SSX2IP - SSX family member 2 interacting protein Gene

Homo sapiens

Also known as ADIP; hMsd1

Gene ID: 117178 | Gene type: protein coding

About SSX2IP

Cytogenetic location: 1p22.3 Genomic coordinates (GRCh38): 1:84,643,706-84,690,745 (from NCBI)

This gene has 10 transcripts (splice variants) and 276 orthologues. Broad expression in testis (RPKM 29.1), duodenum (RPKM 14.3) and 19 other tissues.

Summary

This gene encodes a protein that binds the cancer-testis antigen Synovial Sarcoma X breakpoint 2 protein. The encoded protein may regulate the activity of Synovial Sarcoma X breakpoint 2 protein in malignant cells. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Oct 2009]

SSX2IP Products(5)

mRNA	Protein	Name
NM_001166293.2	NP_001159765.1	afadin- and alpha-actinin-binding protein isoform 1
NM_001166294.2	NP_001159766.1	afadin- and alpha-actinin-binding protein isoform 2
NM_001166295.2	NP_001159767.1	afadin- and alpha-actinin-binding protein isoform 2
NM_001166417.2	NP_001159889.1	afadin- and alpha-actinin-binding protein isoform 1
NM_014021.4	NP_054740.3	afadin- and alpha-actinin-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12007189	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	23816619	GOA
involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	24356449	GOA
involved in intraciliary transport involved in cilium assembly	IMP IMP: Inferred from mutant phenotype	24356449	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centriolar satellite	IDA IDA: Inferred from direct assay	23816619	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	24356449	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

afadin- and alpha-actinin-binding protein

SSX2-interacting protein

Related Diseases

Diseases

Alias

Distal Muscular Dystrophy With Anterior Tibial Onset

Dmat

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Epiglottitis

Acute Epiglottitis	Acute Epiglottitis And Supraglottitis
Acute Epiglottiditis	Epiglottiditis
Epiglottitis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13838	SSX2IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SSX2IP	VGNC	VGNC:77932
Mus musculus	SSX2IP	MGD	MGI:2139150
Canis familiaris	SSX2IP	VGNC	VGNC:46847
Bos taurus	SSX2IP	VGNC	VGNC:35329
Felis catus	SSX2IP	VGNC	VGNC:65716
Rattus norvegicus	SSX2IP	RGD	RGD:708490

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