CEP55 - centrosomal protein 55 Gene

Homo sapiens

Also known as CT111; MARCH; URCC6; C10orf3

Gene ID: 55165 | Gene type: protein coding

About CEP55

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:93,496,612-93,529,092 (from NCBI)

This gene has 3 transcripts (splice variants), 234 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 13.8), lymph node (RPKM 8.3) and 14 other tissues.

Summary

Enables identical protein binding activity. Involved in cranial skeletal system development; establishment of protein localization; and midbody abscission. Acts upstream of or within mitotic cytokinesis. Located in Flemming body; centriolar satellite; and plasma membrane. Implicated in multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia and hydranencephaly. [provided by Alliance of Genome Resources, Apr 2022]

CEP55 Products(2)

mRNA	Protein	Name
NM_001127182.2	NP_001120654.2	centrosomal protein of 55 kDa
NM_018131.5	NP_060601.4	centrosomal protein of 55 kDa

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	17853893	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cranial skeletal system development	IMP IMP: Inferred from mutant phenotype	28264986	GOA
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23045692	GOA
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	20616062	GOA
acts upstream of or within mitotic cytokinesis	IGI IGI: Inferred from genetic interaction	19638580	GOA
NOT involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20616062	GOA
NOT involved in nucleus organization	IMP IMP: Inferred from mutant phenotype	20616062	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Flemming body	IDA IDA: Inferred from direct assay	18641129	GOA
located in centrosome	IDA IDA: Inferred from direct assay	20186884	GOA
located in midbody	IDA IDA: Inferred from direct assay	20186884	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEP55 Protein Structure

EABR

0
100
200
300
400
464 a.a.

