GPC5 - glypican 5 Gene

Homo sapiens

Gene ID: 2262 | Gene type: protein coding

About GPC5

Cytogenetic location: 13q31.3 Genomic coordinates (GRCh38): 13:91,398,621-92,867,237 (from NCBI)

This gene has 4 transcripts (splice variants), 189 orthologues, 5 paralogues and is associated with 83 phenotypes. Biased expression in brain (RPKM 1.8), testis (RPKM 1.4) and 7 other tissues.

Summary

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]

GPC5 Products(1)

mRNA	Protein	Name
NM_004466.6	NP_004457.1	glypican-5 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30282023	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPC5 Protein Structure

Glypican

0
100
200
300
400
500
572 a.a.

Protein Preferred Names

Protein Names

glypican-5

bA93M14.1

Recombinant GPC5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73079	Glypican-5/GPC5 Protein, Human (sf9, His)	P78333/NP_004457.1 (E25-T554)	≥95%

Related Diseases

Diseases

Alias

Omodysplasia

Omodysplasia Type 1

Omodysplasia 2

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Keipert Syndrome

Nasodigitoacoustic Syndrome	KPTS
Nasodigitoacoustic Syndrome, Formerly

Simpson-Golabi-Behmel Syndrome, Type 1

Simpson-Golabi-Behmel Syndrome Type 1	Simpson-Golabi-Behmel Syndrome
SGBS1	Golabi-Rosen Syndrome
Simpson Dysmorphia Syndrome	Sgbs
Bulldog Syndrome	Dgsx
Sdys	Dysplasia Gigantism Syndrome, X-Linked
X-Linked Dysplasia Gigantism Syndrome	Dgsx Golabi-Rosen Syndrome
Sara Angers Syndrome	Sgb Syndrome
Mental Retardation-Overgrowth Syndrome	Simpson Dysplasia Syndrome
Simpson Syndrome	Simpson-Golabi-Behmel Syndrome 1
Dysplasia Gigantism Syndrome X-Linked

Hereditary Multiple Exostoses

Multiple Congenital Exostosis	Hereditary Multiple Exostoses 1
Hereditary Multiple Exostoses 2	Hereditary Multiple Exostoses 3
Multiple Exostosis Syndromes	Multiple Ostechondromas
Osteochondromatosis Syndrome	Exostoses Multiple Hereditary
Exostoses, Multiple Hereditary

Tetralogy Of Fallot

TOF	Fallot Tetralogy
Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle	Tetrad Of Fallot
Fallot Tetrad	Fallot Disease
Fallot Complex	Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy
Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle	Interventricular Septal Defect, In Tetralogy Of Fallot
Ventricular Septal Defect With Obstructed Right Ventricular Outflow	Tof - [Tetralogy Of Fallot]
Pulmonary Atresia With Ventricular Septal Defect [Fallot Type]	Pulmonary Atresia, Ventricular Septal Defect And Mapcas
Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Feingold Syndrome 1

Feingold Syndrome	Oculodigitoesophagoduodenal Syndrome
Oded Syndrome	Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome
Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum	FGLDS1
Mmt Syndrome	Brunner-Winter Syndrome
Feingold Syndrome Type 1	Oded
Moded	Fglds
Microcephaly-Digital Anomalies-Normal Intelligence Syndrome	Moded Syndrome
Oculo-Digito-Esophageal-Duodenal Syndrome	Microcephaly, Mental Retardation, And Tracheoesophageal Fistula Syndrome
Microcephaly And Digital Abnormalities With Normal Intelligence	Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus, Or Duodenum
Microcephaly-Mesobrachyphalangy-Tracheoesophageal Fistula Syndrome	Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome
Oculo-Digito-Esophagoduodental Syndrome	Fs
Mmt	Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome
Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome	Brunner-Winter Syndrome Type 1
Digital Anomalies With Short Palpebral Fissures And Atresia Of Esophagus Or Duodenum Type 1	Fs1
Mmt Type 1	Moded Syndrome Type 1
Microcephaly-Digital Anomalies-Normal Intelligence Syndrome Type 1	Microcephaly-Intellectual Disability-Tracheoesophageal Fistula Syndrome Type 1
Microcephaly-Oculo-Digito-Esophageal-Duodenal Syndrome Syndrome Type 1	Oded Syndrome Type 1
Oculo-Digito-Esophageal-Duodenal Syndrome Type 1	Feingold Syndrome, Type 1

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Rhabdomyosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05630	GPC5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GPC5	RGD	RGD:1308835
Canis familiaris	GPC5	VGNC	VGNC:49903
Macaca mulatta	GPC5	VGNC	VGNC:73119
Felis catus	GPC5	VGNC	VGNC:102214
Bos taurus	GPC5	VGNC	VGNC:29527
Mus musculus	GPC5	MGD	MGI:1194894
Others	GPC5	NCBI

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