1. Gene
  2. ARHGEF15 - Rho guanine nucleotide exchange factor 15 Gene

ARHGEF15 - Rho guanine nucleotide exchange factor 15 Gene

Homo sapiens

Also known as E5; ARGEF15; Ephexin5; Vsm-RhoGEF

Gene ID: 22899 | Gene type: protein coding

About ARHGEF15

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,310,241-8,322,511 (from NCBI)

This gene has 9 transcripts (splice variants), 213 orthologues and 6 paralogues. Broad expression in fat (RPKM 15.9), lung (RPKM 13.8) and 19 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

ARHGEF15 Products(2)

mRNA Protein Name
NM_025014.2 NP_079290.1 rho guanine nucleotide exchange factor 15
NM_173728.4 NP_776089.2 rho guanine nucleotide exchange factor 15
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
12775584 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12775584 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of catalytic activity IDA
IDA: Inferred from direct assay
12775584 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF15 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (422 - 598)

  • 0
  • 200
  • 400
  • 600
  • 841 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 15

Rho guanine nucleotide exchange factor (GEF) 15

ARHGEF15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ARHGEF15 O94989 PRKG1 Homo sapiens Q13976-2
Validated Y2H
32296183
Intra
ARHGEF15 O94989 PIN1 Homo sapiens Q13526
Y2H Array
25416956
Intra
ARHGEF15 O94989 PIN1 Homo sapiens Q13526
Y2H Prey Pooling
25416956
Intra
ARHGEF15 O94989 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
ARHGEF15 O94989 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
ARHGEF15 O94989 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Y2H Array
26871637
Intra
ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Y2H Array
32296183
Intra
ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Validated Y2H
26871637
Intra
ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Validated Y2H
32296183
Intra
ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
25416956
Intra
ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
26871637
Intra
ARHGEF15 O94989 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Ohtahara Syndrome
Spastic Ataxia, Charlevoix-Saguenay Type

Charlevoix-Saguenay Spastic Ataxia

Autosomal Recessive Spastic Ataxia Of Charlevoix-Saguenay

Arsacs

SACS

Spax6

Spastic Ataxia Charlevoix-Saguenay Type

Spastic Ataxia 6, Autosomal Recessive

Autosomal Recessive Spastic Ataxia Type 6

Spastic Ataxia Of Charlevoix-Saguenay

Atx/Hsp-Sacs

Ataxia, Spastic, Charlevoix-Saguenay Type

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile

Hypophosphatasia, Childhood

Childhood Hypophosphatasia

Childhood-Onset Hypophosphatasia

HPPC

Childhood-Onset Phosphoethanolaminuria

Childhood-Onset Rathburn Disease

Childhood-Onset Rathbun Disease

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris ARHGEF15 VGNC VGNC:38076
Macaca mulatta ARHGEF15 VGNC VGNC:69832
Rattus norvegicus ARHGEF15 RGD RGD:1306961
Bos taurus ARHGEF15 VGNC VGNC:26107
Mus musculus ARHGEF15 MGD MGI:3045246
Felis catus ARHGEF15 VGNC VGNC:59900