Protein Preferred Names

Protein Names

centrosomal protein of 55 kDa

cancer/testis antigen 111

CEP55 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CEP55	Q53EZ4	a8k9c1_human	Homo sapiens	A8K9C1	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	a8k9c1_human	Homo sapiens	A8K9C1	Y2H Array	25416956
Intra	CEP55	Q53EZ4	a8k9c1_human	Homo sapiens	A8K9C1	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	TEAD4	Homo sapiens	D3DUQ6	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Array	25416956
Intra	CEP55	Q53EZ4	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	PWWP3A	Homo sapiens	Q2TAK8-2	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	PWWP3A	Homo sapiens	Q2TAK8-2	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	PLEKHG6	Homo sapiens	Q3KR16	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	PLEKHG6	Homo sapiens	Q3KR16	Y2H Array	31515488
Intra	CEP55	Q53EZ4	PLEKHG6	Homo sapiens	Q3KR16	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	PLEKHG6	Homo sapiens	Q3KR16	Y2H Array	25416956
Intra	CEP55	Q53EZ4	FBF1	Homo sapiens	Q8TES7-6	Y2H Array	25416956
Intra	CEP55	Q53EZ4	FBF1	Homo sapiens	Q8TES7-6	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	MIA3	Homo sapiens	Q5JRA6-2	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	MIA3	Homo sapiens	Q5JRA6-2	MAPPIT	25416956
Intra	CEP55	Q53EZ4	MIA3	Homo sapiens	Q5JRA6-2	Y2H Array	25416956
Intra	CEP55	Q53EZ4	ANXA11	Homo sapiens	Q5T0G8	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	ANXA11	Homo sapiens	Q5T0G8	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	POLM	Homo sapiens	Q6PIY2	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	POLM	Homo sapiens	Q6PIY2	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	POLM	Homo sapiens	Q6PIY2	Y2H Array	25416956
Intra	CEP55	Q53EZ4	PPP1R16B	Homo sapiens	Q96T49	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	PPP1R16B	Homo sapiens	Q96T49	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	MFAP1	Homo sapiens	P55081	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	MFAP1	Homo sapiens	P55081	Y2H Array	25416956
Intra	CEP55	Q53EZ4	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	CEP55	Q53EZ4	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	CEP55	Q53EZ4	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	CEP55	Q53EZ4	CEP57L1	Homo sapiens	Q8IYX8	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	CEP57L1	Homo sapiens	Q8IYX8	Y2H	21516116
Intra	CEP55	Q53EZ4	CEP57L1	Homo sapiens	Q8IYX8	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	CBY2	Homo sapiens	Q8NA61-2	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	TP53BP2	Homo sapiens	Q05BL1	Y2H Prey Pooling	32296183
Intra	CEP55	Q53EZ4	TP53BP2	Homo sapiens	Q05BL1	Y2H Array	32296183
Intra	CEP55	Q53EZ4	ZNF48	Homo sapiens	Q96MX3	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	CCBE1	Homo sapiens	Q6UXH8-3	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	KIFC3	Homo sapiens	Q9BVG8	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Array	25416956
Intra	CEP55	Q53EZ4	SSX2IP	Homo sapiens	Q9Y2D8	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	VPS37C	Homo sapiens	A5D8V6	Affinity Chrom	17853893
Intra	CEP55	Q53EZ4	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	CEP55	Q53EZ4	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	CEP55	Q53EZ4	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	CEP55	Q53EZ4	RBM22	Homo sapiens	Q9NW64	Y2H Array	25416956
Intra	CEP55	Q53EZ4	RBM22	Homo sapiens	Q9NW64	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	RBM22	Homo sapiens	Q9NW64	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	TPP1	Homo sapiens	O14773	Validated Y2H	32814053
Intra	CEP55	Q53EZ4	TPP1	Homo sapiens	O14773	Y2H Array	32814053
Intra	CEP55	Q53EZ4	TPP1	Homo sapiens	O14773	Y2H Pooling	32814053
Intra	CEP55	Q53EZ4	PDCD6IP	Homo sapiens	Q8WUM4	Y2H Array	31515488
Intra	CEP55	Q53EZ4	PDCD6IP	Homo sapiens	Q8WUM4	Anti Tag CoIP	17853893
Intra	CEP55	Q53EZ4	PDCD6IP	Homo sapiens	Q8WUM4	Gal4 VP16 Complement	20176808
Intra	CEP55	Q53EZ4	PDCD6IP	Homo sapiens	Q8WUM4	Y2H	17853893
Intra	CEP55	Q53EZ4	PDCD6IP	Homo sapiens	Q8WUM4	Affinity Chrom	17853893
Intra	CEP55	Q53EZ4	PDCD6IP	Homo sapiens	Q8WUM4	FPS	37100772
Intra	CEP55	Q53EZ4	TSG101	Homo sapiens	Q99816	Affinity Chrom	17853893
Intra	CEP55	Q53EZ4	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	TSG101	Homo sapiens	Q99816	MAPPIT	25416956
Intra	CEP55	Q53EZ4	TSG101	Homo sapiens	Q99816	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	17853893
Intra	CEP55	Q53EZ4	TSG101	Homo sapiens	Q99816	Validated Y2H	27107012
Intra	CEP55	Q53EZ4	TSG101	Homo sapiens	Q99816	Y2H	17853893
Intra	CEP55	Q53EZ4	TSG101	Homo sapiens	Q99816	Gal4 VP16 Complement	20176808
Intra	CEP55	Q53EZ4	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	33961781
Intra	CEP55	Q53EZ4	TFG	Homo sapiens	Q92734	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	TFG	Homo sapiens	Q92734	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	TFG	Homo sapiens	Q92734	Y2H Array	25416956
Intra	CEP55	Q53EZ4	TFG	Homo sapiens	Q92734	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	CDC45	Homo sapiens	O75419	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	CDC45	Homo sapiens	O75419	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	CCBE1	Homo sapiens	Q6UXH8	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	SNW1	Homo sapiens	Q13573	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	SNW1	Homo sapiens	Q13573	Y2H Array	25416956
Intra	CEP55	Q53EZ4	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	TEX14	Homo sapiens	Q8IWB6	Y2H	20176808
Intra	CEP55	Q53EZ4	TEX14	Homo sapiens	Q8IWB6	Gal4 VP16 Complement	20176808
Intra	CEP55	Q53EZ4	TEX14	Homo sapiens	Q8IWB6	FPS	37100772
Intra	CEP55	Q53EZ4	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	WASHC3	Homo sapiens	Q9Y3C0	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	ANXA11	Homo sapiens	P50995	Y2H Array	31515488
Intra	CEP55	Q53EZ4	FAM161B	Homo sapiens	Q96MY7	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	PTPN23	Homo sapiens	Q9H3S7	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	CEP55	Q53EZ4	HGS	Homo sapiens	O14964	Y2H	17853893
Intra	CEP55	Q53EZ4	RBM17	Homo sapiens	Q96I25	Y2H Array	31515488
Intra	CEP55	Q53EZ4	RBM17	Homo sapiens	Q96I25	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	RBM17	Homo sapiens	Q96I25	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	RBM17	Homo sapiens	Q96I25	Y2H Array	25416956
Intra	CEP55	Q53EZ4	RBM17	Homo sapiens	Q96I25	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	FXR2	Homo sapiens	P51116	Y2H Array	25416956
Intra	CEP55	Q53EZ4	ARHGEF15	Homo sapiens	O94989	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	ARHGEF15	Homo sapiens	O94989	Y2H Array	25416956
Intra	CEP55	Q53EZ4	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	MAPK1IP1L	Homo sapiens	Q8NDC0	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	RCOR3	Homo sapiens	Q9P2K3	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	RCOR3	Homo sapiens	Q9P2K3	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	CCDC120	Homo sapiens	Q96HB5	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	CARF	Homo sapiens	Q8N187	Validated Y2H	32814053
Intra	CEP55	Q53EZ4	CARF	Homo sapiens	Q8N187	Y2H Array	32814053
Intra	CEP55	Q53EZ4	CARF	Homo sapiens	Q8N187	Y2H Pooling	32814053
Intra	CEP55	Q53EZ4	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	CEP55	Q53EZ4	TCL1A	Homo sapiens	P56279	Validated Y2H	27107012
Intra	CEP55	Q53EZ4	TCL1A	Homo sapiens	P56279	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	EIF1AD	Homo sapiens	Q8N9N8	Y2H Array	31515488
Intra	CEP55	Q53EZ4	EIF1AD	Homo sapiens	Q8N9N8	Y2H Prey Pooling	25416956
Intra	CEP55	Q53EZ4	EIF1AD	Homo sapiens	Q8N9N8	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	25416956
Intra	CEP55	Q53EZ4	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly

