2. Gene
  3. PHLPP2 - PH domain and leucine rich repeat protein phosphatase 2 Gene

PHLPP2 - PH domain and leucine rich repeat protein phosphatase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PPM3B; PHLPPL

Gene ID: 23035 | Gene type: protein coding

About PHLPP2

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,644,924-71,724,701 (from NCBI)

This gene has 7 transcripts (splice variants), 186 orthologues and 31 paralogues. Broad expression in small intestine (RPKM 11.5), colon (RPKM 5.9) and 22 other tissues.

Summary

Predicted to enable protein serine/threonine Phosphatase activity. Predicted to be involved in signal transduction. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PHLPP2 Products(2)

mRNA Protein Name
NM_001289003.1 NP_001275932.1 PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 2
NM_015020.3 NP_055835.2 PH domain leucine-rich repeat-containing protein phosphatase 2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18162466 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHLPP2 Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (324 - 344)

LRR_1

LRR_1: Leucine Rich Repeat (346 - 367)

LRR_8

LRR_8: Leucine rich repeat (572 - 632)

LRR_8

LRR_8: Leucine rich repeat (645 - 703)

PP2C

PP2C: Protein phosphatase 2C (849 - 1026)

  • 0
  • 300
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  • 1200
  • 1323 a.a.
Protein Preferred Names Protein Names

PH domain leucine-rich repeat-containing protein phosphatase 2

protein phosphatase, Mg2+/Mn2+ dependent 3B

Related Diseases

Diseases Alias
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Optic Atrophy 8

OPA8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19820A NSC45586 sodium ≥98.0% Unkown
HY-19820 NSC45586 / Unkown
HY-RS10448 PHLPP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PHLPP2 VGNC VGNC:44505
Bos taurus PHLPP2 VGNC VGNC:32841
Felis catus PHLPP2 VGNC VGNC:97553
Macaca mulatta PHLPP2 VGNC VGNC:81494
Rattus norvegicus PHLPP2 RGD RGD:1562857
Mus musculus PHLPP2 MGD MGI:2444928
Others PHLPP2 NCBI