RUFY3 - RUN and FYVE domain containing 3 Gene

Homo sapiens

Also known as RIPX; SINGAR1; ZFYVE30

Gene ID: 22902 | Gene type: protein coding

About RUFY3

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,703,767-70,808,619 (from NCBI)

This gene has 15 transcripts (splice variants), 215 orthologues and 13 paralogues. Ubiquitous expression in brain (RPKM 27.2), testis (RPKM 10.8) and 24 other tissues.

Summary

This gene encodes a RPIP8, UNC-14, and NESCA domain-containing protein that is required for maintenance of neuronal polarity. In addition, it has been implicated in mediation of gastric Cancer cell migration and invasion via interaction with P21-activated kinase-1, which promotes its expression. The encoded protein localizes to F-actin-enriched invadopodia to induce formation of protrusions, thereby facilitating cell migration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

RUFY3 Products(6)

mRNA	Protein	Name
NM_001037442.4	NP_001032519.1	protein RUFY3 isoform 1
NM_001130709.2	NP_001124181.1	protein RUFY3 isoform 3
NM_001291993.2	NP_001278922.1	protein RUFY3 isoform 4
NM_001291994.2	NP_001278923.1	protein RUFY3 isoform 5
NM_001345840.2	NP_001332769.1	protein RUFY3 isoform 6
NM_014961.5	NP_055776.1	protein RUFY3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25766321	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	25766321	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25766321	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RUFY3 Protein Structure

RUN

0
100
200
300
400
469 a.a.

Protein Preferred Names

Protein Names

protein RUFY3

rap2 interacting protein x

RUFY3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RUFY3	Q7L099	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12345	RUFY3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RUFY3	VGNC	VGNC:45805
Macaca mulatta	RUFY3	VGNC	VGNC:77128
Bos taurus	RUFY3	VGNC	VGNC:34215
Rattus norvegicus	RUFY3	RGD	RGD:1565242
Mus musculus	RUFY3	MGD	MGI:106484
Felis catus	RUFY3	VGNC	VGNC:64820

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