2. Gene
  3. Pik3c3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

Pik3c3 - phosphatidylinositol 3-kinase catalytic subunit type 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Vps34; 5330434F23Rik

Gene ID: 225326 | Gene type: protein coding

About Pik3c3

Chromosome 18: 30,405,800-30,481,179 forward strand.GRCm39:CM001011.3

This gene has 4 transcripts (splice variants), 210 orthologues, 9 paralogues and is associated with 19 phenotypes. Broad expression in CNS E14 (RPKM 15.), CNS E18 (RPKM 11.) and 24 other tissues.

Summary

Enables protein kinase activity. Involved in cellular response to glucose starvation and macroautophagy. Acts upstream of or within several processes, including cellular response to starvation; phosphatidylinositol-3-phosphate biosynthetic process; and protein localization to phagophore assembly site. Located in phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in Meckel's cartilage; cardiovascular system; limb; and skeleton. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c3 Products(1)

mRNA Protein Name
NM_181414.6 NP_852079.2 phosphatidylinositol 3-kinase catalytic subunit type 3

Pik3c3 Protein Structure

C2_PI3K_class_III

C2_PI3K_class_III: cd08397 (25 - 185)

PI3Ka_III

PI3Ka_III: cd00870 (282 - 502)

PI3Kc_III

PI3Kc_III: cd00896 (538 - 882)

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  • 887 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3-kinase catalytic subunit type 3

PI3-kinase type 3

PI3K type 3

phosphoinositide-3-kinase, class 3

ptdIns-3-kinase type 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12481 SAR405 Inhibitor 99.49% Unkown
HY-137506 XST-14 99.26% Unkown
HY-12481A SAR405 R enantiomer 99.94% Unkown
HY-RS10520 PIK3C3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10521 Pik3c3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10522 Pik3c3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3c3 NCBI NCBI:5289