2. Gene
  3. SSX2IP - SSX family member 2 interacting protein Gene

SSX2IP - SSX family member 2 interacting protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ADIP; hMsd1

Gene ID: 117178 | Gene type: protein coding

About SSX2IP

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:84,643,706-84,690,745 (from NCBI)

This gene has 10 transcripts (splice variants) and 276 orthologues. Broad expression in testis (RPKM 29.1), duodenum (RPKM 14.3) and 19 other tissues.

Summary

This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009]

SSX2IP Products(5)

mRNA Protein Name
NM_001166293.2 NP_001159765.1 afadin- and alpha-actinin-binding protein isoform 1
NM_001166294.2 NP_001159766.1 afadin- and alpha-actinin-binding protein isoform 2
NM_001166295.2 NP_001159767.1 afadin- and alpha-actinin-binding protein isoform 2
NM_001166417.2 NP_001159889.1 afadin- and alpha-actinin-binding protein isoform 1
NM_014021.4 NP_054740.3 afadin- and alpha-actinin-binding protein isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12007189 GOA
Biological Process GO Annotation Evidence Reference Source
involved in centrosome cycle IMP
IMP: Inferred from mutant phenotype
23816619 GOA
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
24356449 GOA
involved in intraciliary transport involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
24356449 GOA
Cellular Component GO Annotation Evidence Reference Source
located in centriolar satellite IDA
IDA: Inferred from direct assay
23816619 GOA
located in ciliary basal body IDA
IDA: Inferred from direct assay
24356449 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

