMP: Inferred from mutant phenotype
35318705 MGI
is active in presynaptic endosome IDA
IDA: Inferred from direct assay
35318705 MGI
is active in presynaptic endosome IMP
IMP: Inferred from mutant phenotype
35318705 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3c3 Protein Structure

C2_PI3K_class_III

C2_PI3K_class_III: cd08397 (25 - 185)

PI3Ka_III

PI3Ka_III: cd00870 (282 - 502)

PI3Kc_III

PI3Kc_III: cd00896 (538 - 882)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3-kinase catalytic subunit type 3

PI3-kinase type 3

PI3K type 3

phosphoinositide-3-kinase, class 3

ptdIns-3-kinase type 3

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3c3 NCBI NCBI:5289