USP33 - ubiquitin specific peptidase 33 Gene

Homo sapiens

Also known as VDU1

Gene ID: 23032 | Gene type: protein coding

About USP33

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:77,695,987-77,759,852 (from NCBI)

This gene has 18 transcripts (splice variants), 211 orthologues and 71 paralogues. Ubiquitous expression in fat (RPKM 19.0), brain (RPKM 15.9) and 25 other tissues.

Summary

This gene encodes a deubiquinating Enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 Adrenergic Receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

USP33 Products(13)

mRNA	Protein	Name
NM_001377430.1	NP_001364359.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 4
NM_001377431.1	NP_001364360.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 5
NM_001377432.1	NP_001364361.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 6
NM_001377433.1	NP_001364362.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 7
NM_001377434.1	NP_001364363.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 8
NM_001377435.1	NP_001364364.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 9
NM_001377436.1	NP_001364365.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 10
NM_001377437.1	NP_001364366.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 11
NM_001377438.1	NP_001364367.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 12
NM_001377439.1	NP_001364368.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 12
NM_015017.5	NP_055832.3	ubiquitin carboxyl-terminal hydrolase 33 isoform 1
NM_201624.3	NP_963918.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 2
NM_201626.3	NP_963920.1	ubiquitin carboxyl-terminal hydrolase 33 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor binding	IPI IPI: Inferred from physical interaction	19424180	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	23486064	GOA
enables cysteine-type deubiquitinase activity	IMP IMP: Inferred from mutant phenotype	24056301	GOA
enables cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	19363159	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11739384	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	24056301	GOA
NOT enables ubiquitin binding	IDA IDA: Inferred from direct assay	17766394	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	17766394	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to starvation	IDA IDA: Inferred from direct assay	24056301	GOA
involved in centrosome duplication	IMP IMP: Inferred from mutant phenotype	23486064	GOA
involved in negative regulation of protein binding	IMP IMP: Inferred from mutant phenotype	24056301	GOA
involved in positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	24056301	GOA
involved in protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	19363159	GOA
involved in protein K63-linked deubiquitination	IDA IDA: Inferred from direct assay	19363159	GOA
involved in protein deubiquitination	IDA IDA: Inferred from direct assay	11739384	GOA
involved in protein deubiquitination	IMP IMP: Inferred from mutant phenotype	24056301	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	23486064	GOA
involved in regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19363159	GOA
involved in regulation of autophagy	IMP IMP: Inferred from mutant phenotype	24056301	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	21801292	GOA
located in centrosome	IDA IDA: Inferred from direct assay	23486064	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	24056301	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP33 Protein Structure

zf-UBP

UCH

DUSP

0
200
400
600
800
942 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 33

VHL-interacting deubiquitinating enzyme 1

USP33 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP33	Q8TEY7	EGFR	Homo sapiens	P00533	Ub Reconstruction	27956147
Intra	USP33	Q8TEY7	EGFR	Homo sapiens	P00533	Anti Tag CoIP	27956147

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15544	USP33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	USP33	VGNC	VGNC:66879
Rattus norvegicus	USP33	RGD	RGD:1307848
Bos taurus	USP33	VGNC	VGNC:36723
Canis familiaris	USP33	VGNC	VGNC:48189
Macaca mulatta	USP33	VGNC	VGNC:79217
Mus musculus	USP33	MGD	MGI:2159711

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