2. Gene
  3. ABLIM3 - actin binding LIM protein family member 3 Gene

ABLIM3 - actin binding LIM protein family member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HMFN1661

Gene ID: 22885 | Gene type: protein coding

About ABLIM3

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:149,141,493-149,260,542 (from NCBI)

This gene has 12 transcripts (splice variants), 288 orthologues and 3 paralogues. Broad expression in fat (RPKM 33.5), heart (RPKM 19.5) and 14 other tissues.

Summary

This gene encodes a member of the actin-binding LIM (abLIM) family of proteins. These proteins are characterized by an N-terminal LIM domain and a C-terminal dematin-like domain. The encoded protein interacts with actin filaments and may be a component of adherens junctions in several cell types. A variant of this gene may be associated with pain sensitivity in male human patients. [provided by RefSeq, Sep 2016]

ABLIM3 Products(10)

mRNA Protein Name
NM_001301015.3 NP_001287944.1 actin-binding LIM protein 3 isoform 1
NM_001301018.3 NP_001287947.1 actin-binding LIM protein 3 isoform 2
NM_001301028.3 NP_001287957.1 actin-binding LIM protein 3 isoform 4
NM_001345858.2 NP_001332787.1 actin-binding LIM protein 3 isoform 5
NM_001345859.2 NP_001332788.1 actin-binding LIM protein 3 isoform 6
NM_001345860.2 NP_001332789.1 actin-binding LIM protein 3 isoform 7
NM_001345861.2 NP_001332790.1 actin-binding LIM protein 3 isoform 6
NM_001370417.1 NP_001357346.1 actin-binding LIM protein 3 isoform 2
NM_001370418.1 NP_001357347.1 actin-binding LIM protein 3 isoform 7
NM_014945.5 NP_055760.1 actin-binding LIM protein 3 isoform 1

ABLIM3 Protein Structure

LIM

LIM: LIM domain (23 - 76)

LIM

LIM: LIM domain (82 - 135)

LIM

LIM: LIM domain (151 - 206)

LIM

LIM: LIM domain (210 - 263)

VHP

VHP: Villin headpiece domain (648 - 683)

  • 0
  • 200
  • 400
  • 600
  • 683 a.a.
Protein Preferred Names Protein Names

actin-binding LIM protein 3

abLIM-3

ABLIM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ABLIM3 O94929 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
Intra
ABLIM3 O94929 IKZF3 Homo sapiens Q9UKT9
Y2H Array
31515488
Intra
ABLIM3 O94929 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
25416956
Intra
ABLIM3 O94929 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00108 ABLIM3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ABLIM3 VGNC VGNC:25509
Mus musculus ABLIM3 MGD MGI:2442582
Canis familiaris ABLIM3 VGNC VGNC:37480
Rattus norvegicus ABLIM3 RGD RGD:1565118
Felis catus ABLIM3 VGNC VGNC:59491
Macaca mulatta ABLIM3 VGNC VGNC:69546