ABI3 - ABI family member 3 Gene

Homo sapiens

Also known as NESH; SSH3BP3

Gene ID: 51225 | Gene type: protein coding

About ABI3

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:49,210,707-49,223,225 (from NCBI)

This gene has 4 transcripts (splice variants), 181 orthologues and 2 paralogues. Broad expression in spleen (RPKM 23.3), lymph node (RPKM 10.1) and 21 other tissues.

Summary

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ABI3 Products(2)

mRNA	Protein	Name
NM_001135186.2	NP_001128658.2	ABI gene family member 3 isoform 2
NM_016428.3	NP_057512.2	ABI gene family member 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to tumor cell	IMP IMP: Inferred from mutant phenotype	21223585	GOA
NOT acts upstream of or within peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	17101133	GOA
involved in positive regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	21223585	GOA
acts upstream of or within regulation of cell migration	IDA IDA: Inferred from direct assay	11956071	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SCAR complex	IDA IDA: Inferred from direct assay	17101133	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	17101133	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABI3 Protein Structure

Abi_HHR

SH3_9

0
100
200
300
366 a.a.

Protein Preferred Names

Protein Names

ABI gene family member 3

new molecule including SH3

ABI3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ABI3	Q9P2A4	KRT13	Homo sapiens	A1A4E9	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	b2r8y4_human	Homo sapiens	B2R8Y4	Y2H Array	25416956
Intra	ABI3	Q9P2A4	EIF3S3	Homo sapiens	Q6IB98	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	EIF3S3	Homo sapiens	Q6IB98	Y2H Array	25416956
Intra	ABI3	Q9P2A4	EIF3S3	Homo sapiens	Q6IB98	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	FBF1	Homo sapiens	Q8TES7-6	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	FBF1	Homo sapiens	Q8TES7-6	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	FBF1	Homo sapiens	Q8TES7-6	Y2H Array	25416956
Intra	ABI3	Q9P2A4	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	ABI3	Q9P2A4	KRT35	Homo sapiens	Q92764	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	KRT35	Homo sapiens	Q92764	Y2H Array	32296183
Intra	ABI3	Q9P2A4	MIS18A	Homo sapiens	Q9NYP9	Y2H Array	32296183
Intra	ABI3	Q9P2A4	MIS18A	Homo sapiens	Q9NYP9	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	GNG13	Homo sapiens	Q9P2W3	Validated Y2H	32296183
Intra	ABI3	Q9P2A4	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	ABI3	Q9P2A4	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Array	32296183
Intra	ABI3	Q9P2A4	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	ABI3	Q9P2A4	KRT36	Homo sapiens	O76013-2	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	KRT36	Homo sapiens	O76013-2	Y2H Array	32296183
Intra	ABI3	Q9P2A4	KRT28	Homo sapiens	Q7Z3Y7	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	KRT28	Homo sapiens	Q7Z3Y7	Y2H Array	32296183
Intra	ABI3	Q9P2A4	WASF1	Homo sapiens	Q92558	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	WASF1	Homo sapiens	Q92558	Y2H Array	32296183
Intra	ABI3	Q9P2A4	CENPQ	Homo sapiens	Q7L2Z9	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	CENPQ	Homo sapiens	Q7L2Z9	Y2H Array	32296183
Intra	ABI3	Q9P2A4	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	KANK2	Homo sapiens	Q63ZY3	Y2H Array	25416956
Intra	ABI3	Q9P2A4	DESI1	Homo sapiens	Q6ICB0	Y2H Array	32296183
Intra	ABI3	Q9P2A4	DESI1	Homo sapiens	Q6ICB0	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	NUP58	Homo sapiens	Q9BVL2	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	NUP58	Homo sapiens	Q9BVL2	Y2H	21516116
Intra	ABI3	Q9P2A4	NUP58	Homo sapiens	Q9BVL2	Y2H Array	25416956
Intra	ABI3	Q9P2A4	KRT24	Homo sapiens	Q2M2I5	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	KRT24	Homo sapiens	Q2M2I5	Y2H Array	32296183
Intra	ABI3	Q9P2A4	WAS	Homo sapiens	P42768	Y2H Array	25416956
Intra	ABI3	Q9P2A4	EVL	Homo sapiens	Q9UI08	Y2H Array	29892012
Intra	ABI3	Q9P2A4	EVL	Homo sapiens	Q9UI08	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	EVL	Homo sapiens	Q9UI08	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	SH3BP1	Homo sapiens	Q9Y3L3	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	SH3BP1	Homo sapiens	Q9Y3L3	Validated Y2H	32296183
Intra	ABI3	Q9P2A4	SH3BP1	Homo sapiens	Q9Y3L3	Y2H Array	32296183
Intra	ABI3	Q9P2A4	EIF3M	Homo sapiens	Q7L2H7	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	EIF3M	Homo sapiens	Q7L2H7	Y2H Array	32296183
