Gpbar1 - G protein-coupled bile acid receptor 1 Gene

Mus musculus

Also known as BG37; GPCR; TGR5; M-BAR; GPR131

Gene ID: 227289 | Gene type: protein coding

About Gpbar1

Chromosome 1: 74,317,709-74,318,783 forward strand.GRCm39:CM000994.3

This gene has 1 transcript (splice variant), 75 orthologues and is associated with 24 phenotypes.

Summary

Predicted to enable G protein-coupled bile acid receptor activity. Involved in regulation of bicellular tight junction assembly. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of receptor complex. Is expressed in gut and male reproductive gland or organ. Orthologous to human GPBAR1 (G protein-coupled Bile Acid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Gpbar1 Products(1)

mRNA	Protein	Name
NM_174985.2	NP_778150.1	G-protein coupled bile acid receptor 1

Gpbar1 Protein Structure

7tm_GPCRs

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

G-protein coupled bile acid receptor 1

G protein-coupled receptor TGR5	membrane bile acid receptor
membrane-type receptor for bile acids

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101273	BAR502	Agonist	99.53%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101274	BAR501	Agonist	≥98.0%	Unkown
HY-147086	CAY10789		99.84%	Unkown
HY-145234	GPBAR1-IN-3		/	Unkown
HY-107612	GPBAR-A	Agonist	/	Unkown
HY-146453	TGR5 Receptor Agonist 3	Agonist	/	Unkown
HY-RS05622	GPBAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05623	Gpbar1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05624	Gpbar1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-165155	CysLT1 receptor antagonist-1	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpbar1	NCBI	NCBI:151306

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