2. Gene
  3. USP33 - ubiquitin specific peptidase 33 Gene

USP33 - ubiquitin specific peptidase 33 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as VDU1

Gene ID: 23032 | Gene type: protein coding

About USP33

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:77,695,987-77,759,852 (from NCBI)

This gene has 18 transcripts (splice variants), 211 orthologues and 71 paralogues. Ubiquitous expression in fat (RPKM 19.0), brain (RPKM 15.9) and 25 other tissues.

Summary

This gene encodes a deubiquinating Enzyme important in a variety of processes, including Slit-dependent cell migration and beta-2 Adrenergic Receptor signaling. The protein is negatively regulated through ubiquitination by von Hippel-Lindau tumor protein (VHL). Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

USP33 Products(13)

mRNA Protein Name
NM_001377430.1 NP_001364359.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 4
NM_001377431.1 NP_001364360.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 5
NM_001377432.1 NP_001364361.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 6
NM_001377433.1 NP_001364362.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 7
NM_001377434.1 NP_001364363.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 8
NM_001377435.1 NP_001364364.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 9
NM_001377436.1 NP_001364365.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 10
NM_001377437.1 NP_001364366.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 11
NM_001377438.1 NP_001364367.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 12
NM_001377439.1 NP_001364368.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 12
NM_015017.5 NP_055832.3 ubiquitin carboxyl-terminal hydrolase 33 isoform 1
NM_201624.3 NP_963918.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 2
NM_201626.3 NP_963920.1 ubiquitin carboxyl-terminal hydrolase 33 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled receptor binding IPI
IPI: Inferred from physical interaction
19424180 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
23486064 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
24056301 GOA
enables cysteine-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
19363159 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11739384 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
24056301 GOA
NOT enables ubiquitin binding IDA
IDA: Inferred from direct assay
17766394 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
17766394 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to starvation IDA
IDA: Inferred from direct assay
24056301 GOA
involved in centrosome duplication IMP
IMP: Inferred from mutant phenotype
23486064 GOA
involved in negative regulation of protein binding IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in positive regulation of protein binding IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in protein K48-linked deubiquitination IDA
IDA: Inferred from direct assay
19363159 GOA
involved in protein K63-linked deubiquitination IDA
IDA: Inferred from direct assay
19363159 GOA
involved in protein deubiquitination IDA
IDA: Inferred from direct assay
11739384 GOA
involved in protein deubiquitination IMP
IMP: Inferred from mutant phenotype
24056301 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
23486064 GOA
involved in regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19363159 GOA
involved in regulation of autophagy IMP
IMP: Inferred from mutant phenotype
24056301 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
21801292 GOA
located in centrosome IDA
IDA: Inferred from direct assay
23486064 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
24056301 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP33 Protein Structure

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (61 - 122)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (184 - 712)

DUSP

DUSP: DUSP domain (847 - 916)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 942 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 33

VHL-interacting deubiquitinating enzyme 1

Related Diseases

Diseases Alias
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15544 USP33 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus USP33 VGNC VGNC:66879
Rattus norvegicus USP33 RGD RGD:1307848
Bos taurus USP33 VGNC VGNC:36723
Canis familiaris USP33 VGNC VGNC:48189
Macaca mulatta USP33 VGNC VGNC:79217
Mus musculus USP33 MGD MGI:2159711