ERP44 - endoplasmic reticulum protein 44 Gene

Homo sapiens

Also known as PDIA10; TXNDC4

Gene ID: 23071 | Gene type: protein coding

About ERP44

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:99,979,185-100,099,000 (from NCBI)

This gene has 15 transcripts (splice variants), 208 orthologues and 13 paralogues. Ubiquitous expression in thyroid (RPKM 19.6), placenta (RPKM 16.9) and 25 other tissues.

Summary

This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-retention sequence. This protein functions as a pH-regulated chaperone of the secretory pathway and likely plays a role in protein quality control at the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec 2016]

ERP44 Products(1)

mRNA	Protein	Name
NM_015051.3	NP_055866.1	endoplasmic reticulum resident protein 44 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17805346	GOA
enables protein disulfide isomerase activity	IDA IDA: Inferred from direct assay	11847130	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycoprotein metabolic process	IDA IDA: Inferred from direct assay	11847130	GOA
involved in protein folding	IDA IDA: Inferred from direct assay	11847130	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	11847130	GOA
involved in response to unfolded protein	IDA IDA: Inferred from direct assay	11847130	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	19995400	GOA
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	11847130	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	11847130	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERP44 Protein Structure

Thioredoxin

Thioredoxin_6

0
100
200
300
406 a.a.

Protein Preferred Names

Protein Names

endoplasmic reticulum resident protein 44

ER protein 44

Recombinant ERP44 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70901	TXNDC4 Protein, Human (HEK293, His)	Q9BS26 (E30-D402)	≥95%

Related Diseases

Diseases

Alias

Multiple Sulfatase Deficiency

Mucosulfatidosis	MSD
Sulfatidosis, Juvenile, Austin Type	Multiple Sulfatase Deficiency Disease
Juvenile Sulfatidosis, Austin Type	Juvenile Sulfatidosis
Sulfatidosis Juvenile, Austin Type	Austin Syndrome
Sulfatidosis Juvenile Austin Type	Sulfatase Deficiency, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04515	ERP44 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ERP44	MGD	MGI:1923549
Macaca mulatta	ERP44	VGNC	VGNC:72295
Bos taurus	ERP44	VGNC	VGNC:28597
Felis catus	ERP44	VGNC	VGNC:61957
Canis familiaris	ERP44	VGNC	VGNC:51716
Rattus norvegicus	ERP44	RGD	RGD:1309176

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