MARCH	Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia And Hydranencephaly
Multinucleated Neurons-Anhydramnios-Renal Dysplasia-Cerebellar Hypoplasia-Hydranencephaly Syndrome	Hydranencephaly With Renal Aplasia-Dysplasia
March Syndrome

Hydranencephaly

Hydroanencephaly

Renal Dysplasia

Kidney Dysplasia	Renal Cell Dysplasia
Congenital Renal Dysplasia	Dysplasia Of Kidney
Dysplastic Kidney

Cerebellar Hypoplasia

Hyperinsulinemic Hypoglycemia, Familial, 1

HHF1	Persistent Hyperinsulinemic Hypoglycemia Of Infancy
Familial Hyperinsulinemic Hypoglycemia 1	Congenital Hyperinsulinism
Phhi	Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Of Infancy	Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia
Nesidioblastosis Of Pancreas	Hyperinsulinism, Familial, With Pancreatic Nesidioblastosis
Hyperinsulinism, Congenital	Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Diazoxide-Resistant Focal Hyperinsulinism Due To Sur1 Deficiency	Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency, Diazoxide-Resistant Focal Form
Autosomal Recessive Hyperinsulinism Due To Sur1 Deficiency	Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Sur1 Deficiency
Hypoglycemia, Hyperinsulinemic, Familial, Type 1

Hyperinsulinemic Hypoglycemia, Familial, 4

Hyperinsulinism Due To Glutamodehydrogenase Deficiency	HHF4
Familial Hyperinsulinemic Hypoglycemia 4	Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Hyperinsulinism Due To Schad Deficiency	Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Congenital Hyperinsulinism	Schad Deficiency
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
3-Hydroxyacyl-Coa Dehydrogenase Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02517	CEP55 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CEP55	VGNC	VGNC:60776
Macaca mulatta	CEP55	VGNC	VGNC:70935
Bos taurus	CEP55	VGNC	VGNC:27206
Rattus norvegicus	CEP55	RGD	RGD:1305340
Mus musculus	CEP55	MGD	MGI:1921357
Canis familiaris	CEP55	VGNC	VGNC:39130
Others	CEP55	NCBI

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