SSX2IP - SSX family member 2 interacting protein Gene

Homo sapiens

Also known as ADIP; hMsd1

Gene ID: 117178 | Gene type: protein coding

About SSX2IP

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:84,643,706-84,690,745 (from NCBI)

This gene has 10 transcripts (splice variants) and 276 orthologues. Broad expression in testis (RPKM 29.1), duodenum (RPKM 14.3) and 19 other tissues.

Summary

This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009]

SSX2IP Products(5)

mRNA	Protein	Name
NM_001166293.2	NP_001159765.1	afadin- and alpha-actinin-binding protein isoform 1
NM_001166294.2	NP_001159766.1	afadin- and alpha-actinin-binding protein isoform 2
NM_001166295.2	NP_001159767.1	afadin- and alpha-actinin-binding protein isoform 2
NM_001166417.2	NP_001159889.1	afadin- and alpha-actinin-binding protein isoform 1
NM_014021.4	NP_054740.3	afadin- and alpha-actinin-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12007189	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	23816619	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	24356449	GOA
involved in intraciliary transport involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	24356449	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriolar satellite	IDA IDA: Inferred from direct assay	23816619	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	24356449	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

afadin- and alpha-actinin-binding protein

SSX2-interacting protein

SSX2IP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SSX2IP	Q9Y2D8	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	a8k932_human	Homo sapiens	A8K932	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	TP53BP2	Homo sapiens	Q13625-3	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	TEAD4	Homo sapiens	D3DUQ6	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	TEAD4	Homo sapiens	D3DUQ6	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	ZNF250	Homo sapiens	P15622-3	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	ZNF250	Homo sapiens	P15622-3	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	GOLGA8F	Homo sapiens	Q08AF8	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	GOLGA8F	Homo sapiens	Q08AF8	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	EIF4A2	Homo sapiens	Q14240-2	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	CCDC198	Homo sapiens	Q9NVL8	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	CCDC198	Homo sapiens	Q9NVL8	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	TBP	Homo sapiens	Q32MN6	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	TBP	Homo sapiens	Q32MN6	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	FBF1	Homo sapiens	Q8TES7-6	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	FBF1	Homo sapiens	Q8TES7-6	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	LATS1	Homo sapiens	Q6PJG3	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	LATS1	Homo sapiens	Q6PJG3	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	SSX3	Homo sapiens	Q99909	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	SSX3	Homo sapiens	Q99909	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	SHFL	Homo sapiens	Q9NUL5	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	SHFL	Homo sapiens	Q9NUL5	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	POLL	Homo sapiens	Q9UGP5-2	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	WRAP73	Homo sapiens	Q9P2S5	Anti Tag CoIP	33961781
Intra	SSX2IP	Q9Y2D8	WRAP73	Homo sapiens	Q9P2S5	Anti Tag CoIP	26638075
Intra	SSX2IP	Q9Y2D8	WRAP73	Homo sapiens	Q9P2S5	BioID	26638075
Intra	SSX2IP	Q9Y2D8	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	SSX2IP	Q9Y2D8	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Cross	SSX2IP	Q9Y2D8	Wrap73	Mus musculus	Q9JM98	Anti Tag CoIP	26675238
Intra	SSX2IP	Q9Y2D8	ZSCAN12	Homo sapiens	O43309	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	PRPF31	Homo sapiens	Q8WWY3	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	ZNF3	Homo sapiens	P17036	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	MOS	Homo sapiens	P00540	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	MOS	Homo sapiens	P00540	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	MOS	Homo sapiens	P00540	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	SSX2	Homo sapiens	Q16385	Y2H	12007189
Intra	SSX2IP	Q9Y2D8	SSX2	Homo sapiens	Q16385	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	SSX2	Homo sapiens	Q16385	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	SSX2	Homo sapiens	Q16385	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	EHHADH	Homo sapiens	Q08426	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	EHHADH	Homo sapiens	Q08426	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	FANCL	Homo sapiens	Q9NW38	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	MRPL53	Homo sapiens	Q96EL3	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	PIMREG	Homo sapiens	Q9BSJ6	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	ZMAT2	Homo sapiens	Q96NC0	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	ZMAT2	Homo sapiens	Q96NC0	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	ATOSA	Homo sapiens	Q32MH5	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	ATOSA	Homo sapiens	Q32MH5	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