afadin- and alpha-actinin-binding protein

SSX2-interacting protein

SSX2IP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SSX2IP Q9Y2D8 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 a8k932_human Homo sapiens A8K932
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 TP53BP2 Homo sapiens Q13625-3
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 TEAD4 Homo sapiens D3DUQ6
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 TEAD4 Homo sapiens D3DUQ6
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 ZNF250 Homo sapiens P15622-3
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 ZNF250 Homo sapiens P15622-3
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 GOLGA8F Homo sapiens Q08AF8
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 GOLGA8F Homo sapiens Q08AF8
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 EIF4A2 Homo sapiens Q14240-2
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 CCDC198 Homo sapiens Q9NVL8
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 CCDC198 Homo sapiens Q9NVL8
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 TBP Homo sapiens Q32MN6
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 TBP Homo sapiens Q32MN6
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 FBF1 Homo sapiens Q8TES7-6
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 FBF1 Homo sapiens Q8TES7-6
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 LATS1 Homo sapiens Q6PJG3
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 LATS1 Homo sapiens Q6PJG3
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 SSX3 Homo sapiens Q99909
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 SSX3 Homo sapiens Q99909
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 SHFL Homo sapiens Q9NUL5
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 SHFL Homo sapiens Q9NUL5
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 POLL Homo sapiens Q9UGP5-2
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 MFAP1 Homo sapiens P55081
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 WRAP73 Homo sapiens Q9P2S5
Anti Tag CoIP
33961781
Intra
SSX2IP Q9Y2D8 WRAP73 Homo sapiens Q9P2S5
Anti Tag CoIP
26638075
Intra
SSX2IP Q9Y2D8 WRAP73 Homo sapiens Q9P2S5
BioID
26638075
Intra
SSX2IP Q9Y2D8 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra
SSX2IP Q9Y2D8 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Cross
SSX2IP Q9Y2D8 Wrap73 Mus musculus Q9JM98
Anti Tag CoIP
26675238
Intra
SSX2IP Q9Y2D8 ZSCAN12 Homo sapiens O43309
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 PRPF31 Homo sapiens Q8WWY3
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 ZNF3 Homo sapiens P17036
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 MOS Homo sapiens P00540
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 MOS Homo sapiens P00540
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 MOS Homo sapiens P00540
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 TRIM54 Homo sapiens Q9BYV2
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 SSX2 Homo sapiens Q16385
Y2H
12007189
Intra
SSX2IP Q9Y2D8 SSX2 Homo sapiens Q16385
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 SSX2 Homo sapiens Q16385
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 SSX2 Homo sapiens Q16385
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 EHHADH Homo sapiens Q08426
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 EHHADH Homo sapiens Q08426
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 FANCL Homo sapiens Q9NW38
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 MRPL53 Homo sapiens Q96EL3
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 PIMREG Homo sapiens Q9BSJ6
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 ZMAT2 Homo sapiens Q96NC0
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 ZMAT2 Homo sapiens Q96NC0
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 ATOSA Homo sapiens Q32MH5
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 ATOSA Homo sapiens Q32MH5
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 YWHAH Homo sapiens Q04917
Anti Tag CoIP
33961781
Intra
SSX2IP Q9Y2D8 ZGPAT Homo sapiens Q8N5A5
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 ABLIM3 Homo sapiens O94929
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 ABLIM3 Homo sapiens O94929
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 BYSL Homo sapiens Q13895
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 BYSL Homo sapiens Q13895
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 BYSL Homo sapiens Q13895
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 PSMA1 Homo sapiens P25786
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 PSMA1 Homo sapiens P25786
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 PSMA1 Homo sapiens P25786
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 TOP3B Homo sapiens O95985
Y2H Array
31515488
Intra
SSX2IP Q9Y2D8 TOP3B Homo sapiens O95985
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 TOP3B Homo sapiens O95985
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 XIAP Homo sapiens P98170
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 XIAP Homo sapiens P98170
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 XIAP Homo sapiens P98170
Y2H Array
31515488
Intra
SSX2IP Q9Y2D8 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 CDCA7L Homo sapiens Q96GN5
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 CDCA7L Homo sapiens Q96GN5
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 WDR5 Homo sapiens P61964
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 PKN1 Homo sapiens Q16512
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 PKN1 Homo sapiens Q16512
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 PKN1 Homo sapiens Q16512
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 ZNF587 Homo sapiens Q96SQ5
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 TTC23 Homo sapiens Q5W5X9
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 ZRSR2 Homo sapiens Q15696
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 INO80B Homo sapiens Q9C086
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 NOL12 Homo sapiens Q9UGY1
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 NOL12 Homo sapiens Q9UGY1
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 FAM161A Homo sapiens Q3B820
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 EIF4A2 Homo sapiens Q14240
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 EIF4A2 Homo sapiens Q14240
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 KRT15 Homo sapiens P19012
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 KLHL42 Homo sapiens Q9P2K6
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 KLHL42 Homo sapiens Q9P2K6
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 KLHL42 Homo sapiens Q9P2K6
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 C11orf54 Homo sapiens Q9H0W9
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 CCNH Homo sapiens P51946
Y2H
21988832
Intra
SSX2IP Q9Y2D8 CCNH Homo sapiens P51946
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 PCM1 Homo sapiens Q15154
IF
24397932
Intra
SSX2IP Q9Y2D8 PCM1 Homo sapiens Q15154
BioID
26638075
Intra
SSX2IP Q9Y2D8 PCM1 Homo sapiens Q15154
Anti Tag CoIP
24397932
Intra
SSX2IP Q9Y2D8 PCM1 Homo sapiens Q15154
Anti Tag CoIP
26638075
Intra
SSX2IP Q9Y2D8 TRIM37 Homo sapiens O94972
BioID
26638075
Intra
SSX2IP Q9Y2D8 FAM124B Homo sapiens Q9H5Z6
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 FAM124B Homo sapiens Q9H5Z6
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 FRMD6 Homo sapiens Q96NE9
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 CHCHD3 Homo sapiens Q9NX63
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 GEM Homo sapiens P55040
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 FNDC11 Homo sapiens Q9BVV2
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 FNDC11 Homo sapiens Q9BVV2
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 FNDC11 Homo sapiens Q9BVV2
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 BEX2 Homo sapiens Q9BXY8
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 BEX2 Homo sapiens Q9BXY8
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 BEX2 Homo sapiens Q9BXY8
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 NAA10 Homo sapiens P41227
Y2H Array
25416956
Intra
SSX2IP Q9Y2D8 CEP55 Homo sapiens Q53EZ4
BioID
26638075
Intra
SSX2IP Q9Y2D8 CEP55 Homo sapiens Q53EZ4
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 SCNM1 Homo sapiens Q9BWG6
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 DAXX Homo sapiens Q9UER7
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 AEN Homo sapiens Q8WTP8
Validated Y2H
25416956
Intra
SSX2IP Q9Y2D8 AEN Homo sapiens Q8WTP8
Y2H Prey Pooling
25416956
Intra
SSX2IP Q9Y2D8 KRT31 Homo sapiens Q15323
Validated Y2H
25416956
Cross
SSX2IP Q9Y2D8 tax Human T-cell leukemia virus P03410
Y2H Array
22458338
Cross
SSX2IP Q9Y2D8 tax Human T-cell leukemia virus P03410
MAPPIT
22458338
Cross
SSX2IP Q9Y2D8 tax Human T-cell leukemia virus P03410
Y2H Pooling
22458338
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Distal Muscular Dystrophy With Anterior Tibial Onset

Dmat
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Epiglottitis

Acute Epiglottitis

Acute Epiglottitis And Supraglottitis

Acute Epiglottiditis

Epiglottiditis

Epiglottitis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13838 SSX2IP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SSX2IP VGNC VGNC:77932
Mus musculus SSX2IP MGD MGI:2139150
Canis familiaris SSX2IP VGNC VGNC:46847
Bos taurus SSX2IP VGNC VGNC:35329
Felis catus SSX2IP VGNC VGNC:65716
Rattus norvegicus SSX2IP RGD RGD:708490