FKBP2 - FKBP prolyl isomerase 2 Gene

Homo sapiens

Also known as FKBP13; PPIase; FKBP-13

Gene ID: 2286 | Gene type: protein coding

About FKBP2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,241,095-64,244,135 (from NCBI)

This gene has 6 transcripts (splice variants), 198 orthologues and 18 paralogues. Ubiquitous expression in kidney (RPKM 33.5), thyroid (RPKM 33.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

FKBP2 Products(8)

mRNA	Protein	Name
NM_001135208.2	NP_001128680.1	peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor
NM_001370360.1	NP_001357289.1	peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor
NM_001370362.1	NP_001357291.1	peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor
NM_001370363.1	NP_001357292.1	peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor
NM_001370365.1	NP_001357294.1	peptidyl-prolyl cis-trans isomerase FKBP2 isoform 2
NM_001370367.1	NP_001357296.1	peptidyl-prolyl cis-trans isomerase FKBP2 isoform 3
NM_004470.4	NP_004461.2	peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor
NM_057092.2	NP_476433.1	peptidyl-prolyl cis-trans isomerase FKBP2 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FKBP2 Protein Structure

FKBP_C

0
100
142 a.a.

Protein Preferred Names

Protein Names

peptidyl-prolyl cis-trans isomerase FKBP2

13 kDa FK506-binding protein

FKBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FKBP2	P26885	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	FKBP2	P26885	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	FKBP2	P26885	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	FKBP2	P26885	UBQLN4	Homo sapiens	Q9NRR5	Y2H Array	16713569
Intra	FKBP2	P26885	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	25416956
Intra	FKBP2	P26885	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	FKBP2	P26885	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	FKBP2	P26885	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	FKBP2	P26885	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	FKBP2	P26885	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	FKBP2	P26885	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FKBP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70333	FKBP2 Protein, Human (HEK293, His)	P26885 (A22-L142)	≥95%

Related Diseases

Diseases

Alias

Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 2

Ehlers-Danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss	EDSKSCL2
Edskmh	Ehlers-Danlos Syndrome Kyphoscoliotic Type 2
Kyphoscoliotic Ehlers-Danlos Syndrome Due To Fkbp22 Deficiency	Ehlers-Danlos Syndrome With Kyphoscoliosis, Myopathy, And Deafness
Ehlers-Danlos Syndrome With Kyphoscoliosis, Myopathy, And Hearing Loss	Fkbp14-Related Eds
Fkbp22-Deficient Eds	Kyphoscoliotic Eds Due To Fkbp22 Deficiency
Keds-Fkbp14	Ehlers-Danlos Syndrome, With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss
Ehlers-Danlos Syndrome, Kyphoscoliotic, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04962	FKBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FKBP2	VGNC	VGNC:110506
Mus musculus	FKBP2	MGD	MGI:95542
Canis familiaris	FKBP2	VGNC	VGNC:40889
Felis catus	FKBP2	VGNC	VGNC:101458
Others	FKBP2	NCBI

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