Intra	SSX2IP	Q9Y2D8	ZGPAT	Homo sapiens	Q8N5A5	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	ABLIM3	Homo sapiens	O94929	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	ABLIM3	Homo sapiens	O94929	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	BYSL	Homo sapiens	Q13895	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	BYSL	Homo sapiens	Q13895	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	TOP3B	Homo sapiens	O95985	Y2H Array	31515488
Intra	SSX2IP	Q9Y2D8	TOP3B	Homo sapiens	O95985	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	TOP3B	Homo sapiens	O95985	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	XIAP	Homo sapiens	P98170	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	XIAP	Homo sapiens	P98170	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	XIAP	Homo sapiens	P98170	Y2H Array	31515488
Intra	SSX2IP	Q9Y2D8	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	CDCA7L	Homo sapiens	Q96GN5	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	WDR5	Homo sapiens	P61964	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	PKN1	Homo sapiens	Q16512	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	PKN1	Homo sapiens	Q16512	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	PKN1	Homo sapiens	Q16512	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	ZNF587	Homo sapiens	Q96SQ5	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	TTC23	Homo sapiens	Q5W5X9	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	ZRSR2	Homo sapiens	Q15696	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	INO80B	Homo sapiens	Q9C086	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	NOL12	Homo sapiens	Q9UGY1	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	NOL12	Homo sapiens	Q9UGY1	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	EIF4A2	Homo sapiens	Q14240	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	EIF4A2	Homo sapiens	Q14240	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	LMO2	Homo sapiens	P25791	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	KLHL42	Homo sapiens	Q9P2K6	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	KLHL42	Homo sapiens	Q9P2K6	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	KLHL42	Homo sapiens	Q9P2K6	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	C11orf54	Homo sapiens	Q9H0W9	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	CCNH	Homo sapiens	P51946	Y2H	21988832
Intra	SSX2IP	Q9Y2D8	CCNH	Homo sapiens	P51946	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	PCM1	Homo sapiens	Q15154	IF	24397932
Intra	SSX2IP	Q9Y2D8	PCM1	Homo sapiens	Q15154	BioID	26638075
Intra	SSX2IP	Q9Y2D8	PCM1	Homo sapiens	Q15154	Anti Tag CoIP	24397932
Intra	SSX2IP	Q9Y2D8	PCM1	Homo sapiens	Q15154	Anti Tag CoIP	26638075
Intra	SSX2IP	Q9Y2D8	TRIM37	Homo sapiens	O94972	BioID	26638075
Intra	SSX2IP	Q9Y2D8	FAM124B	Homo sapiens	Q9H5Z6	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	FAM124B	Homo sapiens	Q9H5Z6	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	FRMD6	Homo sapiens	Q96NE9	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	CHCHD3	Homo sapiens	Q9NX63	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	GEM	Homo sapiens	P55040	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	FNDC11	Homo sapiens	Q9BVV2	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	FNDC11	Homo sapiens	Q9BVV2	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	FNDC11	Homo sapiens	Q9BVV2	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	BEX2	Homo sapiens	Q9BXY8	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	BEX2	Homo sapiens	Q9BXY8	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	NAA10	Homo sapiens	P41227	Y2H Array	25416956
Intra	SSX2IP	Q9Y2D8	CEP55	Homo sapiens	Q53EZ4	BioID	26638075
Intra	SSX2IP	Q9Y2D8	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	SCNM1	Homo sapiens	Q9BWG6	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	DAXX	Homo sapiens	Q9UER7	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	AEN	Homo sapiens	Q8WTP8	Validated Y2H	25416956
Intra	SSX2IP	Q9Y2D8	AEN	Homo sapiens	Q8WTP8	Y2H Prey Pooling	25416956
Intra	SSX2IP	Q9Y2D8	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Cross	SSX2IP	Q9Y2D8	tax	Human T-cell leukemia virus	P03410	Y2H Array	22458338
Cross	SSX2IP	Q9Y2D8	tax	Human T-cell leukemia virus	P03410	MAPPIT	22458338
Cross	SSX2IP	Q9Y2D8	tax	Human T-cell leukemia virus	P03410	Y2H Pooling	22458338

Cross: Cross-species interaction Intra: Intraspecies interaction

SSX2IP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82320	SSX2IP Antibody (YA2065)	WB, IHC-F, IHC-P, ICC/IF	Human, Rat

Related Diseases

Diseases

Alias

Distal Muscular Dystrophy With Anterior Tibial Onset

Dmat

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Epiglottitis

Acute Epiglottitis	Acute Epiglottitis And Supraglottitis
Acute Epiglottiditis	Epiglottiditis
Epiglottitis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13838	SSX2IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SSX2IP	VGNC	VGNC:77932
Mus musculus	SSX2IP	MGD	MGI:2139150
Canis familiaris	SSX2IP	VGNC	VGNC:46847
Bos taurus	SSX2IP	VGNC	VGNC:35329
Felis catus	SSX2IP	VGNC	VGNC:65716
Rattus norvegicus	SSX2IP	RGD	RGD:708490

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