2. Gene
  3. Ina - internexin neuronal intermediate filament protein, alpha Gene

Ina - internexin neuronal intermediate filament protein, alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NF66; NF-66; alpha-Inx

Gene ID: 226180 | Gene type: protein coding

About Ina

Summary

A structural constituent of postsynaptic actin Cytoskeleton and structural constituent of postsynaptic intermediate filament Cytoskeleton. Acts upstream of or within cellular response to Leukemia Inhibitory Factor and neurofilament Cytoskeleton organization. Located in Schaffer collateral - CA1 synapse and neurofilament. Is active in postsynapse. Is expressed in several structures, including gut; nervous system; neural ectoderm; and sensory organ. Orthologous to human INA (internexin neuronal intermediate filament protein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ina Products(1)

mRNA Protein Name
NM_146100.5 NP_666212.3 alpha-internexin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21689717 MGI
enables structural constituent of postsynaptic intermediate filament cytoskeleton IDA
IDA: Inferred from direct assay
25869803 MGI
enables structural constituent of postsynaptic intermediate filament cytoskeleton IMP
IMP: Inferred from mutant phenotype
25869803 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within intermediate filament cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
14561875 MGI
acts upstream of or within neurofilament cytoskeleton organization IGI
IGI: Inferred from genetic interaction
10350642 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
25869803 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
25869803 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
25869803 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
25869803 MGI
located in neurofilament IDA
IDA: Inferred from direct assay
10221457 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
25869803 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-internexin

66 kDa neurofilament protein

neurofilament-66

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0280 Ranolazine Inhibitor 99.79% Yes
HY-17401 Ranolazine dihydrochloride 99.82% Yes
HY-108767 Insulin aspart ≥95.0% Unkown
Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110195 Smurf1-IN-A01 99.81% Unkown
HY-12593 GS967 Inhibitor 99.77% Unkown
HY-148792 Relutrigine Inhibitor 99.13% Unkown
HY-108579 UCL 1684 dibromide Inhibitor 98.07% Unkown
HY-144652 IDO1-IN-19 Inhibitor 98.52% Unkown
HY-N6868 Dimethyl lithospermate B Agonist 98.85% Unkown
HY-B0280S2 Ranolazine-d3 Inhibitor 99.49% Unkown
HY-111245 AZD-1305 Inhibitor / Unkown
HY-126005 VGSC blocker-1 Inhibitor / Unkown
HY-156976 Sulcardine Inhibitor / Unkown
HY-163549 APN-PEG5-VC-PAB-MMAE / Unkown
HY-17401S Ranolazine-d8 dihydrochloride ≥99.0% Unkown
HY-B0280S Ranolazine-d5 Inhibitor / Unkown
HY-B0280S1 Ranolazine-d8 Inhibitor 99.83% Unkown
HY-RS06802 INA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-156976A Sulcardine hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ina NCBI NCBI:9118
Canis familiaris Ina NCBI NCBI:486869
Macaca fascicularis Ina NCBI NCBI:102135892
Canis lupus familiaris Ina NCBI
Susscrofa domestica Ina NCBI
Leporidae Ina NCBI
Rattus norvegicus Ina NCBI NCBI:24503
Macaca mulatta Ina NCBI NCBI:714455