Dyrk3 - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 Gene

Mus musculus

Gene ID: 226419 | Gene type: protein coding

About Dyrk3

Chromosome 1: 131,055,192-131,066,077 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 201 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in testis adult (RPKM 67.2), liver E14.5 (RPKM 1.2) and 7 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including erythrocyte differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; and protein phosphorylation. Predicted to be located in several cellular components, including cytoplasmic stress granule; nuclear speck; and pericentriolar material. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; musculature; nasal cavity epithelium; and reproductive system. Orthologous to human DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk3 Products(1)

mRNA	Protein	Name
NM_145508.2	NP_663483.1	dual specificity tyrosine-phosphorylation-regulated kinase 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12356771	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	12356771	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20167603	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	12356771	MGI
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	20167603	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in erythrocyte differentiation	IDA IDA: Inferred from direct assay	16524748	MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	20167603	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20167603	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12356771	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dyrk3 Protein Structure

PKc_DYRK2_3

0
100
200
300
400
500
586 a.a.

Protein Preferred Names

Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 3

Dyrk3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Dyrk3	Q922Y0	Sirt1	Mus musculus	Q923E4	Protein Kinase Assay	20167603
Intra	Dyrk3	Q922Y0	Sirt1	Mus musculus	Q923E4	IF	20167603

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-105309	GSK-626616	Inhibitor	99.77%	Unkown
HY-162750	ZJCK-6-46	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dyrk3	NCBI	NCBI:8444

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