FRMPD1 - FERM and PDZ domain containing 1 Gene

Homo sapiens

Also known as FRMD2

Gene ID: 22844 | Gene type: protein coding

About FRMPD1

Cytogenetic location: 9p13.2 Genomic coordinates (GRCh38): 9:37,603,229-37,746,904 (from NCBI)

This gene has 3 transcripts (splice variants), 278 orthologues and 2 paralogues. Biased expression in testis (RPKM 3.6), skin (RPKM 1.1) and 2 other tissues.

Summary

Involved in establishment of protein localization to membrane and regulation of G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of protein-containing complex. Colocalizes with cell cortex. [provided by Alliance of Genome Resources, Apr 2022]

FRMPD1 Products(4)

mRNA	Protein	Name
NM_001371223.1	NP_001358152.1	FERM and PDZ domain-containing protein 1
NM_001371224.1	NP_001358153.1	FERM and PDZ domain-containing protein 1
NM_001371225.1	NP_001358154.1	FERM and PDZ domain-containing protein 1
NM_014907.3	NP_055722.2	FERM and PDZ domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18566450	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in establishment of protein localization to membrane	IMP IMP: Inferred from mutant phenotype	18566450	GOA
involved in regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18566450	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with cell cortex	IMP IMP: Inferred from mutant phenotype	18566450	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	18566450	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	22074847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRMPD1 Protein Structure

PDZ

FERM_N

FERM_M

0
300
600
900
1200
1578 a.a.

Protein Preferred Names

Protein Names

FERM and PDZ domain-containing protein 1

FERM domain-containing protein 2

FRMPD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FRMPD1	Q5SYB0	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage	Familial Berry Aneurysm
Familial Intracranial Saccular Aneurysm	Saccular Cerebral Aneurysm
Aneurysm, Intracranial Berry	Aneurysmal Subarachnoid Hemorrhage
Aneurysm, Intracranial Berry, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05107	FRMPD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FRMPD1	VGNC	VGNC:52780
Felis catus	FRMPD1	VGNC	VGNC:62364
Rattus norvegicus	FRMPD1	RGD	RGD:1305229
Macaca mulatta	FRMPD1	VGNC	VGNC:72804
Mus musculus	FRMPD1	MGD	MGI:2446274
Canis familiaris	FRMPD1	VGNC	VGNC:51720

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