MSRB2 - methionine sulfoxide reductase B2 Gene

Homo sapiens

Also known as CBS1; MSRB; PILB; CBS-1; CGI-131

Gene ID: 22921 | Gene type: protein coding

About MSRB2

Cytogenetic location: 10p12.2 Genomic coordinates (GRCh38): 10:23,095,579-23,122,013 (from NCBI)

This gene has 3 transcripts (splice variants), 101 orthologues and 3 paralogues. Ubiquitous expression in heart (RPKM 17.2), liver (RPKM 8.9) and 24 other tissues.

Summary

Predicted to enable actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization and protein repair. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MSRB2 Products(1)

mRNA	Protein	Name
NM_012228.4	NP_036360.3	methionine-R-sulfoxide reductase B2, mitochondrial precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27499296	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSRB2 Protein Structure

SelR

0
100
182 a.a.

Protein Preferred Names

Protein Names

methionine-R-sulfoxide reductase B2, mitochondrial

pilin-like transcription factor

MSRB2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MSRB2	Q9Y3D2	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	MSRB2	Q9Y3D2	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	MSRB2	Q9Y3D2	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	MSRB2	Q9Y3D2	APOE	Homo sapiens	P02649	Validated Y2H	32814053
Intra	MSRB2	Q9Y3D2	APOE	Homo sapiens	P02649	Y2H Array	32814053
Intra	MSRB2	Q9Y3D2	APOE	Homo sapiens	P02649	Y2H Pooling	32814053
Intra	MSRB2	Q9Y3D2	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	MSRB2	Q9Y3D2	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	MSRB2	Q9Y3D2	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	MSRB2	Q9Y3D2	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	MSRB2	Q9Y3D2	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	MSRB2	Q9Y3D2	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	MSRB2	Q9Y3D2	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	MSRB2	Q9Y3D2	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	MSRB2	Q9Y3D2	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	MSRB2	Q9Y3D2	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	MSRB2	Q9Y3D2	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	MSRB2	Q9Y3D2	NDRG1	Homo sapiens	Q92597	Validated Y2H	32814053
Intra	MSRB2	Q9Y3D2	NDRG1	Homo sapiens	Q92597	Y2H Array	32814053
Intra	MSRB2	Q9Y3D2	NDRG1	Homo sapiens	Q92597	Y2H Pooling	32814053
Intra	MSRB2	Q9Y3D2	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	MSRB2	Q9Y3D2	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	MSRB2	Q9Y3D2	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypomagnesemia 6, Renal

Renal Hypomagnesemia 6	HOMG6
Renal Hypomagnesemia-6	Hypomagnesemia 6
Hypomagnesemia, Type 6, Renal

Neu-Laxova Syndrome 2

NLS2

Myotonia Congenita

Congenital Myotonia, Autosomal Dominant Form	Congenital Myotonia
Thomsen And Becker Disease	Thomsen Disease
Thomsen'S Disease	Generalized Myotonia Of Thomsen
Congenital Myotonic Muscular Dystrophy	Myotonia Congenita Nos

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08727	MSRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MSRB2	VGNC	VGNC:74786
Bos taurus	MSRB2	VGNC	VGNC:31706
Rattus norvegicus	MSRB2	RGD	RGD:1306026
Mus musculus	MSRB2	MGD	MGI:1923717
Canis familiaris	MSRB2	VGNC	VGNC:43450

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