KIFAP3 - kinesin associated protein 3 Gene

Homo sapiens

Also known as FLA3; KAP3; SMAP; KAP-1; KAP-3; Smg-GDS; dJ190I16.1

Gene ID: 22920 | Gene type: protein coding

About KIFAP3

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:169,921,329-170,085,184 (from NCBI)

This gene has 6 transcripts (splice variants) and 260 orthologues. Broad expression in brain (RPKM 27.3), testis (RPKM 15.2) and 24 other tissues.

Summary

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a Kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

KIFAP3 Products(6)

mRNA	Protein	Name
NM_001204514.2	NP_001191443.1	kinesin-associated protein 3 isoform 2
NM_001204516.2	NP_001191445.1	kinesin-associated protein 3 isoform 3
NM_001204517.2	NP_001191446.1	kinesin-associated protein 3 isoform 4
NM_001375830.1	NP_001362759.1	kinesin-associated protein 3 isoform 5
NM_001375831.1	NP_001362760.1	kinesin-associated protein 3 isoform 6
NM_014970.4	NP_055785.2	kinesin-associated protein 3 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinesin binding	IPI IPI: Inferred from physical interaction	16298999	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9506951	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	24338362	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	16298999	GOA
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	16298999	GOA
part of kinesin II complex	IDA IDA: Inferred from direct assay	16298999	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	16298999	GOA
colocalizes with spindle microtubule	IDA IDA: Inferred from direct assay	16298999	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIFAP3 Protein Structure

KAP

0
200
400
600
792 a.a.

Protein Preferred Names

Protein Names

kinesin-associated protein 3

small G protein GDP dissociation stimulator

KIFAP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KIFAP3	Q92845	KIF3A	Homo sapiens	Q9Y496	Anti Bait CoIP	16298999
Intra	KIFAP3	Q92845	KIF3A	Homo sapiens	Q9Y496	Anti Tag CoIP	33961781
Intra	KIFAP3	Q92845	KIF3A	Homo sapiens	Q9Y496	TAP	27173435
Intra	KIFAP3	Q92845	KIF3A	Homo sapiens	Q9Y496	Anti Tag CoIP	26496610
Intra	KIFAP3	Q92845	KIF3A	Homo sapiens	Q9Y496	Anti Tag CoIP	28514442
Intra	KIFAP3	Q92845	C19orf44	Homo sapiens	Q9H6X5-2	Validated Y2H	32296183
Intra	KIFAP3	Q92845	NAA11	Homo sapiens	Q9BSU3	Validated Y2H	32296183
Intra	KIFAP3	Q92845	KIF3B	Homo sapiens	O15066	Anti Tag CoIP	33961781
Intra	KIFAP3	Q92845	KIF3B	Homo sapiens	O15066	Anti Bait CoIP	16298999
Intra	KIFAP3	Q92845	KIF3B	Homo sapiens	O15066	TAP	27173435
Intra	KIFAP3	Q92845	KIF3B	Homo sapiens	O15066	Anti Tag CoIP	28514442
Intra	KIFAP3	Q92845	KIF3B	Homo sapiens	O15066	Anti Tag CoIP	26496610
Intra	KIFAP3	Q92845	NCF2	Homo sapiens	P19878	Y2H Array	31515488
Intra	KIFAP3	Q92845	NAA10	Homo sapiens	P41227	Validated Y2H	25416956
Intra	KIFAP3	Q92845	NAA10	Homo sapiens	P41227	Y2H Array	25416956
Intra	KIFAP3	Q92845	NAA10	Homo sapiens	P41227	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Lipoma

Lipoma Of Breast

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy	Jeune Syndrome
Asphyxiating Thoracic Dysplasia	Short-Rib Thoracic Dysplasia With Or Without Polydactyly
Thoracic Pelvic Phalangeal Dystrophy	Asphyxiating Thoracic Chondrodystrophy
Atd	Chondroectodermal Dysplasia-Like Syndrome
Infantile Thoracic Dystrophy	Jeune Thoracic Dysplasia
Thoracic Asphyxiant Dystrophy	Thoracic-Pelvic-Phalangeal Dystrophy
Short-Rib Thoracic Dysplasia Without Polydactyly	Asphyxiating Thoracic Dystrophy Of The Newborn
Asphyxiating Thorax Dystrophy

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07297	KIFAP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIFAP3	MGD	MGI:107566
Canis familiaris	KIFAP3	VGNC	VGNC:42413
Felis catus	KIFAP3	VGNC	VGNC:63120
Rattus norvegicus	KIFAP3	RGD	RGD:1305191
Macaca mulatta	KIFAP3	VGNC	VGNC:73842
Bos taurus	KIFAP3	VGNC	VGNC:30610

Name
Email *

	Sorry, but the email address you supplied was invalid.