2. Gene
  3. TPX2 - TPX2 microtubule nucleation factor Gene

TPX2 - TPX2 microtubule nucleation factor Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DIL2; p100; DIL-2; HCTP4; FLS353; HCA519; REPP86; C20orf1; C20orf2; GD:C20orf1

Gene ID: 22974 | Gene type: protein coding

About TPX2

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:31,739,290-31,801,800 (from NCBI)

This gene has 2 transcripts (splice variants) and 209 orthologues. Broad expression in testis (RPKM 19.8), bone marrow (RPKM 18.0) and 16 other tissues.

Summary

Enables importin-alpha family protein binding activity and protein kinase binding activity. Involved in activation of protein kinase activity; microtubule Cytoskeleton organization; and negative regulation of microtubule depolymerization. Located in intercellular bridge; mitotic spindle; and nucleoplasm. Colocalizes with spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

TPX2 Products(1)

mRNA Protein Name
NM_012112.5 NP_036244.2 targeting protein for Xklp2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables importin-alpha family protein binding IDA
IDA: Inferred from direct assay
26165940 GOA
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
37728657 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14580337 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
14580337 GOA
Biological Process GO Annotation Evidence Reference Source
involved in activation of protein kinase activity IDA
IDA: Inferred from direct assay
14580337 GOA
involved in microtubule nucleation IDA
IDA: Inferred from direct assay
26414402 GOA
involved in mitotic spindle assembly IDA
IDA: Inferred from direct assay
26165940 GOA
involved in negative regulation of microtubule depolymerization IDA
IDA: Inferred from direct assay
26414402 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in spindle IDA
IDA: Inferred from direct assay
37728657 GOA
colocalizes with spindle pole IDA
IDA: Inferred from direct assay
14718566 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPX2 Protein Structure

Aurora-A_bind

Aurora-A_bind: Aurora-A binding (1 - 68)

TPX2_importin

TPX2_importin: Cell cycle regulated microtubule associated protein (362 - 542)

TPX2

TPX2: Targeting protein for Xklp2 (TPX2) (662 - 718)

  • 0
  • 200
  • 400
  • 600
  • 747 a.a.
Protein Preferred Names Protein Names

targeting protein for Xklp2

TPX2, microtubule-associated protein homolog

TPX2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TPX2 Q9ULW0 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
TPX2 Q9ULW0 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
TPX2 Q9ULW0 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
TPX2 Q9ULW0 HMMR Homo sapiens O75330
Anti Bait CoIP
22110403
Intra
TPX2 Q9ULW0 GRB2 Homo sapiens P62993
Peptide Array
17474147
Intra
TPX2 Q9ULW0 AURKA Homo sapiens O14965
X-Ray Diffraction
14580337
Intra
TPX2 Q9ULW0 AURKA Homo sapiens O14965
Anti Bait CoIP
22110403
Intra
TPX2 Q9ULW0 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
TPX2 Q9ULW0 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
TPX2 Q9ULW0 CDH1 Homo sapiens P12830
Y2H Pooling
32814053
Intra
TPX2 Q9ULW0 CDH1 Homo sapiens P12830
Validated Y2H
32814053
Intra
TPX2 Q9ULW0 CDH1 Homo sapiens P12830
Y2H Array
32814053
Intra
TPX2 Q9ULW0 PIK3R1 Homo sapiens P27986
Peptide Array
17474147
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Capillary Leak Syndrome

Systemic Capillary Leak Syndrome

Clarkson Disease

Capillary Leak Syndrome With Monoclonal Gammopathy

Scls

Periodic Systemic Capillary Leak Syndrome

Capillary Hyperpermeability Syndrome

Idiopathic Capillary Leak Syndrome
Capillary Disease

Disease Of Capillaries
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-125956 Aurkin A Inhibitor ≥98.0% Unkown
HY-168022 CAM2602 99.85% Unkown
HY-158038 AurkA allosteric-IN-1 Inhibitor / Unkown
HY-RS14959 TPX2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TPX2 MGD MGI:1919369
Rattus norvegicus TPX2 RGD RGD:1311894
Macaca mulatta TPX2 VGNC VGNC:78697
Canis familiaris TPX2 VGNC VGNC:47757
Bos taurus TPX2 VGNC VGNC:36266
Felis catus TPX2 VGNC VGNC:66489
Others TPX2 NCBI