Becn1 - beclin 1, autophagy related Gene

Mus musculus

Also known as Atg6

Gene ID: 56208 | Gene type: protein coding

About Becn1

Chromosome 11: 101,176,778-101,193,112 reverse strand.GRCm39:CM001004.3

This gene has 17 transcripts (splice variants), 214 orthologues, 1 paralogue and is associated with 43 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 39.6), bladder adult (RPKM 35.6) and 28 other tissues.

Summary

Enables identical protein binding activity. Involved in several processes, including Autophagy of mitochondrion; cellular response to glucose starvation; and engulfment of apoptotic cell. Acts upstream of or within several processes, including amyloid-beta metabolic process; negative regulation of autophagosome assembly; and positive regulation of cardiac muscle hypertrophy. Located in autophagosome; phagocytic vesicle; and trans-Golgi network. Part of phosphatidylinositol 3-kinase complex, class III. Is expressed in central nervous system; extraembryonic visceral endoderm; sensory organ; and spleen. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Machado-Joseph disease. Orthologous to human BECN1 (beclin 1). [provided by Alliance of Genome Resources, Apr 2022]

Becn1 Products(4)

mRNA	Protein	Name
NM_001359820.1	NP_001346749.1	beclin-1 isoform 3
NM_001359821.1	NP_001346750.1	beclin-1 isoform 4
NM_001359819.1	NP_001346748.1	beclin-1 isoform 2
NM_019584.4	NP_062530.2	beclin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	27994061	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12372286	MGI
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	25275521	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within amyloid-beta metabolic process	IMP IMP: Inferred from mutant phenotype	18497889	MGI
involved in autophagosome assembly	IMP IMP: Inferred from mutant phenotype	23332761	MGI
acts upstream of or within autophagy	IDA IDA: Inferred from direct assay	12372286	MGI
involved in autophagy	IDA IDA: Inferred from direct assay	23364696	MGI
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	23332761	MGI
involved in engulfment of apoptotic cell	IMP IMP: Inferred from mutant phenotype	22393062	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	18497889	MGI
acts upstream of or within macroautophagy	IGI IGI: Inferred from genetic interaction	17468177	MGI
acts upstream of or within macroautophagy	IMP IMP: Inferred from mutant phenotype	14657337	MGI
involved in macroautophagy	IMP IMP: Inferred from mutant phenotype	23332761	MGI
acts upstream of or within negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	27994061	MGI
acts upstream of or within negative regulation of autophagy	IMP IMP: Inferred from mutant phenotype	27994061	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17589504	MGI
acts upstream of or within neuron development	IMP IMP: Inferred from mutant phenotype	18497889	MGI
acts upstream of or within positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	27994061	MGI
acts upstream of or within regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	22493499	MGI
acts upstream of or within response to other organism	IDA IDA: Inferred from direct assay	9765397	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in autophagosome	IDA IDA: Inferred from direct assay	23798385	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	22498477	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17589504	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12372286	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	22493499	MGI
part of phosphatidylinositol 3-kinase complex, class III	IDA IDA: Inferred from direct assay	23332761	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17891140	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12372286	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Becn1 Protein Structure

BH3

APG6_N

APG6

0
100
200
300
400
448 a.a.

Protein Preferred Names

Protein Names

beclin-1

Bcl-2-interacting protein beclin	Beclin-1
coiled-coil, myosin-like BCL2-interacting protein

Becn1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Becn1	O88597	Nrbf2	Mus musculus	Q8VCQ3	Anti Bait CoIP	24849286
Intra	Becn1	O88597	Nrbf2	Mus musculus	Q8VCQ3	Anti Tag CoIP	24849286
Intra	Becn1	O88597	Gopc	Mus musculus	Q8BH60	IF	12372286
Intra	Becn1	O88597	Gopc	Mus musculus	Q8BH60	Y2H	12372286
Intra	Becn1	O88597	Gopc	Mus musculus	Q8BH60	Anti Tag CoIP	12372286
Intra	Becn1	O88597	Bcl2	Mus musculus	P10417	Anti Bait CoIP	29849149
Intra	Becn1	O88597	Bcl2	Mus musculus	P10417	Anti Bait CoIP	20819940
Intra	Becn1	O88597	Hmgb1	Mus musculus	P63158	Anti Bait CoIP	20819940
Intra	Becn1	O88597	Pik3c3	Mus musculus	Q6PF93	Anti Tag CoIP	24849286
Intra	Becn1	O88597	Pik3c3	Mus musculus	Q6PF93	Anti Bait CoIP	23332761

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137506	XST-14		99.26%	Unkown
HY-149954	SARS-CoV-2-IN-39	Inhibitor	99.51%	Unkown
HY-167843	Alborixin	Inhibitor	/	Unkown
HY-RS01463	BECN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01464	Becn1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01465	Becn1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Becn1	NCBI	NCBI:8678

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