Intra	ABI3	Q9P2A4	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	ABI3	Q9P2A4	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	MED29	Homo sapiens	Q9NX70	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	MED29	Homo sapiens	Q9NX70	Y2H Array	32296183
Intra	ABI3	Q9P2A4	GRB2	Homo sapiens	P62993	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	GRB2	Homo sapiens	P62993	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	GRB2	Homo sapiens	P62993	Y2H Array	25416956
Intra	ABI3	Q9P2A4	BLOC1S5	Homo sapiens	Q8TDH9	Y2H Array	32296183
Intra	ABI3	Q9P2A4	BLOC1S5	Homo sapiens	Q8TDH9	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	OIP5	Homo sapiens	O43482	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	OIP5	Homo sapiens	O43482	Y2H Array	32296183
Intra	ABI3	Q9P2A4	EVL	Homo sapiens	Q9UI08-2	Validated Y2H	32296183
Intra	ABI3	Q9P2A4	KRT14	Homo sapiens	P02533	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	KRT14	Homo sapiens	P02533	Y2H Array	32296183
Intra	ABI3	Q9P2A4	EIF3H	Homo sapiens	O15372	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	EIF3H	Homo sapiens	O15372	Y2H Array	19060904
Intra	ABI3	Q9P2A4	EIF3H	Homo sapiens	O15372	Y2H Pooling	19060904
Intra	ABI3	Q9P2A4	EIF3H	Homo sapiens	O15372	Y2H Array	32296183
Intra	ABI3	Q9P2A4	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	ABI3	Q9P2A4	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	ABI3	Q9P2A4	NCK2	Homo sapiens	O43639	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	RUFY3	Homo sapiens	Q7L099	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	RUFY3	Homo sapiens	Q7L099	Y2H Array	32296183
Intra	ABI3	Q9P2A4	FARSA	Homo sapiens	Q9Y285	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	FARSA	Homo sapiens	Q9Y285	Y2H Array	25416956
Intra	ABI3	Q9P2A4	KIAA0408	Homo sapiens	Q6ZU52	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	KIAA0408	Homo sapiens	Q6ZU52	Y2H Array	32296183
Intra	ABI3	Q9P2A4	SUFU	Homo sapiens	Q9UMX1	Validated Y2H	32296183
Intra	ABI3	Q9P2A4	CEP44	Homo sapiens	Q9C0F1	Y2H Array	32296183
Intra	ABI3	Q9P2A4	CEP44	Homo sapiens	Q9C0F1	Y2H Pooling	16189514
Intra	ABI3	Q9P2A4	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	ABI3	Q9P2A4	ARMC7	Homo sapiens	Q9H6L4	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	ARMC7	Homo sapiens	Q9H6L4	Y2H Array	25416956
Intra	ABI3	Q9P2A4	HOMER1	Homo sapiens	Q86YM7	Y2H Array	32296183
Intra	ABI3	Q9P2A4	HOMER1	Homo sapiens	Q86YM7	Y2H Pooling	16189514
Intra	ABI3	Q9P2A4	HOMER1	Homo sapiens	Q86YM7	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	VASP	Homo sapiens	P50552	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	VASP	Homo sapiens	P50552	Y2H Array	32296183
Intra	ABI3	Q9P2A4	VASP	Homo sapiens	P50552	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	VASP	Homo sapiens	P50552	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	MAGEA12	Homo sapiens	P43365	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	MAGEA12	Homo sapiens	P43365	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	IHO1	Homo sapiens	Q8IYA8	Y2H Array	32296183
Intra	ABI3	Q9P2A4	IHO1	Homo sapiens	Q8IYA8	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	IFT20	Homo sapiens	Q8IY31-3	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32296183
Intra	ABI3	Q9P2A4	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	NDEL1	Homo sapiens	Q9GZM8	Y2H Array	32296183
Intra	ABI3	Q9P2A4	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	ABI3	Q9P2A4	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	KLC4	Homo sapiens	Q9NSK0	Y2H Array	25416956
Intra	ABI3	Q9P2A4	KLC4	Homo sapiens	Q9NSK0	Y2H Prey Pooling	25416956
Intra	ABI3	Q9P2A4	KLC4	Homo sapiens	Q9NSK0	Validated Y2H	25416956
Intra	ABI3	Q9P2A4	MRFAP1	Homo sapiens	Q9Y605	Y2H Prey Pooling	32296183
Intra	ABI3	Q9P2A4	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	32296183
Intra	ABI3	Q9P2A4	MRFAP1	Homo sapiens	Q9Y605	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1

Nasu-Hakola Disease	Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
Plosl	Nhd
Presenile Dementia With Bone Cysts	Plo-Sl
PLOSL1	Dementia, Prefrontal, With Bone Cysts
Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease
Progressive Dementia With Lipomembranous Polycystic Osteodysplasia	Brain-Bone-Fat Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00101	ABI3BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00100	ABI3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ABI3	RGD	RGD:1311794
Bos taurus	ABI3	VGNC	VGNC:25507
Mus musculus	ABI3	MGD	MGI:1913860
Felis catus	ABI3	VGNC	VGNC:59488
Macaca mulatta	ABI3	VGNC	VGNC:69549
Canis familiaris	ABI3	VGNC	VGNC:37476

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