ARHGAP26 - Rho GTPase activating protein 26 Gene

Homo sapiens

Also known as GRAF; GRAF1; OPHN1L; OPHN1L1

Gene ID: 23092 | Gene type: protein coding

About ARHGAP26

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:142,770,377-143,229,011 (from NCBI)

This gene has 23 transcripts (splice variants), 210 orthologues, 3 paralogues and is associated with 76 phenotypes. Ubiquitous expression in brain (RPKM 7.0), gall bladder (RPKM 4.5) and 24 other tissues.

Summary

Interaction of a cell with the extracellular matrix triggers Integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

ARHGAP26 Products(3)

mRNA	Protein	Name
NM_001135608.3	NP_001129080.1	rho GTPase-activating protein 26 isoform b
NM_001349547.2	NP_001336476.1	rho GTPase-activating protein 26 isoform c
NM_015071.6	NP_055886.1	rho GTPase-activating protein 26 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phospholipid binding	IDA IDA: Inferred from direct assay	18954304	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11432776	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	38081847	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitophagy	IDA IDA: Inferred from direct assay	38081847	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	32344433	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	32344433	GOA
is active in mitochondrion	IDA IDA: Inferred from direct assay	38081847	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP26 Protein Structure

IMD

RhoGAP

SH3_9

0
200
400
600
814 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 26

GTPase regulator associated with focal adhesion kinase pp125(FAK)

ARHGAP26 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARHGAP26	Q9UNA1	PKN3	Homo sapiens	Q6P5Z2	Pull Down	11432776
Intra	ARHGAP26	Q9UNA1	CDC42EP2	Homo sapiens	O14613	Validated Y2H	25416956
Intra	ARHGAP26	Q9UNA1	CDC42EP2	Homo sapiens	O14613	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic	JMML
Leukemia, Juvenile Myelomonocytic, Somatic	Juvenile Chronic Myelomonocytic Leukemia
Juvenile Chronic Myelogenous Leukemia	Leukemia, Myelomonocytic, Juvenile
Juvenile Myelomonocytic Leukaemia Without Mention Of Remission

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Alpha-Thalassemia

Alpha Thalassemia	Alpha Thalassaemia
Alpha Plus Thalassemia	Thalassemia, Alpha-
Thalassemias, Alpha-	A-Thalassemia
Α-Thalassemia	A-THAL
Thalassemia	Alpha Thalassaemia Syndrome

Diffuse Gastric Cancer

Hereditary Diffuse Gastric Adenocarcinoma	Hereditary Diffuse Gastric Cancer
Signet Cell Adenocarcinoma	Signet Ring Cell Carcinoma
Signet Ring Cell Gastric Carcinoma	Signet Ring Gastric Carcinoma
Fdgc	Familial Diffuse Cancer Of Stomach
Familial Diffuse Gastric Cancer	Gastric Cancer, Familial Diffuse
Gastric Cancer, Hereditary Diffuse	Hdgc
Hereditary Diffuse Cancer Of Stomach	Diffuse Gastric Cancer Syndrome
Cancer, Gastric, Diffuse	Carcinoma, Signet Ring Cell
Gastric Signet Ring Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00926	ARHGAP26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ARHGAP26	RGD	RGD:1310923
Canis familiaris	ARHGAP26	VGNC	VGNC:38054
Macaca mulatta	ARHGAP26	VGNC	VGNC:69846
Mus musculus	ARHGAP26	MGD	MGI:1918552
Bos taurus	ARHGAP26	VGNC	VGNC:26084
Felis catus	ARHGAP26	VGNC	VGNC:59883

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